elynjacobs

Posts Tagged ‘Quercetin and cancer’

Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment

In Alternative Cancer Therapies, Anticancer foods, foods for colon cancer, foods for breast cancer, Epstein-Barr Virus, foods that target cancer stem cells, High Dose Vitamin C and Cancer, Uncategorized on July 11, 2018 at 8:01 am

The following is an excerpt of my recently published article, Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment. It was published in the journal Archives of General Internal Medicine (Arch Gen Intern Med 2018 Volume 2 Issue 3).

The current standard of care, surgery, chemotherapy, and radiation has not proved to be highly effective and comes with significant side effects and costs. Although conventional cancer therapy can target certain cancer cells and sometimes prevent relapse of the illness, complementary and alternative therapies are required due to disadvantages of the current therapies such as low effectiveness, adverse effects, or availability. Moreover, a number of studies have found adjunctive therapeutic approaches to improve outcomes for cancer patients. One potential complementary method with conventional cancer drugs involves the use of medicinal herbs and phytochemicals. The possible therapeutic benefits include, but are not limited to, anti-proliferative, apoptotic, anti-metastatic, and anti-angiogenic effects, of which have been demonstrated in in vitro experiments and some clinical trials.

Studies have revealed beneficial effects of medicinal herbs and phytochemicals against cancer by providing anti-inflammatory, anti-bacterial, antiviral, free radical scavengers in the form of cancer-fighting compounds. Phytomedicines have the ability to interact with signaling pathways that modulate cell growth, replication, and death of a wide variety of tumor cell types through diverse mechanisms. These phytocomplexes have the remarkable capability of affecting us on a cellular level – where diseases such as cancer originate. Many plant species are already being used to treat or prevent development of cancer outside of the traditional oncology environment, notably without harm to healthy cells.

During the last century, scientific knowledge about anticancer phytochemicals and herbs has remarkably progressed. Despite numerous reports of their effects on cancer, functional use for the prevention and treatment of cancer has been largely limited to self-care. Like most cancer drugs, the main mechanisms of action of plants include inducing apoptosis and inhibiting proliferation, growth, and migration. But unlike conventional cancer drug therapies, phytotherapies are cytotoxic to cancer cells and relatively non-toxic to normal cells. Moreover, use of phytomedicines may be an option for the prevention and treatment of cancer both with and without conventional drugs. In the event that conventional cancer drugs are not accepted due to their side effects or low effectiveness, phytomedicines offer an effective and viable alternative as they are considerably safe and relatively affordable. It is worth recommending application of phytomedicines as alternative cancer therapies for patients who do not benefit or face side effects from conventional drugs or alongside conventional treatments to improve efficacy.

There are two sections in this review, phytochemicals against cancer and medical herbs against cancer. As it was impossible for me to address hundreds of different phytochemicals and medicinal herbs in this one paper, I only focused on a few examples in each category. To read the article in full, please read: Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment.

You may also enjoy my article published in the Journal of Cancer Biology and TreatmentEtiology of Chronic Disease: A Discussion on Epstein-Barr Virus.

In your good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res

 

Elyn Jacobs is a holistic cancer strategist and speaker specializing in the prevention and treatment of cancer. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in person.

 

This information is for educational purposes only and is not a recommendation to forgo anti-hormone therapy. It is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist and make your own decisions.  The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link, and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

Follow Elyn on LinkedIn

 

Broccoli and Watercress Sprouts Fight Cancer

In Anticancer foods, foods for colon cancer, foods for breast cancer, Cancer, Uncategorized on February 27, 2017 at 9:43 am

It is well known that cruciferous vegetables such as broccoli and watercress contain powerful anticancer compounds. But did you know that eating their respective sprouts can supercharge the health benefits? In sprout form these little three to four day old plants contain almost 100 times the level of cancer-fighting sulforaphane than the mature plants. The phytonutrients in these sprouts upregulate antioxidant enzymes and detoxification processes which clear toxic compounds from the body. And, that is just the beginning—read on to find out how sprouts knock the socks off cancer.

 What’s in a Sprout

Isothiocyanates (ITCs), such as sulforaphane, are sulfur-containing compounds found in cruciferous vegetables. They support matrix metalloproteinase-9 (MMP-9) activity which reduces the breakdown of connective tissue within a cell that impede the expansion of existing tumors. Matrix MMP-9 plays important roles in tumor invasion and angiogenesis. Secretion of MMP-9 has been reported in various cancer types including lung, colon, and breast cancer.

ITCs also kill off cancer cells, including cancer stem cells, which is essential for combating cancer metastases. Isothiocyanates restrain certain pro-inflammatory compounds that are associated with chronic inflammation and cancer.

The ITC sulforaphane helps support the anti-inflammatory Nrf2 pathway which protects cells against oxidative and free radical activity. It supports the detoxification process by inducing Phase 2 detoxification enzymes, inhibiting the activation of pro-carcinogens, and  by boosting cellular glutathione levels.  Sulforaphane promotes cancer cell death and inhibits cancer cell proliferation. It also supports the immune system and in particular, increases Natural Killer Cell activity.

Sulforaphane also inhibits Helicobacter pylori, the bacterium that increases one’s risk of stomach and colorectal cancer.  It is also anti-viral and has been found effective against the Epstein Barr Virus.

Quercetin, another potent antioxidant highly concentrated in sprouts, is a strong anti-inflammatory and prevents tumor cell growth.  It also aids in the removal of excess estrogen from the body — it stimulates liver function to detoxify estrogen and other carcinogenic agents.

Lutein is another powerful antioxidant that neutralizes cancer-causing free radicals (it is also essential for many things, including eye health, protecting against macular degeneration, and for maintaining strong eye tissue). Lutein (and zeaxanthin) may be beneficial to cardio health by preventing hardening of the arteries.

Glutathione has been labeled the ‘mother of all antioxidants” due to its incredible ability to disarm free radicals, detoxify the body, and boost the immune system.

Broccoli Sprouts

broccoli-sproutsBroccoli sprouts are extremely high in cancer fighting activity, particularly against lung, colon, and breast cancers. Compounds in broccoli speed up the removal of estrogen from the body, helping to suppress breast cancer. They also target cancer stem cells, the cells responsible for metastasis.

Broccoli sprouts contain a high amount of the cancer-busting and immune boosting substance sulforaphane. They are also abundant in quercetin, glutathione, beta carotene, indoles, vitamin C, lutein, glucarate, and the metabolic substance DIM, which is a natural aromatase inhibitor.

Broccoli sprouts are rich in cholesterol reducing fiber and have anti-viral and anti-ulcer activity. They are also a super source of chromium that helps regulate insulin and blood sugar.

 

Watercress Sproutswatercress-sprouts

Sometimes called peppergrass, watercress is delicious and pungent. It is also one of the most nutrient-dense foods known. It is rich in beta-carotene and other carotenoids, including lutein. Watercress also offers significant quercetin, EGCG (Epigallocatechin Gallate), flavanols such a kaempferol, lycopene, idole-3 carbinol (13C), sulforaphane, as well as DIM. It is a good source of riboflavin, vitamin C, A and K, calcium, magnesium, vitamin E, and contains trace amounts of omega 3’s. Watercress is one of the best food sources of iodine for vegans.

Watercress also contains a high amount of PEITC (phenylethylisothiocyanate) which has been shown to protect DNA from damage. PEITC reduces the growth of breast cancer cells, triggers apoptosis (cancer cell death), and decreases angiogenesis. It inhibits the growth of HER2 expression as well as cancer metastasis.

PEITC (also found in some other cruciferous vegetables, including broccoli) deactivates mutant p53 in tumor cells but leaves normal p53 alone. P53 regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way. A mutation in p53 is a permanent change in the nucleotide sequence of DNA. Loss of p53 function can be deleterious, and about 50% of all human cancers have a mutated p53 gene.

Watercress has antioxidant, antigenotoxic (the process by which chemical agents damage genetic information within a cell causing mutations), and anti-inflammatory properties.

Studies show that a regular intake of watercress has been associated with protection against breast, colon, and other cancers.

Watercress and broccoli affect all stages of cancer: initiation, proliferation, and metastasis. So, what’s not to love about these sprouts? Plus, it is a lot easier to consume a handful of sprouts than it is to down a pound and a half of broccoli or an enormous plate of watercress– which, for example,  is the amount it would take to get an equivalent amount of sulforaphane.

Add sprouts to your smoothies; use on sandwiches, on top of pizza, in salads, and as a garnish for soups. I make wonderful gluten-free pizza crusts using cauliflower or garbanzo bean flour, and pile the pizza high with arugula and sprouts just before serving.  Yum!

Just a reminder that while  eating cruciferous vegetables is a important for optimal health, it is necessary to have sufficient iodine in the diet when consuming high quantities  (including DIM).

Can’t find sprouts locally?  Grow your own–Year-Round Indoor Salad Gardening: How to Grow Nutrient-Dense, Soil-Sprouted Greens in Less Than 10 days

Curcera-SGS is an excellent supplement if you cannot find or grow broccoli sprouts.

Found this article helpful? Please let the elves know:

Thanks!

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

Follow Elyn on Facebook
Follow Elyn on LinkedIn

carl-o-helvie-lung-cancer-book

You Can Beat Lung Cancer: Using Alternative Interventions

#1 Best Seller on Amazon for Lung Cancer Books