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Broccoli and Watercress Sprouts Fight Cancer

In Anticancer foods, foods for colon cancer, foods for breast cancer, Cancer, Uncategorized on February 27, 2017 at 9:43 am

It is well known that cruciferous vegetables such as broccoli and watercress contain powerful anticancer compounds. But did you know that eating their respective sprouts can supercharge the health benefits? In sprout form these little three to four day old plants contain almost 100 times the level of cancer-fighting sulforaphane than the mature plants. The phytonutrients in these sprouts upregulate antioxidant enzymes and detoxification processes which clear toxic compounds from the body. And, that is just the beginning—read on to find out how sprouts knock the socks off cancer.

 What’s in a Sprout

Isothiocyanates (ITCs), such as sulforaphane, are sulfur-containing compounds found in cruciferous vegetables. They support matrix metalloproteinase-9 (MMP-9) activity which reduces the breakdown of connective tissue within a cell that impede the expansion of existing tumors. Matrix MMP-9 plays important roles in tumor invasion and angiogenesis. Secretion of MMP-9 has been reported in various cancer types including lung, colon, and breast cancer.

ITCs also kill off cancer cells, including cancer stem cells, which is essential for combating cancer metastases. Isothiocyanates restrain certain pro-inflammatory compounds that are associated with chronic inflammation and cancer.

The ITC sulforaphane helps support the anti-inflammatory Nrf2 pathway which protects cells against oxidative and free radical activity. It supports the detoxification process by inducing Phase 2 detoxification enzymes, inhibiting the activation of pro-carcinogens, and  by boosting cellular glutathione levels.  Sulforaphane promotes cancer cell death and inhibits cancer cell proliferation. It also supports the immune system and in particular, increases Natural Killer Cell activity.

Sulforaphane also inhibits Helicobacter pylori, the bacterium that increases one’s risk of stomach and colorectal cancer.  It is also anti-viral and has been found effective against the Epstein Barr Virus.

Quercetin, another potent antioxidant highly concentrated in sprouts, is a strong anti-inflammatory and prevents tumor cell growth.  It also aids in the removal of excess estrogen from the body — it stimulates liver function to detoxify estrogen and other carcinogenic agents.

Lutein is another powerful antioxidant that neutralizes cancer-causing free radicals (it is also essential for many things, including eye health, protecting against macular degeneration, and for maintaining strong eye tissue). Lutein (and zeaxanthin) may be beneficial to cardio health by preventing hardening of the arteries.

Glutathione has been labeled the ‘mother of all antioxidants” due to its incredible ability to disarm free radicals, detoxify the body, and boost the immune system.

Broccoli Sprouts

broccoli-sproutsBroccoli sprouts are extremely high in cancer fighting activity, particularly against lung, colon, and breast cancers. Compounds in broccoli speed up the removal of estrogen from the body, helping to suppress breast cancer. They also target cancer stem cells, the cells responsible for metastasis.

Broccoli sprouts contain a high amount of the cancer-busting and immune boosting substance sulforaphane. They are also abundant in quercetin, glutathione, beta carotene, indoles, vitamin C, lutein, glucarate, and the metabolic substance DIM, which is a natural aromatase inhibitor.

Broccoli sprouts are rich in cholesterol reducing fiber and have anti-viral and anti-ulcer activity. They are also a super source of chromium that helps regulate insulin and blood sugar.

 

Watercress Sproutswatercress-sprouts

Sometimes called peppergrass, watercress is delicious and pungent. It is also one of the most nutrient-dense foods known. It is rich in beta-carotene and other carotenoids, including lutein. Watercress also offers significant quercetin, EGCG (Epigallocatechin Gallate), flavanols such a kaempferol, lycopene, idole-3 carbinol (13C), sulforaphane, as well as DIM. It is a good source of riboflavin, vitamin C, A and K, calcium, magnesium, vitamin E, and contains trace amounts of omega 3’s. Watercress is one of the best food sources of iodine for vegans.

Watercress also contains a high amount of PEITC (phenylethylisothiocyanate) which has been shown to protect DNA from damage. PEITC reduces the growth of breast cancer cells, triggers apoptosis (cancer cell death), and decreases angiogenesis. It inhibits the growth of HER2 expression as well as cancer metastasis.

PEITC (also found in some other cruciferous vegetables, including broccoli) deactivates mutant p53 in tumor cells but leaves normal p53 alone. P53 regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way. A mutation in p53 is a permanent change in the nucleotide sequence of DNA. Loss of p53 function can be deleterious, and about 50% of all human cancers have a mutated p53 gene.

Watercress has antioxidant, antigenotoxic (the process by which chemical agents damage genetic information within a cell causing mutations), and anti-inflammatory properties.

Studies show that a regular intake of watercress has been associated with protection against breast, colon, and other cancers.

Watercress and broccoli affect all stages of cancer: initiation, proliferation, and metastasis. So, what’s not to love about these sprouts? Plus, it is a lot easier to consume a handful of sprouts than it is to down a pound and a half of broccoli or an enormous plate of watercress– which, for example,  is the amount it would take to get an equivalent amount of sulforaphane.

Add sprouts to your smoothies; use on sandwiches, on top of pizza, in salads, and as a garnish for soups. I make wonderful gluten-free pizza crusts using cauliflower or garbanzo bean flour, and pile the pizza high with arugula and sprouts just before serving.  Yum!

Just a reminder that while  eating cruciferous vegetables is a important for optimal health, it is necessary to have sufficient iodine in the diet when consuming high quantities  (including DIM).

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Thanks!

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

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Organic Skin Care: The Fix Your Skin’s 2017 Expert Roundup

In organic skin care, Uncategorized on February 24, 2017 at 4:39 pm

I was recently asked by the online skin care and wellness website Fix Your Skin to give my recommendations for tips for organic skin care. They asked over 200 experts for their top 3 tips, and I was more than happy to contribute. Most women don’t realize that what we put on our body is just as important as what we put in it. Chemicals in personal care products come with a plethora of carcinogenic chemicals.

fix-your-skin-expert-roundup-1058x574

Overall, we said that hydration, organic skin care, and diet were most important. Below are my tips, but don’t forget to check out all the other expert tips.

1. Keep Hydrated. Drink plenty of spring or filtered water every day. This will plump to help smooth wrinkles and avoid dark circles under the eyes. Proper hydration will also help to flush out toxins from your body that are not only bad for the body in general, but will accelerate the aging process. Eating plenty of organic fruits and vegetables will help to keep you hydrated and will give your skin the vitamins and minerals it needs for healthy, vibrant skin.
2. Avoid too much direct sun exposure (some is good for mind, body, and soul). While the sun’s rays will allow your body to make anticancer, pro-health vitamin D, too much will age the skin.
3. Use organic, non-toxic beauty products. Chemical based products contain harmful ingredients that increase your risk of cancer and harm your skin. Gone are the days of smelly products that don’t work. Some of my favorites are Derma-e, Naturopathica, and Mineral Fusion.

But don’t forget, good sleep is essential too!

View the entire article Fix Your Skin 2017 Expert Roundup

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

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Bone Health Myth for Breast Cancer Patients

In Bone Health Cancer Treatments on February 11, 2017 at 10:09 am

Are you worried about the effect breast cancer treatment can have on your bones? Has your doctor recommended an aromatase inhibitor to manage your breast cancer? Or have you been diagnosed with osteoporosis or have been told you are at risk of bone loss?

Unfortunately, much of what your doctor may have told you about bone loss and bone-regrowth may not exactly be the truth—and well, you might have been led down the infamous ‘primrose path’ about aromatase inhibitors.  However, you need to know that there are safe, effective ways to build strong healthy bones—without harmful drugs.

The Problem with Calcium Supplements

Common calcium supplements are not particularly beneficial. First of all, if calcium works so well for building bones, why do millions still suffer from osteoporosis and osteopenia? Clearly calcium is not the answer–at least not alone in the standard supplement form.  Plus, calcium supplements are not risk-free.

Numerous studies have found calcium supplements to increase risk of heart attack and stroke.  Researchers at Johns Hopkins found that calcium supplements accelerate vascular calcification and increase mortality in patients with renal failure.  They determined that calcium builds up in the arteries, inhibits blood flow, and increases the risk of heart attack.

A 2013 study done by the NIH (National Institutes of Health) found there is an increased risk of heart attack, stroke or other cardiovascular diseases from taking calcium supplements.  Other studies have found the same results.

Plus, you need to be careful with most calcium supplements as many have a high lead content. Believe, me, it is far better to get your calcium from food, or at the very least, plant-based supplements
Dietary calcium from grass-fed cheeses, leafy greens, and other plant sources are helpful because they are taken in small amounts that are absorbed throughout the day, whereas supplements tend to be taken all at once, causing blood calcium levels to spike above normal, which might not be a good thing.

The Problem with Aromatase Inhibitors and Bone Loss

Hormonal treatment for breast and prostate cancer can lead to bone loss and increase the risk for osteoporosis and fractures. Breast cancer patients treated with aromatase inhibitors are more likely to have bone loss and fractures. Aromatase inhibitors (AIs) are associated with significant risk of osteoporotic fractures and bone mineral loss. Similarly, men who receive androgen deprivation therapy to treat their prostate cancer face an increased risk of bone disorders.

Estrogen plays a major role in the growth and maturation of bone, which involves the remodeling of bone.  Cells known as osteoclasts dissolve bone tissue, and then osteoblasts fill in the holes. This process is disturbed when there are low serum estrogen levels. A deficiency of estrogen causes bone loss and cancellous bone, otherwise known as spongy bone.

Bisphosphonates such as Fosamax, and others, aim to slow the rate of bone loss.  Yet, they come with serious side effects (damage to the lining of the esophagus and stomach; damage to the jaw bone, which can mean jaw pain, loose teeth; nausea, indigestion, heartburn and host of other issues) and do not appear to be very effective. Studies have found that bisphosphonates actually cause your bones to become brittle and vulnerable to fractures.

A 2015 meta-analysis of 33 studies was published in the BMJ (British Medical Journal). The analysis concluded that bisphosphonates actually disrupt normal bone remodeling and do nothing to prevent fractures. Instead, they make bones more susceptible to fracture. There is a better way.

Natural Solutionsiphone-transfer-photos-432

  • Sunshine or Vitamin D helps the body absorb calcium. The amount needed will vary per individual, so it is important to have your vitamin D levels monitored by your doctor.
  • Vitamin K2— it is critical to have sufficient Vitamin K2 in order to ensure that calcium is bound and held in bones and at the same time is removed from our arteries, joints or other tissues where it doesn’t belong. K2 also provides defense against fluoride calcification in soft tissue organs such as the arteries and brain. Vitamin K2 also inhibits cancer cell lines, such as colon, breast, leukemia, brain, and many more.
  • Strontium — Strontium is a common metallic element that the body can absorb and use as if it were calcium. It is a naturally occurring mineral in the same mineral family as calcium and magnesium that has been shown to promote bone growth. Doctors have known for years that strontium builds bone.  Numerous studies show that it works better than calcium. However, while strontium can be found in food sources, there’s not enough in food to have a significant effect if you already have osteoporosis or osteopenia. Therefore, you might want to take strontium in supplement form. If you don’t currently have osteoporosis, then eating plenty of food high in strontium may be enough to protect you. Foods high in strontium include spices, seafood, whole grains, root and leafy vegetables, and legumes.  (If supplementing, consider 200-500 mg daily).  Don’t take your strontium with calcium as they compete with each other for absorption.
  • Orthosilicic acid: Research shows that orthosilicic acid promotes the formation of osteoblasts, the cells that build bone. The more osteoblasts you make, the denser your bones will be.  Scientists have also discovered that orthosilicic acid may help promote bone formation by stimulating the production of collagen –a protein found in connective tissue, including bone– which helps to bind muscle and bone tissue together and increases bone mass. Orthosilicic acid is often called soluble silica, and is found in foods like oats, barley, seawater, and some drinking water.  Beer has a high concentration of silicon (silica).  Dark beer in particular, with its high hop content, contains significant silicon. While yes, drinking beer will support bone mineralization and the creation of collagen, bone broth or taking hops might be just a bit better for you. (See bone broth below). 
  • Bone broth is extremely high in mineral such as calcium, magnesium, potassium, and phosphorus. Plus, the minerals in bone broth support the immune system and contain many healing compounds such as proline, glycine, glutamine, and collagen. Collagen plays an important role in the building of strong, flexible bones.
  • Magnesium is necessary to convert vitamin D into its active form so that it can turn on calcium absorption. That can often mean that we might not need extraordinarily high doses of vitamin D, but rather a combination of vitamin D along with magnesium and other nutrients to make the vitamin D work efficiently. Like vitamin K2, magnesium helps to preserve bone structure by drawing calcium out of the blood and soft tissues back into the bones.
  • Green leafy vegetables provide calcium, strontium, and other essential minerals necessary for bone health.
  • Lysine builds collagen, which holds your bones together—sort of like glue. It also helps your body absorb calcium and decreases the amount you excrete in urine.  (500-2000 daily)
  • Manganese promotes bone growth; leafy vegetables and pumpkin seeds and teas are great sources. You may also find that you get manganese in your multi-vitamin.
  • Copper –while copper slows bone loss and is essential in small amounts, it also supports cancer. So, while you need some, don’t take too much (supplements should not exceed 2mg), including through food choices.
  • Boron increases bone strength, supports bone mass, and slows bone loss. Likely you will get boron in your multi.
  • Zinc also builds bone and helps them from becoming brittle (30-50 mg daily)

So, with all these safe and healthful natural substances, why are doctors still prescribing calcium and harmful drugs that clearly are not working? At least now you are empowered to improve your bone health without harmful drugs.

Found this article helpful?  Please let me know.

 

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

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Epstein Barr Virus and the Development of Cancer

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Anticancer foods, foods for colon cancer, foods for breast cancer, Breast Cancer, Uncategorized on January 24, 2017 at 4:02 pm

The Epstein-Barr Virus (EBV) is one of the most common viral infections in humans. It is also one of the most prolific–over 95% of adults carry this virus. While originally linked to lymphoma, subsequent research has linked EBV to stomach cancer, nasopharyngeal cancer, and many others, including breast cancer.

Once you are infected with EBV, it remains dormant in the body forever, often asymptomatic. For some, this will not be a problem.  For others, it can result in long-term consequences, including dramatically raising one’s risk of cancer as well as aggressive progression of the disease.

When reactivated, EBV can present with symptoms such as cold sores or flu-like symptoms. But again, often there are no symptoms—yet the virus is at work, leaving genetic scars on our cells. Molecules produced by EBV can send infected cells into overdrive, telling them to keep dividing.  Importantly, EBV does not initiate cancer on its own — there are other elements at play. It is a combination of genes and diet along with the EBV infection that create the perfect storm for cancer.

Herpetic viruses such as EBV are so often behind autoimmune disorders such as lupus, MS, and Hashimoto’s thyroiditis. Hence, many with autoimmune issues will also develop cancer.

The Immune System is Our First Line of Defense Against Infections

With EBV, it can also be a bit of the chicken and the egg theory.  Fighting the infection itself could exhaust the immune response, which might hinder detection and destruction of cancer cells, allowing them to replicate.  Or, it could be that an already weak immune system, combined with a poor diet, leaves the door open to infection and flare-ups of dormant Epstein Barr and the development and progression of cancer.

Researchers are working on ways to uncloak the virus to immune cells in hopes that this will rid the body of EBV, rather than leave dormant infection around to cause problems. Will that mean another controversial vaccine? Possibly.

Food Matters

However, there are many natural substances that can suppress viral reactivation. For more information on EBV and its link to cancer, please read the following article I wrote for The Truth About Cancer: Epstein Barr Virus Connection to Breast Cancer & Autoimmune Disorders. In it you will also learn about the triggers for reactivation as well as the dietary choices, supplements, and herbs that suppress the EBV and help your body defend itself against cancer.

Found this article helpful?  Please let me know.

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

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Other articles you might like:

Herpes Virus (CMV) Linked to Most Common Type of Childhood Cancer (ALL)

12 Things a Cancer Doctor Should Never Say

10 Questions to Ask BEOFRE Accepting Radiation Therapy for Cancer

12 Questions to Ask BEFORE Saying “Yes” to Chemotherapy Treatment

Girls, Puberty & Breast Cancer Risk: What Moms Need to Know Now

What Your Oncologist Isn’t Telling You About Chemotherapy and Radiation

Are You Magnesium Deficient? How to Know & What to Do About It

Tap Water? No Thanks Unless it is Filtered

In Alternative Cancer Therapies, Breast Cancer, Cancer on January 22, 2017 at 3:26 pm

One thing I say to all of my clients is NO TAP WATER (at least not unfiltered).  We really don’t know what is in our water. For most of us, we do know there is chlorine and a host of other chemicals. We can also be sure that some of us have traces of pharmaceutical drugs in our water.  Many of us also have fluoride in our water.

All of these toxic chemicals are in some way carcinogenic and must be avoided.  The best solution, in the perfect world, is to have a whole-house filter.  Always keep in mind that when you bathe, you inhale and absorb through the skin the chemicals in water.

But as the world is not perfect, at the very least, we should filter our drinking and cooking water.  

So, what are the options. Likely you have heard of Berkey systems.  This is a great option for those looking for reliable clean water.  The Big Berkey  system removes pathogenic bacteria, cysts, and parasites and reduces harmful chemicals such as herbicides, pesticides, and VOCs without removing beneficial minerals. Berkey offers ceramic and black filters, the later also filters out fluoride and arsenic. There are only two problems with the Berkey systems. One is that these are expensive. The other is that they can be a nuisance to clean.

41g1euwr4l-_sy300_Another option is the ZeroWater pitcher (which is what I use). The filters filter out over 99% of contaminants, including fluoride and lead, and the water tastes great.  I was really amazed.  The pitchers come with a TDS indicator (total dissolved solids) so you know when to change the filter.  I had fun with this gadget, and tested our tap, Poland Springs, and Mountain Valley Spring.  Well, of course you know that the tap failed. The Poland Springs passed, as well as the Mountain Valley. While not a fan of the plastic used for the Poland Springs bottles (Mountain Valley comes in glass), at least there did not appear to be nasty things in the water. Of course, I am not thrilled that the Zero pitcher is plastic, but to get around that you can immediately put the water in a glass jug.  One note—if you are considering the stainless-steel pitcher to avoid the plastic, don’t bother.  The inside is plastic, so unless you just prefer the look, again, not worth the extra money.

While Brita makes a good line of inexpensive water pitchers, their filters do not remove fluoride, lead, and other toxins. According to their site, it reduces chlorine taste and odor, copper, mercury, and cadmium.

Another option is water distillation (reverse osmosis), which removes, fluoride, chlorine, lead, pesticides, etc. The price varies, but ranges from $200 to well over $1000.

Don’t want to filter your water?  Consider Mountain Valley Spring Water.  The water is delicious. The only drawback is that you have to stack the boxes someplace. Plus, even though we recycle the bottles, it still seems wasteful. Still, they are portable and great bedside, especially if you are like me and tend to knock over water glasses at night. One potential issue is that the water has a high alkaline ph. While this sounds like a good idea, drinking too much high alkaline water can disrupt the body’s natural ph. We need stomach acid to digest our food, so try not to drink high alkaline water before a meal or even all day long. Hence I drink their water and use the Zero system as well.

 

mountain valley spring water

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

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What You Need to Know About Mutations in the p53 Cancer Tumor Suppressor Gene

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Anticancer foods, foods for colon cancer, foods for breast cancer, colon cancer, High Dose Vitamin C and Cancer, Radiation on January 3, 2017 at 2:34 pm

The word mutation just doesn’t sound like something good. By definition, a mutation is a permanent change in DNA. Mutations, for the most part, are harmless except when they lead to tumor formation. 

Likely you have heard about BRCA mutations. BRCA genes are tumor suppressor genes. BRCA mutations can increase one’s risk for cancers of the breast and ovaries. However, these mutations are only responsible for about 5-10% of all breast cancers and about 15% of ovarian cancers. But, the little-known p53 mutation affects far more people. About 50% of all cancers have a mutated p53 gene.

What is P53?
The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. (It is actually the TP53 gene that provides instructions for making the tumor protein p53 but for simplicity, I will say p53.) P53 regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.

P53 plays a critical role in determining whether damaged DNA will be repaired or a damaged cell will self-destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors.

Mutated P53
P53 mutations lead to a version of p53 that cannot regulate cell growth and division effectively. Specifically, the altered protein is unable to trigger apoptosis in cells with mutated or damaged DNA.

DNA can be damaged by agents such as toxic chemicals, radiation such as gamma rays, X-rays — even UV light can interact with compounds in the cell generating free radicals which cause chemical damage to DNA.

Since all cells in our body contain DNA, there are lots of places for mutations such as p53 to occur. When p53 does not operate properly, damaged DNA can replicate, producing mutations and DNA rearrangements that contribute to the development of a highly transformed, metastatic cell. Many cancer cells inactivate p53, allowing the cells to evade death and continue proliferating up to becoming a tumor.

Mutant p53 proteins not only lose their tumor suppressive activities but often escalate the development of cancerous tumors by providing them with growth and survival mechanisms. Interestingly, mutations in the p53 gene have been shown to occur at different phases of the cancer process, contributing to tumor initiation, promotion, aggressiveness, and metastasis.

P53 mutations contribute to risk of brain tumors and breast, prostate, colon and other cancers. Mutations in p53 gene usually correlate with poor outcome and early recurrence in cancer.

Enough of the bad news.

The Good News
What is really exciting is that this repair gene, p53, which protects cells from becoming cancerous, can be highly activated by many natural substances—substances that do not have the negative side effects of drug therapies. The ability to activate p53 within cells may halt cell proliferation, or even cause cancer cell death.

 

watercressFor example, cruciferous vegetables (especially watercress with its high content of PEITC) have been found to support p53. PEITC (phenethylisothyanate) decreases the levels of mutated p53 and helps to restore the normal activity of this protein. Vitamin C is another promoter of P53, which is one of the reasons intravenous Vitamin C (IVC) and high-dose oral C therapies are so effective against cancer.
The resveratrol in red grapes and red wine (organic please, and research shows dark, red wines are best) also activates the P53 gene. IP6 has been shown to alter the expression of p53. Zinc helps protect the p53 gene against cancer-forming mutations. Selenium can activate p53 in response to genetic damage, helping the cell to repair its DNA. Herbs such as sage, rosemary, ginger, curcumin, and ashwaganda support p53. Thymoquinone extracted from black seed triggers apoptotic cell death in colorectal and other cancers cells via the p53- dependent mechanism. Anthocyanins, abundant in red  onions, inhibit the damage that impaired p53 can cause on cells and tissue. Anthocyanins are also found in blackberries, blueberries, purple grapes, eggplant, and avocado.

P53 Supporters:
• Cruciferous vegetables, especially watercress
IP6
Resveratrol
• Herbs such as sage, rosemary, ginger, curcumin, and ashwaganda
• EFA’s from omega 3 fatty acids (please use caution with fish oil supplements as they can be toxic). For a plant based formula, you could take BodyBio Balance Oil.
• Licorice
• Mistletoe
Vitamin D
Selenium
• Vitamin C
Zinc
Black Seed
Clinoptilolite (a special form of Zeolite)
On the other hand, processed foods, refined flours, and sugars will impair P53. Smokey flavoring and smoked foods can also damage DNA. Chemicals such as benzene and perchloroethylene, two volatile organic compounds, negatively affect p53, possibly causing them to stimulate rather than suppress cell proliferation.

The late Integrative Oncologist Dr Mitchell Gaynor, MD was famous for his passion for explaining that we can change the way our genes behave by making good dietary choices. For more gene-changing foods and lifestyle habits read Dr. Gaynor’s book, The Gene Therapy Plan, Taking Control of Your Genetic Destiny with Diet and Lifestyle.

P53 and BRCA are not the only genetic mutations that increase cancer risk. For example, mutations in th e CHEK2 gene are associated with an increased risk of developing many types of cancer, including breast, colon, prostate, and other cancers — sometimes at young ages. If you have a history of hereditary cancer you might benefit from genetic testing for CHEK2 and others.

Testing
You can request to be tested for the p53 mutation. The test is called the p53 Gene Mutation Analysis, Cell Based, offered by labs such as Quest Diagnostics. If your insurance company does not accept Quest or another lab that offers this test, you can petition your carrier for a Network Gap Exception.
You may need to consult a genetic counselor if your oncologist does not routinely check for mutations as these tests are not part of your typical pathology report.

Found this article helpful?  Please let me know.

 

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

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http://www.ambrygen.com/tests/chek2-related-cancer
http://www.nbs.csudh.edu/chemistry/faculty/nsturm/CHEMXL153/DNAMutationRepair.htm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827900/
https://ghr.nlm.nih.gov/gene/TP53
https://www.ncbi.nlm.nih.gov/pubmed/14608114
http://www.ambrygen.com/tests/chek2-related-cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135636/