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Archive for the ‘Estrogen’ Category

Natural Ways to Balance and Manage Hormones for Breast Cancer

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer diet, Anticancer foods, foods for colon cancer, foods for breast cancer, aromatase inhibitors, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, Estrogen, Estrogen and Breast Cancer, Hormone Balance, Integrative Oncology, Natural Alternatives to Aromatase Inhibitors, Natural Aromatase Inhibitors, Uncategorized on August 4, 2020 at 7:17 am

Hormone imbalances occur when we have to much or too little of a hormone in your bloodstream. While your body secretes about 50 different hormones that control many critical functions, for the purpose of this article, I will be discussing only estrogen and progesterone. When estrogen is high and progesterone is low, we have a condition known as estrogen dominance. Estrogen dominance is often a strong risk factor for breast cancer. Fortunately, there are many natural ways to balance the hormones and manage risk of cancer.

Even small hormonal imbalances can create side effects, including increased risk of breast cancer. What women with breast cancer hear most from their doctors is that estrogen is the villain, the cause of our cancer. However, while estrogen can fuel breast cancer, there is more to the story. Estrogen can fuel a tumor’s growth, but progesterone may put the brakes on that growth.

To be clear, estrogen is not bad, and in many cases, should not be reduced without due care. Estrogen plays a major role in numerous processes including blood sugar balance, as well as bone, eye, and heart health. But it needs to be balanced by progesterone, something that drops dramatically with age and increased stress.

To recap an article I wrote for The Truth About Cancer, estrogen and progesterone receptors are proteins found within many of the cells of our bodies, including cells in the breasts. Both receptors are directly involved in switching genes on and off − some 470 different genes. When estrogen and progesterone are present, these hormones stick to their respective receptors. They can then attach to specific regions of our DNA and turn genes on or off, changing the cell’s behavior.

Hormone receptor-positive breast cancers have many hormone receptors. In the case of breast cancer, tumor cells become overly sensitive to estrogen. When estrogen activates its receptor, it turns on a panel of genes that tell cells to keep dividing, encouraging tumor growth. However, the body also has progesterone receptors. When breast cancer cells have working progesterone receptors, and when there is sufficient progesterone available, progesterone will slow down estrogen-fueled growth and division of these cells. According to the late John Lee, Md, author of What Your Doctor May Not Tell You About Breast Cancer, when progesterone receptors are activated by progesterone, they attach themselves to the estrogen receptors. This essentially puts the brakes on the estrogen receptors, telling them to stop turning on genes that promote the growth of cancer cells, and turning on genes that promote the death of these cells.

A 2016 study led by Cambridge-based Cancer Researcher Dr. Jason Caroll of the University of Adelaide in Australia found that progesterone, via the progesterone receptor, is affecting how the estrogen receptor works. He found that the progesterone receptor actually ‘reprograms’ the estrogen receptor, changing the genes that it influences.[i]

Importantly, Carroll found that progesterone seems to cause cancer cells to stop growing as quickly. That said, what I am referring to is natural progesterone. While natural progesterone has an anticancer effect, synthetic progesterone does not and can actually make cancers more aggressive and deadlier. Further, synthetic progesterone does not activate tumor suppressor gene p53 when it attaches to progesterone receptors. P53 is a repair gene, which protects cells from becoming cancerous.

Toxic Substances Act Like Estrogen

We are bombarded daily with chemicals in the air, our food, and the products we use in our home and on our bodies. These chemicals, also known as xenoestrogens, are considered endocrine or hormone disruptors because they interfere with the production of hormones. They cause wide-ranging damage in the body. For example, bisphenol A (BPA) and bisphenol S (BPS), found in plastics, can liners, cash register receipts and most paper products mimic estrogen and can disrupt multiple hormonal pathways. Unlike our own estrogen, chemical estrogens (xenoestrogens) are particularly harmful. Read more HERE.

Fortunately, there are many natural approaches to ease hormones back into balance and reduce your risk of breast cancer.

Natural Approaches for Balancing Hormones

Let’s take a look at some herbs and natural approaches to balancing hormones.

Phytoestrogens modulate estrogen levels. Phytoestrogens work similarly to tamoxifen, blocking the effects of estrogen in breast tissue.[ii]

They act more like estrogen blockers than like estrogen; they modulate the production, availability, and action of hormones and slow down cell division. This is important as many oncologists illogically warn women to avoid them.

Phytoestrogens bind preferentially to estrogen receptor sites in the body. However, they are 99% weaker than our own natural estrogen, which means that they have very little estrogenic effects in the body. It also means that by binding to the receptors, more aggressive natural estrogen or xenoestrogens from the environment will be less able to bind to the receptors. Therefore, phytoestrogens might limit the negative estrogenic impact of those estrogens. Instead of fueling estrogen-dependent cancers, phytoestrogens tend to reduce the risk of these cancers. Even the NCI (National Cancer Institute) acknowledges that the plant-based hormones may have anticancer effects.[iii]

Meanwhile, if you are post-menopausal with very low estrogen levels, phytoestrogens may help reduce the resulting effects, such as bone loss, eye damage, and heart damage. Soy and flaxseed are two of the most powerful phytoestrogens, but herbs such as red clover, sage, hops, and fenugreek are also helpful.

Soy blocks cancer-promoting estrogens from attaching to the estrogen receptors on breast cells. It has also been shown to stop tumor growth, prevent metastasis, and shut off new blood vessels in growing tumors.  Fermented soy, such as tempeh and miso are preferred over unfermented versions such as tofu. This is because the fermentation process increases free radical scavenging activity and removes the nutrient blocking effect that soy can have—the phytic acid in unfermented soy can block absorption of key minerals such as magnesium and zinc. Soy in a highly processed form (like soy protein isolate or soy protein concentrate) should be avoided as they have the greatest ability to block nutrient absorption. Due to the fact that most soy is genetically altered, it is highly recommended to consume only organic and non-GMO. (My only issue with tempeh is that it is commonly ‘shrink-wrapped’ in plastic’)

 Flaxseed modulates the production, availability, and action of hormones—and does so much more (flax –and sesame seeds– offer anti-cancer lignans which can significantly reduce tumor growth by increasing cell death and decreasing the growth of new blood vessels that allow cancer to advance). As for hormones, the lignans in flax lower the production of estrogen by blocking the aromatase enzyme (similar to aromatase inhibitors) and block the estrogen receptors (similar to Tamoxifen). When lignans are consumed, intestinal bacteria convert them into enterolactone and enterodiol, weak estrogens. They attach to estrogen receptors, stimulate them weakly and block estrogen binding. This prevents estradiol or estrone from attaching to the estrogen receptors and strongly stimulating them, and includes not just the estrogen we produce, but also environmental toxins, thus making breast tissue more resistant to these environmental toxins.  One long-term study reported that relatively high circulating enterolactone levels are associated with lower risk of death after an early-stage breast cancer diagnosis. Please read my articles — Flaxseed: Better Than Tamoxifen and Demystifying Flaxseed and Estrogen.

Licorice root and Vitex (also known a chaste tree berry), focus more on raising progesterone. Progesterone tends to fall sharply as we age and are no longer ovulating. While bio-identical progesterone supplement progesterone directly, licorice root and vitex are thought to lower estrogen levels while simultaneously raising progesterone, thus helping to relieve hormone imbalance and estrogen dominance. (use caution if you have elevated blood pressure)

Combining vitex with stress-reducing adaptogens such as ashwagandha or Schisandra can be helpful as stress tends to lower progesterone. Some people have reported that vitex worsens depression, so discontinue if that happens. (Do not take Schisandra with Tamoxifen).

Red clover can bind weakly to estrogen receptors, standing in for estrogen when levels are low and lowering high estrogen levels, helping to balance the hormones and correct estrogen dominance.

White peony root, something often used in traditional Chinese medicine, also supports progesterone. Black cohosh seems to support healthy estrogen levels not by actually boosting estrogen, but by improving brain-ovary communication and modulating cell receptors. This can help reduces menopausal symptoms and ease depression.

Adaptogens such as maca support hormone balance and may boost libido and mood while decreasing anxiety.

Vitamin E is crucial to maintaining a healthy balance between progesterone and estradiol. Vitamin C plays an important role in preventing the degradation of steroid hormones into toxic and cancer-promoting metabolites. It also regenerates estrone and significantly regenerates progesterone.

Vitamin B6 has been shown to help increase levels of progesterone in the blood naturally. Magnesium is another key nutrient for increasing progesterone levels, as it plays an important role in maintaining a healthy hormonal balance in the body.

Probiotics support gut bacteria and improve digestion, helping to prevent constipation. This is important because when poop remains in the bowel for extended periods of time, excess estrogen is re-absorbed and re-circulated into the bloodstream. Plus, immune function depends on healthy gut microflora—and gut flora effects cancer genes too!

Consume GLA (gamma-linoleic acid), which is found in evening primrose oil and in hemp seeds.  Research shows that this type of omega-6 may support healthy progesterone levels.

Get more sleep—lack of sleep disturbs hormone balance. Try to get to sleep by 10 pm as melatonin production peaks between 10 pm and 2 am. Melatonin stimulates tumor-suppressor genes and counteracts the effects of aggressive estrogens, including xenoestrogens.  Cell phone EMF exposure can suppress the production of melatonin—limit use before bed and do not keep near your bed, and preferably out of your room.

If you are overweight, lose weight. Fat cells increase estrogen production. Increased weight often means insulin resistance and this is a common cause of high estrogen levels. Insulin resistance leads to an up regulation of the aromatase enzyme leading to high estrogen. Plus, over-consumption of calories leads excessive free radical formation. Free radicals damage cells and cause genetic mutations, which ultimately can lead to cancer.

Your Liver and Estrogen

Be sure that your liver and gut are functionally efficiently as estrogen is metabolized in the liver and excreted out of the bowel. Think of your liver as a filter that neutralizes toxic substances so that they can safely be excreted from the body.  By enhancing liver function, more estrogen is broken down in the body, reducing the overall estrogen load.

When the liver and colon have become sluggish due to low thyroid function, stress, and an overburden of toxins, the body cannot break down and remove excess estrogen adequately from the system. The excess unbalanced estrogen gets stored in the fat cells of breast tissues when it is not properly eliminated. Nutrients derived from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts as well as sulforaphane supplements  help with the detoxification of estrogen through the liver (Read about Sulforaphane HERE)

Supporting the liver with supplements such as N-acetylcysteine (NAC), Milk Thistle, and SAMe can be very helpful. DIM and Indole-3Carbinol,  two other extracts of cruciferous vegetables, can encourage proper metabolism of estrogens in the body and help to clear excesses and xenoestrogens from the system. Dandelion, herbal bitters, artichoke extract, also support the liver in detoxifying, metabolizing, and excreting hormones. Fiber binds to bile (liver’s waste) to support excretion.

For more on detoxification and liver function, please request my Estrogen and Detoxification Handouts or visit the Estrogen Management and Detoxification Sections on my supplement page.

Natural Aromatase Inhibitors:

Pumpkin seeds, button mushrooms, and supplements such as DIM, vitamin K2, calcium d-glucarate, zinc, gingko biloba, and  grapeseed extract (organic please)  are natural aromatase inhibitors. Research done at the State University of New Jersey demonstrated that a 2% concentration of rosemary extract was able to inactivate excess estrogen[iv] Apigenin – found in parsley, celery, and chamomile—is another aromatase inhibitor and is a potent estrogen metabolizing compound.

Read more on Natural Aromatase Inhibitors HERE.

Note: while herbs are powerful, it may take at least 4 months of use to begin to show benefits. Further, herbs can interact with one another or with various medications, so always consult your doctor before use.

Testing: If you are looking to lower your estrogen levels, you may want to test your hormone levels first. You can be low on estrogen and still be estrogen dominant, so it may be important to acquire this information. Also note that it is possible to have ‘normal’ estrogen levels when tested via blood or saliva, but still have high estrogen symptoms.  This can happen if your body is not detoxifying estrogen correctly.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150resElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit http://www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment. This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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[i] http://scienceblog.cancerresearchuk.org/2015/07/08/solving-a-breast-cancer-mystery-why-do-double-positive-women-do-better/

[ii]https://marylandoncology.com/disease-drug-info/glossary/P/P1080/

[iii]   https://marylandoncology.com/disease-drug-info/glossary/P/P1080/

[iv] https://pubmed.ncbi.nlm.nih.gov/9806165/

Options for Breast Cancer: Making the Best Choice for YOU

In Alternative Cancer Therapies, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, antioxidants, aromatase inhibitors, Breast Cancer, Cancer, Cancer Coach, EMFs and breast cancer, EMFs and Health Risks, Energy Healers, Epstein-Barr Virus, Estrogen, Estrogen and Breast Cancer, Healing Cancer Naturally, High Dose Vitamin C and Cancer, Integrative Oncology, Mind Body Therapies for Cancer, Natural Alternatives to Aromatase Inhibitors, Radiation, Radiotherapy for breast cancer, Tamoxifen, Uncategorized on January 23, 2020 at 2:48 pm

If you don’t know your options (for breast cancer) you don’t have any. That is my motto, and I can’t tell you how important it is to take control of your treatment plan. It is imperative that you make informed choices, not fear-based choices for your breast cancer.

In October, 2014 I found that my previously stage 1 cancer had spread to my lymph nodes. I was subsequently diagnosed as stage 3 (ER+). I have told this story before, but am sharing it again as I want people to know there are many paths to healing breast cancer.

Importantly, there are many reasons why people get cancer and why it returns. Resolving those reasons can make all the difference in survival.

Declining Chemo and Radiation

My choice does not necessarily have to be your choice. I was fortunate that I had a holistically-minded oncologist who supported my choices. A world-renowned integrative oncologist, he believed healing cancer often required both Eastern and Western medicine. This typically involved conventional methods used alongside holistic mind-body therapies, supplements, dietary changes, and more. Most of all, like me, he believed getting to the reason for the cancer is a major part of treating it.

Given my new diagnosis, my oncologist was legally compelled to recommend chemotherapy. I know that if had chosen the conventional chemo (or even the low dose chemo he suggested after I declined traditional chemo) it would have been a reasonable option. I know that if I had chosen it, he would have done everything he could to make the treatment work better with less negative effects.

That said, it did not resonate with me. Part of that came from my mother dying not so much from her cancer, but from the treatment (he was not her doctor). The rest came from my innate feeling that it was not right for me, and that it would not resolve the reason for my recurrence. My oncologist agreed that chemo was not necessarily the best option for me. He said was glad that I opted out of radiotherapy, and supported my choice to skip the aromatase inhibitors. He offered a few other options, but none seemed to resonate with me. I will forever be grateful for his support.

My Choices for Breast Cancer

Instead of the options presented, I chose a protocol put together from my years of research and conference attendance, leaning on input from my oncologist and an alternative doctor friend of mine.  I do believe that most of us have more to learn than we will ever know, and the experience has only strengthened my ability to help my clients through their cancer.

You can read about my protocol HERE. A major part of my healing (and most likely one of the major reasons for the recurrence) was resolving past emotional traumas, which you can read about HERE.

Read about natural alternatives to aromatase inhibitors and tamoxifen HERE.

To listen to me talk with the Templeton Wellness Foundation about my choices, click HERE.

Goals for Healing:

  • Don’t be fooled that your own estrogen is the reason for your breast cancer (it plays a role, but not the lead).
  • Target viruses such as Epstein Barr, which plays a significant role in breast cancer (and you may not realize you have it)
  • Clean house: remove toxic products and people from your life
  • Eat clean without deprivation
  • Take targeted supplements
  • Resolve the traumas that are getting in the way of your healing and may well be at the root cause of your breast cancer
  • Avoid EMFs and take protective measures; for recommendations, click HERE
  • Believe you can and will heal–the power of the mind is incredible!
  • Walk in nature; soak up the positive vibes and the sun
  • Live, laugh, love and smile!
  • If you don’t know your options, you don’t have any

You have many options for healing from breast cancer. I implore you to be informed and make educated, confident choices.  Know that there are many natural substances that can make conventional therapies work better and with less toxicity. You can read about these on my Shop page. To schedule a consult, please click HERE.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

 DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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Eternity: Quite Possibly the Best Bio-Identical Progesterone Cream

In Alternative Cancer Therapies, Alternatives to Anti-Hormone Therapy For Breast Cancer, aromatase inhibitors, Bio-Identical Hormones, Boosting Estrogen, Breast Cancer, Cancer, Cancer Coach, Estrogen, Estrogen and Breast Cancer, Healing Cancer Naturally, Hormone Balance, infertility, insomnia, menopause, Natural Alternatives to Aromatase Inhibitors, Tamoxifen, Uncategorized on January 16, 2020 at 9:05 am

Progesterone is vital for a woman’s body. It is the key to many aspects of female health, and often thought of as one of the most important hormones. Unfortunately, most women have very low levels of progesterone which can result in estrogen dominance. This can wreak havoc in the body. Eternity bio-identical progesterone cream might be the answer.

Eternity Organics Bio-Identical Progesterone Cream

Eternity Organics Bio-Identical Progesterone Cream

Why You NEED Progesterone

Progesterone is the precursor to other important hormones, including estrogen and testosterone. These hormones play a significant role in female health, influencing everything from cognitive function, menopause, fertility, helping the uterus to grow during pregnancy, normal breast development during puberty, and so much more, including breast cancer prevention. Importantly, the body depends on the right balance of these hormones in order to function properly.

 

 

 

Symptoms of progesterone deficiency include:

  • Unexplained fatigue and low energy
  • Intense PMS symptoms such as cramps and moodiness
  • Dizziness
  • Difficultly sleeping
  • Irritability
  • Ovarian cysts
  • Fibrocystic breasts
  • Mood swings
  • Hot flashes
  • Low libido
  • Irregular menstrual cycles
  • Weight gain
  • Fibroids
  • Endometriosis
  • Thyroid dysfunction
  • Infertility and miscarriage
  • Uterine bleeding
  • Breast and other cancers

Some women have been progesterone-deficient most of their lives, whereas others found themselves in this predicament around age 45 or so. Regardless, it is imperative that we increase progesterone and in turn, balance the hormones. Clearly the list above gives you enough reasons.

Raising Progesterone

Foods can help raise progesterone include broccoli and other cruciferous vegetables, beans, and nuts. Things that deplete progesterone are stress and excessive exercise (which cause the body to produce stress hormones instead of progesterone).

It is important to understand the difference between progesterone that is made by the body or is molecularly similar to one’s own natural progesterone and synthetic progesterone, which has been molecularly altered (the prescription one). This is why many women opt for bio-identical progesterone.

However, as discussed in a previous article,  Could Aromatase Inhibitors Actually Increase One’s Risk for Breast Cancer prescription bio-identicals can be problematic. According to Dr Mache Seibel, M.D., author of The Estrogen Window, you have to be careful with compounded bio-identicals. This is because typically the progesterone in many compounded formulas tends to be 60-80% lower than ordered and estrogen 80-200% higher than ordered which can result in increased estrogen dominance. This could raise your risk of hormone-driven cancer.

The answer lies in safe and effective bio-identical topical creams. There are a few good ones on the market, but one I recently discovered that has some great research behind it and no harmful chemicals is Eternity Organic Progesterone Cream.

Please take a few moments to view this informative clip on progesterone and Eternity Bio-Identical Cream:

To Order Eternity, click HERE

According to their website, Eternity does NOT contain Chinese Progesterone (only natural, American-made progesterone) and is made from all plant-based, natural ingredients.

Eternity Organic Bio-Identical Progesterone Cream

Eternity Organic Bio-Identical Progesterone Cream

  • Cruelty-Free
  • Hypo-Allergenic
  • GMO-Free
  • Petroleum-Free
  • Paraben-Free
  • 100% Plant-Derived
  • Sustainably Sourced

Regarding breast cancer,  natural progesterone is not to be feared. In fact, it is widely believed that estrogen can only fuel breast cancer in the absence of progesterone. In essence, progesterone puts the brakes on cell proliferation and growth. Of course, chemical estrogens (also known as xenoestrogens) such as BPA (bisphenol A) and other chemicals often found in home and personal care items are another story. They DO fuel breast cancer. Unlike natural estrogen which is flushed out of the body after 12 doing its job, xenoestrogens are stored in fat cells, increasing the risk of cancer (time to clean those out of your life). For more information specific to breast cancer, please read my article Progesterone and Breast Cancer

For more information on the damages of BPA and BPS please read: BPA: The Bathroom Toxin that Fuels Breast Cancer 

To Order Eternity bio-identical progesterone cream, click HERE

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Important Disclaimer: Elyn Jacobs Consulting, Inc. does not provide endorsement for the content, claims, or products discussed in this article. This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

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Could the Natural Alternative to Tamoxifen and Aromatase Inhibitors be in Your Refrigerator? Part II

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, antioxidants, aromatase inhibitors, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, cancer stem cells and recurrence, Estrogen, Estrogen and Breast Cancer, Natural Aromatase Inhibitors, prostate cancer, SERMS, Tamoxifen, Uncategorized on November 15, 2019 at 9:07 am

Synthetic selective estrogen receptor modulators (SERMS) such as tamoxifen and pharmaceutical aromatase inhibitors are often recommended for ER+ breast and other hormone-driven cancers, but they have significant adverse effects. Is it possible that natural plant products can perform the same function without the risks and damage of pharmaceuticals? Research says they can.

While estrogen plays many important beneficial roles in humans, the proliferation of ER+ breast cancer cells can sometimes be enhanced by estrogen (especially in the absence of progesterone), which may induce multiple processes involved in cell survival and cell cycle progression. Beyond the estrogen dominance that comes from a lack of progesterone, it is not necessarily our own estrogen at fault, but more likely xenoestrogens — the chemical estrogens, environmental hazards such as BPA and BPS — Bisphenol A and S.

However, to add clarity to the estrogen equation that oncologists speak of, the body has two different estrogen receptors, ERα (alpha) and ERβ (beta). ERα has a proliferative effect, and ERβ acts as a negative regulator of ERα in breast cancer cells, counteracting the proliferative effect of estrogens. Importantly, plant estrogens (phytoestrogens) preferentially interact with ERβ and display high specificity toward ERβ transactivation. Phytoestrogens, also known as phytochemicals, are synthesized from plants and vegetables. They show low estrogenic activity or anti-estrogenic activity with anti-proliferative effects that studies show offer nutraceutical alternatives to pharmaceutical anti-hormone therapies for various cancers.[ii]

For the men reading this article (including those with breast cancer), androgens and estrogens also influence the development and progression of prostate cancer. Research shows that phytoestrogens such as soy could be used alone or in conjunction with anti-hormone therapies for prostate cancer to target metabolic pathways involved in androgen and estrogen syntheses and epigenetic modifications of DNA to promote tumor-suppressor genes.[iv]

In a nutshell, phytoestrogens may be useful as substitutes for breast cancer treatments such as tamoxifen or aromatase inhibitors, and could be extremely helpful for other hormone-related cancers.

The Role of Phytoestrogens as Replacements for SERMs and Aromatase Inhibitors

It is well-established that many foods and natural products have beneficial effects on ER+ breast cancer as well as other hormone-driven cancers.  Pytoestrogens are structurally similar to our own estrogen, but functionally are weakly estrogenic (weakly mimicking estrogen) or antiestrogenic (blocking estrogens’ effects). They have been researched extensively for their role in the interaction with estrogen receptors. The beauty is that they block the receptors from more volatile estrogens.  As such, they deserve consideration in preventive and therapeutic settings for the intervention of cancer initiation and progression.

Studies show that phytoestrogens may provide an alternative or complementary approach to anti-hormone treatments. For example, 2017 research published in the International Journal of Molecular Sciences cited many studies confirming that an important application of phytoestrogens is that they could be used as an alternative to the SERMs.[iii] In general, phytoestrogens act as aromatase inhibitors by decreasing aromatase gene expression and inhibiting the aromatase enzyme.   

Some of the more powerful phytoestrogens include flax and sesame seeds as well as whole soy. 

Flax and sesame seeds have anticancer, breast tumor-reducing effects. Both lignans are metabolized to estrogen-like enterodiol and enterolactone, and reduce cell proliferation and apoptosis.[xiv] While each works a bit differently, both may be useful as an effective adjuvant therapeutic agent against tumor development and progression, and therefore, could be used in the prevention and/or treatment of various types of cancer. Studies show that higher intakes of lignans such as flax and sesame seeds are associated with a reduced risk of breast cancer. Flax seed works with tamoxifen to inhibit breast cancer tumor growth, so if you choose to take tamoxifen, know that you can also benefit from flax.  

I have written extensively on the benefits of flax seed, but to recap, a few of the benefits of flax are the following:

  • Decreases cell proliferation rates and inhibits tumor growth in ER+ cancers
  • Decreases angiogenesis (blood supply for tumors) and increases apoptosis (cancer cell death)
  • Influences ER-negative and ER-positive tumors by decreasing insulin-like growth factor-1 (IGF-1), epidermal growth factor receptor (EGFR), HER2 and the vascular endothelial growth factor (VEGF) which supports angiogenesis
  • Reduces growth and metastasis of ER-negative and triple negative breast cancers
  • Favorably influences tumor suppressor genes

For more on flax seed and breast cancer, please read some of my other posts, such as  Demystifying Flaxseed and Estrogen and Flaxseed, Better Than Tamoxifen for Breast Cancer.

Soy: Numerous studies indicate that genistein, the most abundant isoflavone present in soybeans, has anti-proliferative effects on various cancer cells, including prostate, ovarian, and breast. Like other phytoestrogens, genistein interferes with the effects of estradiol by binding to estrogen receptors. This is good as soy may also inhibit inflammation and boost anticancer immune responses, while other estrogens do not. The following are a few key findings of soy[v]:

  • Inhibits NF-kB activity in prostate, breast, lung, and pancreatic cancer cells. Nf-kB plays a crucial role in immune response, inflammation, cell growth and survival.
  • Selective tyrosine kinase inhibitor impeding angiogenesis, a major factor in cancer growth and proliferation. Tyrosine kinases play important roles in cell proliferation, survival, migration and differentiation are often altered in cancer cells, leading to malignancy
  • Induces cancer cell death (apoptosis) in several cancer cell lines, including prostate, ovarian, and breast cancer
  • Modulates EGF (epidermal growth factor) which has been implicated in the development and growth of many types of cancer cells
  • Long-term consumption seems to result in a decreased response to stimulation by estradiol[vi]

Please note that soy consumption is somewhat controversial. Please work with your coach or medical professional to see if soy consumption is right for you.

More Notable Phytoestrogens                                                                            parsley root

  • Apigenin is a natural flavonoid commonly found in fruits and vegetables such as parsley, celery, thyme, chamomile tea, and oranges. The chemical structure of apigenin is similar to estrogen and as such it mimics estrogen. 2107 research indicates that phytoestrogens such as apigenin and resveratrol have the therapeutic potential act like SERMs and could be considered in the development of therapeutics for breast cancer and brain disease.[vii] Extensive studies show that apigenin has potent antioxidant and anticancer activities in ER-positive and ER-negative breast cancer. Apigenin also inhibits proteasome, which certain cancer cells need for survival. By inhibiting proteasome, phytoestrogens such as apigenin induce apoptosis in prostate, breast, and many other cancer cell lines.[viii]
  • Pau d’ Arco exhibits selective anti-proliferative effects in carcinoma cell lines. A study performed at the Strang Cancer Prevention Center in New York found that the anti-proliferative effects of herbal medicines such as pau d’arco may correlate with down-regulated estrogen responsive genes and up-regulated apoptosis-specific genes. The researchers believe their data validates the need to prioritize efficacious herbal medicines and concluded that phytoestrogens such as pau d’arco may provide an alternative or complementary approach to endocrine therapy for breast cancer.[ix] Read more
  • Broccoli: The sulforaphane in broccoli (particularly in broccoli seeds and sprouts) has been found to inhibit proliferation and down-regulates hormone receptor expression in MCF-7 cells. Sulforaphane also passes the blood brain barrier and targets cancer stem cells. If you cannot find sprouts locally, I recommend a supplement.sprouts
  • Luteolin and Naringenin: Flavonoids, especially flavones such as luteolin and flavanones such as naringenin are potent aromatase inhibitors. [x] Luteolin has also been found to down-regulate aromatase gene expression. Luteolin is found in celery, thyme and chamomile tea. Some rich sources of naringenin include bergamot, grapefruit, tomatoes, and tart cherries.
  • Quercetin, found in abundance in food sources such as apples, onions, tea, and red wine, has been reported to have strong antioxidant, anti-inflammatory, antiviral, and anticancer effects. It has the ability bind at high affinity to estrogen receptors, resulting in inhibition of estrogen-regulated cell growth and proliferation[xi]
  • Hesperetin, found in citrus fruits and essentials oils, exerts it anticancer actions by inhibiting cell proliferation, inducing apoptosis, and by regulating aromatase activity and oxidative stress. Although hesperetin is unable to bind to ERs, it is effective in inhibiting cell proliferation of ER+ breast cancer and dramatically decreasing tumor size and other actions. Hesperetin has also been found to reduce serum estrogen levels and down-regulate estrogen target genes and estrogen metabolism-related genes.[xii]. Try putting a drop or two of lemon essential oil in your water, or grating the peel of an organic lemon.
  • Black seed contains thymoquinone, a phytochemical compound found in plant Nigella sativa. It has been found to initiate apoptosis, improve estrogen metabolism, and regulate signally pathways in breast cancer.
  • Vitamin E inhibits cell proliferation, down-regulates the expression of ERα, ERβ, COX-2, and serum estrogen levels (should always be mixed tocopherols, not just d-alpha.
  • Red Clover binds to estrogen receptors, inhibits cell proliferation, and initiates apoptosis in ER+ breast cancer cells.
  • Ellagic acid, a dietary flavonoid present in berries, grapes, pomegranates, and nuts, inhibits cell proliferation and promotes apoptosis in ER+ breast cancer cells.
  • Eugenol, a compound found in clove oil, inhibits cell proliferation and initiates cancer cell death in both ER+ and ER- breast cancers. Excitingly, one study done in Indonesia found that eugenol  is a potent ERa antagonist. The researchers indicate that not only does it work just like tamoxifen, but it may actually work even better.
  • This list is  not inclusive: There are many more powerful phytoestrogens. For more cancer-fighting alternatives to pharmaceuticals, please read my articles on Natural Alternatives to Aromatase Inhibitors and Natural Alternatives to Tamoxifen.

Phytoestrogens can be our friends, but know that herbs are powerful. I have no concerns with food-based phytos, but do take care with extracts. They are best rotated so as to maximize benefits, reduce the chances of resistance, and avoid interactions. Drugs, of course, are often even more dangerous, yet are routinely prescribed.

                               Trust me, I’m a doctor” Peter Gøtsche

I interviewed Peter Gøtsche, author of Deadly Medicines and Organised Crime, on my radio show a few years back. Amazing man, whose controversial views have since gotten him tossed from the Cochrane Collaboration, which he co-founded. Sadly, there are many who wish to silence the voices who speak against Big Pharma.

Like me, Gøtsche worries that most people let their doctors make the decisions for them, but the evidence tells us that we should be cautious. He is a strong advocate for the avoidance of drugs and while not against medical interventions, believes one can not just blindly follow the orders of the medical community.

Notably, there is tremendous variability in the metabolic processing of phytoestrogens and pharmacological drugs, thus establishing the difficulty and complexity of this topic. The bottom line is that it extremely important that one understand that it may not make logical sense to attempt to poison one’s way back to health. Certainly drug therapies have worked for many. That said, NO ONE was every born tamoxifen or AI deficient, but over time we may become estrogen dominant, increasing our risk for cancer. It behooves us all to do our research and decide for ourselves whether drugs or holistic remedies are best, or even a combination of both.  

Estrogen plays many important roles in humans, so it may not make sense to arbitrarily take it away. If you are estrogen dominant (meaning out of balance with progesterone), you may want to consider a bio-identical progesterone cream (I like that one as it is paraben-free, soy-free, and Non GMO).

Read Part I of this article HERE.

Reminder: To get an additional $30 off on the online course for breast cancer,  Toxic Free Me, enroll now and use this LINK. This course will further delve into alternatives for anti-hormonal therapies.

An online course not right for you? Know that I am always there for individual consultations.  To inquire about a consult, please visit me HERE.

Life is a journey, just be sure that journey is on-course for a healthy life.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

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[i] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; Notably, there are numerous  crsos-references cited in this article that support the use of phytoestogens as nutraceutical anti-hormone therapies for various cancers.

[ii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[iii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/

[iv] https://www.ncbi.nlm.nih.gov/pubmed/27194038; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[v] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/#B61-ijms-18-01381; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[vi] https://www.ncbi.nlm.nih.gov/pubmed/8625449

[vii] https://www.ncbi.nlm.nih.gov/pubmed/28396216; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033666/

[viii] https://www.ncbi.nlm.nih.gov/pubmed/26771497; https://www.ncbi.nlm.nih.gov/pubmed/25408199

[ix] https://www.ncbi.nlm.nih.gov/pubmed/19578798

[x] https://www.ncbi.nlm.nih.gov/pubmed/21741436

[xi] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203161/#b9

[xii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[xiii] https://www.ncbi.nlm.nih.gov/pubmed/26614455

[xiv] https://elynjacobs.com/2016/02/28/flaxseed-better-than-tamoxifen-for-breast-cancer/; https://www.ncbi.nlm.nih.gov/pubmed/29032105; https://www.ncbi.nlm.nih.gov/pubmed/22136581

 

Could the Natural Alternative to Tamoxifen and Aromatase Inhibitors be in Your Refrigerator? Part I

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, aromatase inhibitors, Breast Cancer, Cancer, Cancer Coach, Emotional Healing, Estrogen, Estrogen and Breast Cancer, Uncategorized on November 14, 2019 at 9:59 am

Estrogen play an important role in overall health in humans—it protects your heart, lungs, eyes, brain, bones, skin, and hair, averts cognitive decline, and does so much more. Estrogen is also protective against adverse symptoms during the peri-and postmenopausal periods. But estrogens are known to stimulate cellular proliferation associated with certain cancers. Hence, if you have been diagnosed with a hormone-related cancer, your doctor may advise a synthetic selective estrogen receptor modulator (SERM) such as tamoxifen or a pharmaceutical aromatase inhibitor such as Femara (letrozole), Arimidex (anastrozole), or Aromasin (exemestane).

Of course, these pharmaceutical drugs come with a host of detrimental side effects. What’s a person to do?

Side Effects and Resulting Effects of Pharmaceutical Anti-Hormone Drugs

pills tamoxifenSome side effects of tamoxifen include severe muscle pain, weight gain, thickening of endometrial lining of the uterus, daytime sleepiness, nausea, edema, hot flashes, vaginal hemorrhage, increased risk of cataracts, acute glaucoma, and other eye issues. It is not recommended to take tamoxifen if you have impaired CYP2D6 enzyme, nor should you take medications that block the activity of CYP2D6, such as Benadryl, Prozac, Paxil, and Zoloft (these lists are not inclusive) during treatment. Tamoxifen has been declared a human carcinogen by the WHO, NIH and other authorities.

Side effects of aromatase inhibitors include damage to the heart, never-ending flu-like symptoms, hair thinning and loss, joint pain, stiffness and swelling, hot flashes, vaginal dryness, and headaches, a feeling of tiredness and lethargy, difficulty breathing, nails breaking down and peeling, memory fog, depression and mood swings, balance problems, sleep disorders, tightness of the chest, bone thinning, and more.

In the summer edition of Cure magazine, they spoke of a doctor who when asked why he didn’t tell his patient about the side effects of the prescribed hormonal therapy, replied “some women would not take the pill if they knew bout the side effects”. Incidentally, these were not listed on the medical paper that came with her bill.

Clinical trials have indicated that resistance develops with both tamoxifen and aromatase inhibitors. This is another major pharmaceutical problem and cause of serious concern to clinicians and patients.

So, again what exactly is a person to do?

The easiest and most logical answer is to eat copious amounts of phytoestrogens throughout the day.

Phytoestrogens are plant-derived naturally occurring compounds that have chemical structures similar to estrogens. Phytoestrogens have been found to decrease cancer risk by inhibiting aromatase activity and CYP19 gene expression (The aromatase enzyme is a product of the CYP19A1 gene).

Aromatase plays an important role in breast cancer as it converts androgens to estrogens in many human tissues, the result of which has been known to stimulate cellular proliferation in certain cancers. In the vast majority of breast cancers, estrogen levels play a role tumor growth and depend on the activity of CYP19.

Research performed in 2015 by the Department of Physiology and Developmental Biology and The Neuroscience Center at Brigham Young University, indicates that phytoestrogens act as aromatase inhibitors by decreasing aromatase gene expression and inhibiting the aromatase enzyme. Their findings emphasize that estrogens have a significant impact on health and that phytoestrogens (being of similar structure to 17β-estradiol) have strong potential as anticancer agents.[i]

The researchers concluded that phytoestrogens not only act as SERMs (as has been previously reported and I will get into in Part II of this post), but also have the ability to alter the activity of the aromatase enzyme. They go on to remind us that the inhibition of aromatase activity and gene expression represents a key mechanism of how phytoestrogens may contribute to decreased cancer risk and recurrence.

The important difference is that phytoestrogens do not initiate the cascade of negative effects of pharmaceutical drugs and as estrogen modulators, may stave off the negative effects of declining estrogen, making them effective in more ways than one. Further, unlike drugs, they offer significant cancer-fighting abilities. For example, the apigenin in parsley is known not only for its aromatase-inhibiting abilities, but also for promoting cancer cell death, including cancer stem cells. parsley

In Part II of this post I will discuss many different phytoestrogens—all of which play a significant roll in the management of hormone-related cancers. In the meantime, a few of my favorites are flax and sesame seeds, broccoli sprouts, including the seeds (sulforaphane), parsley (apigenin), and organic whole soy.

However, as a strong reminder, estrogen is not the biggest driver of cancer, at least not your own estrogen. Emotional and environmental toxins (including xenoestrogens such as BPA and BPS) are often at the root of it all, as well as the viral factor—it is imperative that you resolve these issues as well as anything that may have contributed to your cancerous environment.

Importantly, it is not always wise or even necessary to reduce estrogen (many post-menopausal women already suffer from low estrogen). This is especially true for very thin women as post-menopause, estrogen is no longer made in the ovaries, but rather from adipose tissue (fat, especially in the breasts and belly), of which they may have very little. (This is also why many doctors advise their patients to lose weight, if necessary). Thin women might benefit more by raising progesterone. Reminder that you have to be very careful with compounded bio-identicals; read more HERE.

Many of my followers have been asking about a safe  bio-identical progesterone cream (It is paraben-free, soy-free, and Non GMO). 

Read Part II HERE

Below are just some of the articles I have written on natural alternatives to tamoxifen and aromatase inhibitors:

Why You May Want to Reconsider Estrogen-Blocking Aromatase Inhibitors and Tamoxifen

Natural Alternatives to Hormone Therapy for Breast Cancer

What to Do if You Have Low Estrogen Levels and Your Doctor Prescribes an Aromatase Inhibitor

Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment

Managing Estrogen Naturally

Flaxseed, Better than Tamoxifen for Breast Cancer

Flaxseed, the Anticancer Power Seed

Alternatives to Aromatase Inhibitors

 

Reminder: To get an additional $30 off on Marnie Clarks’ online course for breast cancer,  Toxic Free Me, enroll now and use this LINK. This course will also delve into alternatives for anti-hormonal therapies.

An online course not right for you? Know that I am always there for individual consultations.  To inquire about a consult, please visit me HERE.

Life is a journey, just be sure that journey is on-course for a healthy life.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

Follow Elyn on LinkedIn

 

[i] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/

Pau d’arco for Breast, Prostate, Colon, and Other Cancers

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, antioxidants, Breast Cancer, Cancer, Cancer Coach, chemotherapy, CLA and Cancer, colon cancer, Epstein-Barr Virus, Estrogen, Estrogen and Breast Cancer, foods that target cancer stem cells, Healing Cancer Naturally, inflammation, prostate cancer, SERMS, supplements that target cancer stem cells, Tamoxifen, Uncategorized on November 1, 2019 at 8:56 am

Pau d’arco, also known as Taheebo, is extracted from the inner bark of several species of Tabebuia trees that grow in Central and South America. The medicinal uses of Pau d’arco (PDA) date back to 1873.  PDA has been used in South America to treat a wide range of conditions, including pain, ulcers, arthritis, fever, prostatitis, Candida, osteoarthritis, cough, influenza, herpes, diabetes, ulcers, warts, infections, allergies, and even cancer, particularly cancers of the breast, colon, lung, prostate, and malignant melanoma.

What the Docs Have to Say

Dr. James Duke of the National Institutes of Health (NIH) and Dr. Norman Fransworth of the University of Illinois have reported PDA contains active substances (such as β-lapachone and lapacho) found to be highly effective against various cancers. Dr Paulo Martin, a Brazilian medical researcher, reported that PDA has powerful antibiotic, virus and cancer-killing properties.[i] The late integrative oncologist Dr. Mitch Gaynor also used Pau d’arco with his cancer patients.

What the Studies Say

Scientists have discovered that compounds in PDA called naphthoquinones (mainly lapachol and beta-lapachone) are the reason for these impressive healing abilities. PDA also contains a significant amount of the antioxidant quercetin, which has been found to inhibit growth of cancer cells, including cancer stem cells. Some of the exciting cancer research on PDA:

  • Exhibits selective anti-proliferative effects in carcinoma cell lines, including ER+MCF-7 breast cancer cells[ii]
  • Inhibits the growth of estrogen receptor positive breast cancer cells and activates cancer-fighting genes[iii]
  • May block estrogen receptors [much like the SERM tamoxifen] as it is a powerful phytoestrogen [iv]
  • Effective against some bacteria, fungi, viruses (including Epstein Barr), and parasites that may be involved in cancerous processes
  • Induces cell death in prostate cancer lines[v]
  • Induces apoptosis independent of P53 expression; notably, over-expression of bcl2, a contributor for a number of cancers – including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, does not appear to inhibit the  B-lapachone in PDA[vi]
  • Inhibits angiogenesis, the ability of tumors to make new blood vessels in prostate and other cancers[vii]
  • Suppresses the growth and angiogenesis of lung cancer[viii]
  • Inhibits the growth of cancer in a wide range of cancers, such as breast, prostate, cervical, liver, lung, and colon* (see Quercetin below)
  • Appears to increase the effectiveness of chemo and decreases side effects

Research also shows that the lapachol in PDA may have the ability to stimulate the production of red blood cells in bone marrow, which could be helpful for those with low red blood cell counts (RBC). Pau d’arco is also thought to eliminate toxins in the body and purify the blood.

Enjoy Pau d’arco tea, tincture or capsules. Another good tincture is Pau D’ Arco Plus, which also contains dandelion and red clover. Use of PDA during pregnancy is not advised. A potent herb, PDA should be cycled – meaning a few weeks on and then take a break for a few weeks – or swapped out for another cancer-fighting herb. This is especially important for those taking drugs or herbs that thin the blood or for Candida, as resistant strains of Candida can develop.

Please also read my related published articles:

*Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment  Contains a discussion on the powerful anticancer effects of quercetin.

Etiology of Chronic Disease: A Discussion on Epstein-Barr Virus

Spotlight on CLA, a Cancer-Fighting Fatty Acid: CLA (Conjugated Linoleic Acid) is a fatty acid found in grass-fed meats and dairy products, but can also be taken in supplement form.  CLA suppresses the development of cancer at various levels. CLA has been shown to decrease skin, liver, and colon cancer. Activating protein-1 (AP-1) is one of the main promoters of colon and breast cancer, but it is blocked by CLA (licorice root and rosemary-fresh or essential oil also do this). Human abdominal, breast, and axillary fat have the ability to convert androgens into estrogens. Some studies show CLA helps rid the body of belly fat and may modulate immune and inflammatory responses.

To get an additional $30 off on the Online Course for Breast Cancer, Toxic Free Me, enroll now and use this LINK.

Additional Resources for this article:

In your good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

Follow Elyn on LinkedIn

[i] https://books.google.com/books?id=RIydBQAAQBAJ&pg=PA120&lpg=PA120&dq=dr+norman+farnsworth+pau+d%27arco&source=bl&ots=ZqFrjj9sQr&sig=

[ii] https://www.ncbi.nlm.nih.gov/pubmed/19578798; https://www.ncbi.nlm.nih.gov/pubmed/25891355

[iii] https://www.ncbi.nlm.nih.gov/pubmed/19578798

[iv]  http://www.ndhealthfacts.org/wiki/Phytoestrogen

[v] https://cancerres.aacrjournals.org/content/55/17/3712.short; https://www.ncbi.nlm.nih.gov/pubmed/27048660; http://www.ucdenver.edu/academics/colleges/pharmacy/currentstudents/OnCampusPharmDStudents/ExperientialProgram/Documents/nutr_monographs/Monograph-pau_darco.pdf

[vi] https://cancerres.aacrjournals.org/content/55/17/3712.short

[vii] https://www.ncbi.nlm.nih.gov/pubmed/27048660

[viii] https://www.ncbi.nlm.nih.gov/pubmed/27048660

New Online Course for Breast Cancer: Toxic Free Me

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, antioxidants, aromatase inhibitors, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, chemo and cancer stem cells, chemotherapy, colon cancer, Estrogen, Estrogen and Breast Cancer, foods that target cancer stem cells, Healing Cancer Naturally, High Dose Vitamin C, Hormone Balance, inflammation, Inflammatory Breast Cancer, Iodine, Mind Body Therapies for Cancer, Natural Alternatives to Aromatase Inhibitors, prostate cancer, Radiation, radiation and cancer stem cells, Tamoxifen, targeting cancer stem cells, trapped emotions and cancer stem cells, Uncategorized, what causes cancer to spread on October 28, 2019 at 9:22 am

As a holistic cancer coach (and survivor of stage 3 hormone-positive breast cancer), I work with people with many different types of cancer. However, the majority come to me looking to avoid the dreaded tamoxifen, aromatase inhibitors, Herceptin, Lupron, and other drugs and treatments, such as chemo and radiation. And of course, everyone is looking to get through cancer with the least amount of collateral damage and to do what they can to reduce the risk of recurrence or further cancers–to survive and live well. I coach one-on-one, but also offer a plethora of information on my website. However, some people are looking for options other than individual coaching or DIY (do-it-yourself) healing.

About a year ago I decided I would offer a webinar course to cover these topics and more. However, as life and work got very busy, I put that on hold. Meanwhile, my colleague and friend, Marnie Clark is now offering a fantastic ‘how-to-get-through-breast-cancer-course. Toxic Free Me is a comprehensive online-course with multiple learning modules.

The beauty of the course is that you can learn at your own pace. Plus, she will be adding to the course as new information comes out, and subscribers will have full access at no additional charge. The course is valued at $295 and offered for a limited time at $179, but if you enroll now and use this LINK, you get the entire course for only $149, with a 30-day money back guarantee.

Is this course for you? Are you determined to survive your cancer and live well? Are you looking for safe, non-toxic remedies for your cancer (alongside or without conventional treatments) that will support your body, build your immune system, and lower your risk of recurrence? Have a look at the full course description HERE.

Remember, when you enroll now and use this LINK, you get the entire course for only $149.

This information is for educational and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. The information provided is from my research and not to be taken as scientific evidence.

In your good health,

Elyn

~~If you don’t know your options, you don’t have any~~

Marnie_homepageMarnie Clark is a breast cancer coach, and also a 15-year breast cancer survivor. Marnie has studied natural medicine for over 25 years and knew that in order for her own body to heal from breast cancer, it would require a blend of both conventional and natural medicine. She now teaches others going through breast cancer about the things in nature that help to make the body hostile terrain for cancer cells, as well as empowering clients with knowledge about the lifestyle alterations that are crucial to the healing process. Marnie draws from several decades of experience in the disciplines of massage therapy, natural healing and nutrition, aromatherapy and energy healing. Her website is https://MarnieClark.com.

ej portrait 150res for PrueElyn Jacobs is a 12-year breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

 DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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Could Aromatase Inhibitors Actually Increase One’s Risk for Breast Cancer?

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, aromatase inhibitors, Breast Cancer, Cancer, Estrogen, Estrogen and Breast Cancer, Hormone Balance, Hot Flashes and Night Sweats, Soy and Breast Cancer Risk, Uncategorized on October 21, 2019 at 4:05 pm

Most oncologists recommend estrogen blockers or aromatase inhibitors for those with hormone-sensitive cancers. However, new research shows that decreased estrogen levels can promote insulin resistance, which may actually increase the risk of cancer of the breast, endometrium, and ovaries. 

To recap from my previous post, What You Need to Know About Sugar and Breast Cancer, insulin resistance leads to increased insulin in the body. High insulin triggers breast cancer cells to divide and grow.

After menopause many women face a dramatic increase in insulin resistance (and start noticing belly fat that wasn’t there before). Declining estrogen is considered to be the reason.[i] If decreased estrogen promotes insulin resistance, could intentionally reducing estrogen increase one’s risk of breast cancer? Can aromatase inhibitors actually promote breast cancer? Research shows they just might.

Decreased Estrogen Levels Promote Insulin Resistance

Studies (both clinical and animal) have shown a strong correlation between circulating estrogen deficiency and insulin resistance. At Texas A&M, a team lead by Dr. Shaodong Guo identified that decreased serum estrogen levels promote insulin resistance and that even a slight decrease in circulatory estrogen levels is associated with resistance and may increase the risk of cancer of the breast, endometrium, and ovaries. The researchers found that “for premenopausal women, even a slight decrease in their circulatory estrogen levels associated with insulin resistance may increase the risk for cancers, particularly in the organs having high estrogen demand (breast, endometrium and ovary). On the other hand, postmenopausal state with profound estrogen deficiency confers high risk for cancers in different organs with either high or moderate estrogen demand.”[ii]

According to the Guo, the lead investigator for the Texas A&M study, estrogen deficiency or impaired estrogen signaling is associated with insulin resistance. “Studies have shown the reduction of estrogen in postmenopausal women accelerates the development of insulin resistance and Type 2 diabetes.” He further explains that estrogen replacement therapy in postmenopausal women can reduce insulin resistance. “Clinical trials of estrogen replacement therapy in postmenopausal women have demonstrated a lowered insulin resistance as well as reductions in plasma glucose levels.”

2015 research published in the Journal or Diabetes Research also concluded that the loss of circulating estrogen E2 and impairment of its cellular activity can lead to an abrupt reduction in metabolic rate and that E2 replacement is preventive. “It is very clear that E2 has tremendous potential as a therapeutic against diabetes and its associated complications, but it has to be administered in a safer form and personalized to individual needs”. [iii]  While the link between synthetic HRT (hormone replacement therapy) and breast cancer has been established and therefore may not be an option, it  just doesn’t make sense to intentionally lower our own already-declining natural estrogen.

Many women choose bio-identical hormones, but to be clear, bios are not ‘natural’, they are chemically constructed in a lab. According to Dr Mache Seibel, M.D., author of The Estrogen Window, you have to be careful with compounded bio-identicals. He says that studies show that despite the fact that the prescription may be filled correctly, typically progesterone tends to be 60-80% lower than ordered and estrogen 80-200% higher than ordered which can result in increased estrogen dominance and could raise your risk of hormone-driven cancer. He also points out the serious risks of declining estrogen, which include increasing your risk of heart disease by 30% and dementia 70%. 

Why You Need Estrogen 

We need estrogen for aiding in the prevention of heart disease and for strong, healthy bones. In fact, estrogen is essential to the health of all parts of your body, from your eyes to your heart to your brain to everywhere else.  Estrogen also improves body fat distribution and B-cell function, and reduces inflammation. And of course, estrogen increases insulin sensitivity (and thus is protective against diabetes and metabolic syndrome predisposing one to obesity) and conversely, low estrogen levels can lead to increased insulin resistance or impaired insulin activity.

Given that studies show that the reduction of estrogen in postmenopausal women accelerates the development of insulin resistance and thus could promote breast cancer, it is hard to believe that aromatase inhibitors are always a good idea. Perhaps ‘prescribing’ phytoestrogens such as flax and sesame seeds, herbs, and even perhaps whole soy, would be a better tactic. Phytoestrogens are plant-based weak estrogens which bind to estrogen receptors in the body (just like tamoxifen) and through competitive inhibition, can prevent the receptor-binding of more potent estrogens (including xenoestrogen such as BPA). Phytoestrogens also promote hormone balance and homeostasis. One can also take steps to raise progesterone to balance natural estrogens by taking supplements such as zinc and vitamin E, lowering stress, and using an over-the-counter progesterone cream. I will further address the role of phytoestrogens and hormone-driven cancers in my next post.

Natural Aromatase Inhibitors

Some natural substances and formulas that reduce aromatase activity (should you need to reduce aromatase activity or improve estrogen metabolism or hormone balance) include Calcium d Glucarate, which helps clear excess estrogen and chemical estrogens from the body, and a product known as Aromastat, which contains a blend of herbal ingredients that work together to help keep your natural hormones balanced.  Aromastat contains chamomile (apigenin), chrystin, daidzein, genistein, indole-3-carbinol, and glycitein (it does contain soy isolates, so if avoiding, look for these ingredients individually, although in the case of genistein, I prefer you eat organic whole soy). For more information on natural alternatives to tamoxifen and aromatase inhibitors, please read my previous posts on the subject or visit my Shop page.

This information is for educational and thought-provoking purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. The information provided is from my research and not to be taken as scientific evidence.

In your good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150resElyn Jacobs is a holistic cancer strategist and speaker specializing in the prevention and treatment of cancer. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/#B135-ijms-18-01381

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

https://www.ncbi.nlm.nih.gov/pubmed/28396216

https://www.hindawi.com/journals/jdr/2015/916585/

https://www.ncbi.nlm.nih.gov/pubmed/30487265

https://diabetes.diabetesjournals.org/content/68/2/291

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

Follow Elyn on LinkedIn