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Cancer Coach Elyn Jacobs, cancer stem cells and metastases, chemo and radiation cancer stem cells, Holistic Cancer Treatment, Natural Alternatives to Aromatase Inhibitors, natural alternatives to Tamoxifen, Radiation Therapy Risks

Why You Might Want to Think Twice About Radiotherapy for Cancer

In Alternative Cancer Therapies, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer diet, Breast Cancer, Cancer Coach, chemotherapy, Integrative Oncology, Natural Aromatase Inhibitors, Radiotherapy for breast cancer, Uncategorized on January 24, 2023 at 2:19 pm

“Elyn, we could do lumpectomy with radiotherapy, but did you know that radiation can result in more cancer?” These were the words the first surgeon I went to see uttered during my consult (February 2007). Stunned, I told him I would not do it. He then explained that lumpectomy wasn’t really an option considering how much cancer was in my left breast and therefore made no sense to do lumpectomy and harmful radiation. But his words of warning will never be forgotten. I chose mastectomy, but with a different surgeon who also said mastectomy was the best choice (I just felt more comfortable with him and his associated hospital).

The question one needs to ponder is why would any doctor push a cancer-promoting therapy on a person with cancer? We all know that radiation is linked to cancer, and we all know that potentially and intentionally inflicting up to 3^rd degree burns cannot be a good thing! (Read on to understand more on the harms and limitations of radiotherapy as well as chemotherapy.)

When I was diagnosed again in 2014 for stage 3 lymph node involvement, this time I was offered radiation and chemo. I declined both. My oncologist was relieved that I was declining the radiation. He suggested the chemo and when I declined, he offered low-dose chemo. I declined that too, which he was fine with. He had done his job of recommending the standard of care and backed it up with a letter to my surgeon stating I flat out refused. I embarked on a holistic protocol, which he fully supported.

So Why do Docs Recommend Radiation?

What you need to know too is that doctors and other medical professionals can lose their license to practice medicine if they fail to recommend anything other than the standard of care, meaning conventional cancer therapies such as chemo and radiation. These therapies are also part of their very limited toolbox as holistic therapies are typically not taught in medical school.

Sadly, radiation therapy is a huge profession (same for other cancer treatments), one that enthusiastic young medical students flock to. It’s what they are then trained to do and fall under the belief that they are doing good.

True, it is believed that radiotherapy that has the potential to reduce the risk of recurrence in the local area (not always but sometimes). However, no one dies of a local breast tumor, for example. And radiotherapy does nothing for the cancer stem cells, the only cancer cells that can metastasize (“mets”) to other areas such as the lungs, brain, and bones. Metastasis essentially shuts down essential organs and body systems (such as digestion, bones, lungs, liver, brain, etc.), resulting in death.[i] (Of course, the ‘treatment’ for mets is often chemotherapy, which also doesn’t target stem cells and is highly toxic to essential organs, again often resulting in death, particularly when given repeatedly).

But what these professionals do not tell you is that “Cancer stem cells (CSCs) comprise the subpopulation of tumor bulk and acquire resistant to conventional therapies and are considered as the primary tumor initiator cells. Nowadays, the tumor heterogeneity originated from CSCs, and its progenitors are accepted as a mortifying drawback in front of the cancer therapies.”[ii] Let that sink in. In layman terms, it means that CSCs are the reason that conventional treatments fail and encourage progression of the disease.

To learn more about cancer stem cells and what you can do about them, please read Cancer Stem Cells and Progression of Disease: What You Need to Know Now. In the article is a link to a second article and to a podcast of mine.

Other Risks of Radiotherapy:

Radiation increases the risk of skin cancer in the treatment area.
Radiation to lymph nodes can cause damage to lymph nodes and lead to lymphedema.
Radiation treatment to the chest can affect the heart. You may be at a higher risk of cardiac (heart) issues if your breast cancer was in the left breast. Speak to your radiologist for breathing techniques that mitigate this risk.
Radiation can cause small cracks (fractures) in the bones that are in the treatment field.
Radiation to the chest or underarm area can experience damage to the brachial plexus nerve.
Radiation injury to the nerves and muscles is called radiation-induced neuropathy or radiation fibrosis. It tends to develop in the years following treatment and slowly worsens over time [i]

If you are considering radiation (or chemo), I strongly suggest you do your research first. And always work with an integrative professional or coach if you do choose these treatments. If you have had radiotherapy or chemo, I strongly suggest you move on and embrace the fact that you made the best choice you could at the time and meanwhile work on targeting the stem cells as well as the reasons for the original cancer.

To learn more about holistic remedies for cancer, please visit my website.

For Supplement information and brand recommendations, please visit my supplement page HERE.

Always remember that you and only you can determine the best treatment for your cancer. Your cancer, your body, your choice of treatment.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment. This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice, nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence. Elyn Jacobs Consulting, Inc. does not provide endorsement for the content, claims, or products discussed in this article.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part using affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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[i] https://www.emedicinehealth.com/how_does_metastasis_cause_death/article_em.htm

[ii] https://pubmed.ncbi.nlm.nih.gov/30268439/

But what these professionals do not tell you is that “Cancer stem cells (CSCs) comprise the subpopulation of tumor bulk and acquire resistant to conventional therapies and are considered as the primary tumor initiator cells. Nowadays, the tumor heterogeneity originated from CSCs, and its progenitors are accepted as a mortifying drawback in front of the…

Alternative Cancer Therapies, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer diet, Breast Cancer, Cancer Coach, chemotherapy, Integrative Oncology, Natural Aromatase Inhibitors, Radiotherapy for breast cancer, Uncategorized

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best diet for fatty liver, Declining estrogen and fatty liver, estrogen and cardiovascular health, Fatty Liver and Estrogen, Fructose and liver health, high protein diet for liver health, milk thistle for fatty liver, reversing fatty liver disease, Why you shouldn't take aromatase inhibitors

Estrogen and Your Liver: What you Need to Know About Declining Estrogen and NAFLD

In Alternatives to Anti-Hormone Therapy For Breast Cancer, antioxidants, aromatase inhibitors, Bio-Identical Hormones, Breast Cancer, Cancer, Cancer Coach, Estrogen, Estrogen and Breast Cancer, Hot Flashes and Night Sweats, inflammation, Integrative Oncology, menopause, NAFLD and Estrogen, Natural Alternatives to Aromatase Inhibitors, Natural Aromatase Inhibitors, Uncategorized on May 16, 2022 at 9:03 am

Estrogen plays a key role in our body. It is involved in everything from prepping for reproduction to keeping bones strong and eyes healthy. It improves insulin sensitivity and facilitates the export of lipids from the liver. It protects the heart and modulates cholesterol. Estrogen controls everything from the smoothness of your skin to where your body stores fat. Declining estrogen is driving an epidemic of fatty liver among postmenopausal women.

Reduced Estrogen and Your Liver

Many women are all too aware that declining estrogen levels result in hot flashes, mood swings, thinning of the hair, osteoporosis, and weight gain. But when estrogen drops, there’s no longer enough of it to steer where your fat goes-and so the fat goes where the body can most easily store it — the liver. This is turn antagonizes the metabolic and inflammatory alterations that trigger and boost a harmful condition called non-alcoholic fatty liver disease (NAFLD).

Early-stage NAFLD does not usually cause any harm, but it can lead to serious liver damage, including cirrhosis. Having high levels of fat in your liver is also associated with an increased risk of other serious health problems, such as diabetes, high blood pressure, and kidney disease.

Researchers at the University of Vermont found that decreasing estrogen levels are associated with an 82% increase in fat stored in the liver and other organs.[i]

By the age of 40, up to 90% of women are battling a fat-clogged liver, and post-menopausal women are developing NAFLD 60% faster than men of the same age.[ii] The buildup of fat in the liver also often leads to a pileup on pounds on the waist, hips, and thighs. Elevated ALT and AST on lab reports may be indicative of a fatty liver, especially if ALT is significantly higher than AST.

Lack of estrogen is associated with increases in cellular toxicity in the presence of abnormal fat accumulation, which can result in cell death, pro-inflammatory cytokines, and oxidative stress, and with decreases in anti-inflammatory cytokines.[iii]

It is becoming increasingly clear that once women reach menopause, they are exposed to increasing risks of developing complications due to a decrease in estrogen-related protective effects. Among the numerous protective effects of estrogen, preventing liver fat accumulation is important due to its role in the development of insulin resistance, atherosclerosis, and cardiovascular diseases.[iv]

“It’s never too late to turn the tide and eliminate liver fat”, Fred Pescatore, M.D.

What you can do NOW!

Cut down on fats and Fructose Results from animal studies indicate that high dietary fat (including nut butters and tahini) or fructose (eat fruit, skip fruit juice and certainly no high fructose corn syrup) intake can synergistically enhance the effects of estrogen deficiency, leading to exaggerated effects on liver injury and fat accumulation.[v]

Over the past century, the increased intake of added sugars (fructose in particular) is associated with increased incidence and progression of NAFLD and liver inflammation. Fructose enhances liver cell destruction, macrophage accumulation, and progression of fibrosis, all negative effects that can be reverted by estrogen supplementation. While bioidentical estrogens may not be a good option for many women (and synthetic estrogen is never a good idea), intentionally inhibiting estrogen may not make sense.

Lose weight and exercise. The rising trends in obesity has been linked with the increase in the incidence and severity of NAFLD. Currently, 74% of Americans over the age of 20 are either overweight or obese. In Europe the number is 60%, with 30% among children (up from 61% and 50% respectfully) Normal-weight postmenopausal women with lipid and glucose and insulin levels within normal range are at a lower risk of developing NAFLD.

Therefore, efforts to emphasize healthy diet and regular physical activity should be especially emphasized in middle-aged women as they approach menopause to prevent the development of NAFLD. Exercise seems to exert an estrogenic-like effect not only on expression of genes involved in lipid accumulation but also on expression of genes of inflammation in the liver.[vi]

Eat more protein. It is important to get sufficient protein, something we need more of as we age. A high protein (lower carb) diet can help switch off the genes responsible for storing fat in the liver (but not necessarily the Keto diet which is often too restrictive for optimal health and may include harmful processed meats such as bacon). Researchers reporting in the journal Liver International found that eating a high-protein diet cuts liver fat in half (a low-protein diet didn’t change liver fat).

Another study found that the genes responsible for liver-fat storage were less active in high protein dieters. “Amino acids are the building blocks of all proteins and boosting your intake of amino acids has been shown to help speed metabolism and fat burning,” explains Dr. Fred Pescatore in Fit for Women magazine.[vii] Animal-based proteins contain something calling branched-chain amino acids (BCAAs), which appear to be the most crucial to both weight loss and eliminating liver fat. More specifically, the branched-chain amino acid leucine, for example, instructs the body to burn the deep visceral fat that collects in the liver, while valine helps remove toxins from the liver. This lightens the load on the liver so it can focus on eliminating fat buildup. Studies show that following a high-protein diet for just two weeks can dramatically reduce liver fat. Protein also keeps you full longer so it may help with weight loss or management.

While the basic recommendation is to load up on protein, variety is helpful. While plant-based proteins are fine for most people, animal proteins contain all the BCAAs that are most crucial to eliminating liver fat (and encouraging weight loss). Wild-caught fish is a great option, alternating with grass-fed meats. You can even change up the amino acid profile by eating different types of fish and different cuts of meat. Full fat dairy is another option as it has a high concentration of BCAAs. Full-fat dairy is also rich in carnitine, which helps the body convert fat into energy, helping to eliminating liver fat (all dairy products should be organic and from pastured animals, never conventionally processed). The more carnitine, the more quickly fat gets burned.

Eggs, while controversial, are an excellent source of choline, a B vitamin that heals and energizes liver cells. Choline may help reduce your risk of fatty liver disease and interferes with progression. Choline deficiency is associated with liver dysfunction.[viii] (Choline is also found in meat, poultry, fish, dairy, cruciferous vegetables, and potatoes.)

While many studies show a beneficial role exerted by high-protein diets in reducing body weight and in reverting fatty liver disease, other studies suggest that high-protein diets can instead promote the development of NAFLD. Hence, don’t go overboard on protein—balance it out with a lot of vegetables and some fruits. Even too much of a good thing is not good and excess protein not a good idea for other reasons.

Eat your vegetables. For copious reasons, vegetable should be eaten throughout the day. They provide phytochemicals that keep inflammation in check so the liver can function optimally. Cruciferous veggies are particularly helpful as they are rich in indole, which helps break down liver fat. Also helpful are avocados, coconut, dandelion greens, mushrooms, okra, and squashes.

Get some sun. Unprotected sun exposure can also be helpful (no sunscreen) as UV light prompts the skin to make vitamin D, which switches on the liver enzymes that burn trapped fats for fuel. Get more sunshine or take vitamin D3.

Cut back on carbs. This is key to preventing future fat build up in your liver.

Supplement with Milk Thistle. Milk Thistle has been found to spur the growth of new liver cells damaged by fat buildup. The remarkable silymarin in it increases the body’s levels of liver detox enzymes dramatically. Studies confirm that milk thistle can protect liver function, prevent liver damage, and normalize elevated liver enzyme levels. Like silymarin, vitamins A, C, and E act like an antioxidant and support the live- just be sure not to take too much vitamin A.

Breast Cancer and Aromatase Inhibitors

This begs the question as to why oncologists are so bent on further reducing estrogen in postmenopausal women with hormone-sensitive breast cancers. This issue is indicative of many medical professionals. In my opinion, the goal should be to concentrate on estrogen metabolism and not reduction. Thus, it is up to you, the person whose goal is to keep the entire body healthy, and to make choices that best fit your needs. Taking hormone-blocking drugs is a choice, but any decision made from fear is likely not a good one. Please do your own research so there are no regrets.

To learn how to better manage hormones if you are in a cancerous state or have healed from hormone-related cancers, please visit my website or read my article Natural Alternatives to Anti-Hormone Therapies for Breast Cancer: What Your Doctor May Know but Cannot Recommend. To learn more about detoxification and estrogen, please visit my webpage on that.

Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

Excerpted in Part from First for Women Magazine

[i] https://www.pressreader.com/usa/first-for-women/20210607/281539408793660

[ii] https://www.pressreader.com/usa/first-for-women/20210607/281539408793660

[iii] https://www.frontiersin.org/articles/10.3389/fendo.2020.572490/full

[iv] https://www.hindawi.com/journals/jnme/2012/914938/

[v] https://pubmed.ncbi.nlm.nih.gov/29751074/

[vi] https://www.hindawi.com/journals/jnme/2012/914938/

[vii] https://www.pressreader.com/usa/first-for-women/20210607/281539408793660

[viii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/; https://my.clevelandclinic.org/health/drugs/22202-choline-supplement

Progesterone and Breast Cancer

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer diet, Anticancer foods, foods for colon cancer, foods for breast cancer, aromatase inhibitors, Bio-Identical Hormones, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, Estrogen, Estrogen and Breast Cancer, Healing Cancer Naturally, Hormone Balance, infertility, insomnia, Integrative Oncology, Natural Alternatives to Aromatase Inhibitors, Natural Aromatase Inhibitors, Tamoxifen, Uncategorized on January 29, 2022 at 12:59 pm

Progesterone is vital to the female body, yet many women fear it. Progesterone is the key to many aspects of female health, and often thought of as one of the most important hormones. But most women have very low levels of progesterone which can result in estrogen dominance and can significantly increase one’s risk of breast cancer!

In short, estrogen and progesterone work in tandem. The former hormone helps cancerous cells flourish while the latter puts the brakes on cell growth and proliferation.

Why You NEED Progesterone

Progesterone is the precursor to other important hormones, including estrogen and testosterone. These hormones play a significant role in female health, influencing everything from cognitive function, menopause, fertility, helping the uterus to grow during pregnancy, normal breast development during puberty, and so much more, including breast cancer prevention. Importantly, the body depends on the right balance of these hormones in order to function properly.

“Estrogen can cause cells to grow or proliferate, but progesterone decreases proliferation/cell growth while encouraging cells to become more specialized or mature, so in effect, progesterone’s actions decrease cancer risk. When progesterone is present, its receptors make the estrogen receptor no longer able to cause breast cells to grow or proliferate.”[i] (The Centre for Menstrual Cycle and Ovulation Research). More on receptors below.

Natural progesterone is not to be feared. In fact, it is widely believed that estrogen can only fuel breast cancer in the absence of progesterone. In essence, progesterone puts the brakes on cell proliferation and growth. Estrogen should also not be feared and is actually essential for so many reasons (heart, bone, and eye health, etc.) The Important thing is to help your body metabolize estrogen properly so the body can use what it needs and excrete the excess ( a topic beyond the scope of this article).

The confusion about progesterone comes from studies using progestin (synthetic progesterone). Progestins are NOT the same thing as progesterone. But again, one of progesterone’s jobs is to decrease the risk for breast cancer. It does that by decreasing the proliferation often caused by excess estrogen.

Importantly, chemical estrogens (also known as xenoestrogens) such as BPA (bisphenol A) and other chemicals often found in home and personal care items are another story. They DO fuel breast cancer. For more information on the damages of BPA and BPS please read: BPA: The Bathroom Toxin that Fuels Breast Cancer.

Symptoms of Progesterone Deficiency Include:

Unexplained fatigue and low energy
Intense PMS symptoms such as cramps and moodiness
Dizziness
Difficultly sleeping
Irritability
Ovarian cysts
Fibrocystic breasts
Mood swings
Hot flashes
Low libido
Irregular menstrual cycles
Weight gain
Fibroids
Endometriosis
Thyroid dysfunction
Infertility and miscarriage
Uterine bleeding
Breast and other cancers

Some women have been progesterone-deficient most of their lives, whereas others find themselves in this predicament around age 45 or so, when the ovaries stop making the hormones estrogen and progesterone and turn the job over to the adrenals. Regardless, it is imperative that we increase progesterone if it is low and in turn, balance the hormones. Clearly the list above gives you enough reasons.

Raising Progesterone

Foods that can help raise progesterone include broccoli and other cruciferous vegetables, beans, and nuts. Supplements include magnesium, and vitamin E (mixed tocopherols). Chaste Tree (Vitex) can also stimulate progesterone. Activated B6 is necessary for the synthesis of progesterone and helps the liver to metabolize and break down estrogen (B6 can also available in food sources such as leafy greens, peppers, carrots, asparagus, broccoli, walnuts, eggs, sweet potatoes, and sunflower seeds. For the carnivores, you can find it in grass-fed beef and beef liver). Zinc supports the production and use of progesterone. A deficiency in zinc increases estrogen sensitivity and decreases the progesterone response.

Things that deplete progesterone are stress and excessive exercise (which cause the body to produce stress hormones instead of progesterone).

Importantly, too much zinc will deplete copper. While copper can promote cancer, the body does need just a bit. Cooper deficiency can cause extreme tiredness, elevated cholesterol, brittle bones, increase risk of infection, and more.

A Note About Bio-Identical Progesterone

It is important to understand the difference between progesterone that is made by the body or is molecularly similar to one’s own natural progesterone and synthetic progesterone, which has been molecularly altered. This is why many women opt for bio-identical progesterone.

However, as discussed in a previous article, Could Aromatase Inhibitors Actually Increase One’s Risk for Breast Cancer prescription bio-identicals can be problematic. According to Dr Mache Seibel, M.D., author of The Estrogen Window, you must be careful with compounded bio-identicals. This is because sometimes the progesterone in compounded formulas can be 60-80% lower than ordered and estrogen 80-200% higher than ordered which can result in increased estrogen dominance. This could raise your risk of hormone-driven cancer.

Another option is bio-identical topical creams. There are a few good ones on the market, but one I use is Progesto-life. According to the instructions, you just rub a quarter teaspoon into your wrist or belly.

I strongly suggest you work with a qualified practitioner before beginning any type of bio-identical hormones. There is much we don’t know and some react differently than others. Please know that your oncologist might not be trained to discuss this with you.

Importantly, please do not confuse hormone levels with receptor status!

Hormones are your body’s chemical messengers. They travel in your bloodstream to tissues or organs to help them do their work.

Estrogen and progesterone receptors are proteins in cells that bind hormones and switch genes on and off, changing the cell’s behavior. Hormone receptor-positive breast cancers have many receptors, and the tumor cells become overly sensitive to estrogen. When estrogen activates the estrogen receptor, it signals the genes that tell the cells to keep dividing, driving tumor growth. However, when breast cancer cells have working progesterone receptors, and there is sufficient progesterone available, progesterone will slow down estrogen fueled growth and division of these cells.

The late John Lee, MD, author of What Your Doctor May Not Tell You About Breast Cancer maintained that when activated by progesterone, its receptors attach themselves to estrogen receptors. This tells the genes that promote growth to pivot and instead promote the death of cancer cells.

A study published in the Dec 2016 edition of the journal Nature, led by Cambridge-based Cancer Research U.K. researcher Dr. Jason Carroll of the University of Adelaide in Australia found that progesterone –via the progesterone receptor– reprograms the estrogen receptor, causing the cells to stop growing as quickly. For more information, please read my article, Progesterone and Breast Cancer.

So, if you are ER and or PR positive it simply means you have receptors for these hormones. It does not mean you have high levels of either hormone. In fact, most doctors recommend tamoxifen or aromatase inhibitors without even testing hormone levels, which could be a big mistake (particularly in the case of aromatase inhibitors).

For those who have or have had TNBC (triple negative breast cancer), progesterone has been found to inhibit this type of cancer as well.

This article is a re-write from a previous article of mine published in January 2020.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment. This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

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[i] https://www.cemcor.ca/resources/does-taking-progesterone-alone-or-estrogen-increase-women%E2%80%99s-risk-breast-cancer

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balancing hormones naturally, DIM and Breast Cancer, Estrogen and Breast Cancer, Flaxseed and Breast Cancer, Flaxseed and Estrogen, herbs for hormone balance, Natural Alternatives to Aromatase Inhibitors, Natural Alternatives to Tamoxifen and Aromatase Inhibitors, Natural Cancer Therapies, phytoestrogens and breast cancer, probiotics and breast cancer, progesterone and breast cancer, soy and breast cancer, vitamin e and progesterone

Natural Ways to Balance and Manage Hormones for Breast Cancer

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer diet, Anticancer foods, foods for colon cancer, foods for breast cancer, aromatase inhibitors, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, Estrogen, Estrogen and Breast Cancer, Hormone Balance, Integrative Oncology, Natural Alternatives to Aromatase Inhibitors, Natural Aromatase Inhibitors, Uncategorized on August 4, 2020 at 7:17 am

Hormone imbalances occur when we have to much or too little of a hormone in your bloodstream. While your body secretes about 50 different hormones that control many critical functions, for the purpose of this article, I will be discussing only estrogen and progesterone. When estrogen is high and progesterone is low, we have a condition known as estrogen dominance. Estrogen dominance is often a strong risk factor for breast cancer. Fortunately, there are many natural ways to balance the hormones and manage risk of cancer.

Even small hormonal imbalances can create side effects, including increased risk of breast cancer. What women with breast cancer hear most from their doctors is that estrogen is the villain, the cause of our cancer. However, while estrogen can fuel breast cancer, there is more to the story. Estrogen can fuel a tumor’s growth, but progesterone may put the brakes on that growth.

To be clear, estrogen is not bad, and in many cases, should not be reduced without due care. Estrogen plays a major role in numerous processes including blood sugar balance, as well as bone, eye, and heart health. But it needs to be balanced by progesterone, something that drops dramatically with age and increased stress.

To recap an article I wrote for The Truth About Cancer, estrogen and progesterone receptors are proteins found within many of the cells of our bodies, including cells in the breasts. Both receptors are directly involved in switching genes on and off − some 470 different genes. When estrogen and progesterone are present, these hormones stick to their respective receptors. They can then attach to specific regions of our DNA and turn genes on or off, changing the cell’s behavior.

Hormone receptor-positive breast cancers have many hormone receptors. In the case of breast cancer, tumor cells become overly sensitive to estrogen. When estrogen activates its receptor, it turns on a panel of genes that tell cells to keep dividing, encouraging tumor growth. However, the body also has progesterone receptors. When breast cancer cells have working progesterone receptors, and when there is sufficient progesterone available, progesterone will slow down estrogen-fueled growth and division of these cells. According to the late John Lee, Md, author of What Your Doctor May Not Tell You About Breast Cancer, when progesterone receptors are activated by progesterone, they attach themselves to the estrogen receptors. This essentially puts the brakes on the estrogen receptors, telling them to stop turning on genes that promote the growth of cancer cells, and turning on genes that promote the death of these cells.

A 2016 study led by Cambridge-based Cancer Researcher Dr. Jason Caroll of the University of Adelaide in Australia found that progesterone, via the progesterone receptor, is affecting how the estrogen receptor works. He found that the progesterone receptor actually ‘reprograms’ the estrogen receptor, changing the genes that it influences.[i]

Importantly, Carroll found that progesterone seems to cause cancer cells to stop growing as quickly. That said, what I am referring to is natural progesterone. While natural progesterone has an anticancer effect, synthetic progesterone does not and can actually make cancers more aggressive and deadlier. Further, synthetic progesterone does not activate tumor suppressor gene p53 when it attaches to progesterone receptors. P53 is a repair gene, which protects cells from becoming cancerous.

Toxic Substances Act Like Estrogen

We are bombarded daily with chemicals in the air, our food, and the products we use in our home and on our bodies. These chemicals, also known as xenoestrogens, are considered endocrine or hormone disruptors because they interfere with the production of hormones. They cause wide-ranging damage in the body. For example, bisphenol A (BPA) and bisphenol S (BPS), found in plastics, can liners, cash register receipts and most paper products mimic estrogen and can disrupt multiple hormonal pathways. Unlike our own estrogen, chemical estrogens (xenoestrogens) are particularly harmful. Read more HERE.

Fortunately, there are many natural approaches to ease hormones back into balance and reduce your risk of breast cancer.

Natural Approaches for Balancing Hormones

Let’s take a look at some herbs and natural approaches to balancing hormones.

Phytoestrogens modulate estrogen levels. Phytoestrogens work similarly to tamoxifen, blocking the effects of estrogen in breast tissue.[ii]

They act more like estrogen blockers than like estrogen; they modulate the production, availability, and action of hormones and slow down cell division. This is important as many oncologists illogically warn women to avoid them.

Phytoestrogens bind preferentially to estrogen receptor sites in the body. However, they are 99% weaker than our own natural estrogen, which means that they have very little estrogenic effects in the body. It also means that by binding to the receptors, more aggressive natural estrogen or xenoestrogens from the environment will be less able to bind to the receptors. Therefore, phytoestrogens might limit the negative estrogenic impact of those estrogens. Instead of fueling estrogen-dependent cancers, phytoestrogens tend to reduce the risk of these cancers. Even the NCI (National Cancer Institute) acknowledges that the plant-based hormones may have anticancer effects.[iii]

Meanwhile, if you are post-menopausal with very low estrogen levels, phytoestrogens may help reduce the resulting effects, such as bone loss, eye damage, and heart damage. Soy and flaxseed are two of the most powerful phytoestrogens, but herbs such as red clover, sage, hops, and fenugreek are also helpful.

Soy blocks cancer-promoting estrogens from attaching to the estrogen receptors on breast cells. It has also been shown to stop tumor growth, prevent metastasis, and shut off new blood vessels in growing tumors. Fermented soy, such as tempeh and miso are preferred over unfermented versions such as tofu. This is because the fermentation process increases free radical scavenging activity and removes the nutrient blocking effect that soy can have—the phytic acid in unfermented soy can block absorption of key minerals such as magnesium and zinc. Soy in a highly processed form (like soy protein isolate or soy protein concentrate) should be avoided as they have the greatest ability to block nutrient absorption. Due to the fact that most soy is genetically altered, it is highly recommended to consume only organic and non-GMO. (My only issue with tempeh is that it is commonly ‘shrink-wrapped’ in plastic’)

Flaxseed modulates the production, availability, and action of hormones—and does so much more (flax –and sesame seeds– offer anti-cancer lignans which can significantly reduce tumor growth by increasing cell death and decreasing the growth of new blood vessels that allow cancer to advance). As for hormones, the lignans in flax lower the production of estrogen by blocking the aromatase enzyme (similar to aromatase inhibitors) and block the estrogen receptors (similar to Tamoxifen). When lignans are consumed, intestinal bacteria convert them into enterolactone and enterodiol, weak estrogens. They attach to estrogen receptors, stimulate them weakly and block estrogen binding. This prevents estradiol or estrone from attaching to the estrogen receptors and strongly stimulating them, and includes not just the estrogen we produce, but also environmental toxins, thus making breast tissue more resistant to these environmental toxins. One long-term study reported that relatively high circulating enterolactone levels are associated with lower risk of death after an early-stage breast cancer diagnosis. Please read my articles — Flaxseed: Better Than Tamoxifen and Demystifying Flaxseed and Estrogen.

Licorice root and Vitex (also known a chaste tree berry), focus more on raising progesterone. Progesterone tends to fall sharply as we age and are no longer ovulating. While bio-identical progesterone supplement progesterone directly, licorice root and vitex are thought to lower estrogen levels while simultaneously raising progesterone, thus helping to relieve hormone imbalance and estrogen dominance. (use caution if you have elevated blood pressure)

Combining vitex with stress-reducing adaptogens such as ashwagandha or Schisandra can be helpful as stress tends to lower progesterone. Some people have reported that vitex worsens depression, so discontinue if that happens. (Do not take Schisandra with Tamoxifen).

Red clover can bind weakly to estrogen receptors, standing in for estrogen when levels are low and lowering high estrogen levels, helping to balance the hormones and correct estrogen dominance.

White peony root, something often used in traditional Chinese medicine, also supports progesterone. Black cohosh seems to support healthy estrogen levels not by actually boosting estrogen, but by improving brain-ovary communication and modulating cell receptors. This can help reduces menopausal symptoms and ease depression.

Adaptogens such as maca support hormone balance and may boost libido and mood while decreasing anxiety.

Vitamin E is crucial to maintaining a healthy balance between progesterone and estradiol. Vitamin C plays an important role in preventing the degradation of steroid hormones into toxic and cancer-promoting metabolites. It also regenerates estrone and significantly regenerates progesterone.

Vitamin B6 has been shown to help increase levels of progesterone in the blood naturally. Magnesium is another key nutrient for increasing progesterone levels, as it plays an important role in maintaining a healthy hormonal balance in the body.

Probiotics support gut bacteria and improve digestion, helping to prevent constipation. This is important because when poop remains in the bowel for extended periods of time, excess estrogen is re-absorbed and re-circulated into the bloodstream. Plus, immune function depends on healthy gut microflora—and gut flora effects cancer genes too!

Consume GLA (gamma-linoleic acid), which is found in evening primrose oil and in hemp seeds. Research shows that this type of omega-6 may support healthy progesterone levels.

Get more sleep—lack of sleep disturbs hormone balance. Try to get to sleep by 10 pm as melatonin production peaks between 10 pm and 2 am. Melatonin stimulates tumor-suppressor genes and counteracts the effects of aggressive estrogens, including xenoestrogens. Cell phone EMF exposure can suppress the production of melatonin—limit use before bed and do not keep near your bed, and preferably out of your room.

If you are overweight, lose weight. Fat cells increase estrogen production. Increased weight often means insulin resistance and this is a common cause of high estrogen levels. Insulin resistance leads to an up regulation of the aromatase enzyme leading to high estrogen. Plus, over-consumption of calories leads excessive free radical formation. Free radicals damage cells and cause genetic mutations, which ultimately can lead to cancer.

Your Liver and Estrogen

Be sure that your liver and gut are functionally efficiently as estrogen is metabolized in the liver and excreted out of the bowel. Think of your liver as a filter that neutralizes toxic substances so that they can safely be excreted from the body. By enhancing liver function, more estrogen is broken down in the body, reducing the overall estrogen load.

When the liver and colon have become sluggish due to low thyroid function, stress, and an overburden of toxins, the body cannot break down and remove excess estrogen adequately from the system. The excess unbalanced estrogen gets stored in the fat cells of breast tissues when it is not properly eliminated. Nutrients derived from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts as well as sulforaphane supplements help with the detoxification of estrogen through the liver (Read about Sulforaphane HERE)

Supporting the liver with supplements such as N-acetylcysteine (NAC), Milk Thistle, and SAMe can be very helpful. DIM and Indole-3Carbinol, two other extracts of cruciferous vegetables, can encourage proper metabolism of estrogens in the body and help to clear excesses and xenoestrogens from the system. Dandelion, herbal bitters, artichoke extract, also support the liver in detoxifying, metabolizing, and excreting hormones. Fiber binds to bile (liver’s waste) to support excretion.

For more on detoxification and liver function, please request my Estrogen and Detoxification Handouts or visit the Estrogen Management and Detoxification Sections on my supplement page.

Natural Aromatase Inhibitors:

Pumpkin seeds, button mushrooms, and supplements such as DIM, vitamin K2, calcium d-glucarate, zinc, gingko biloba, and grapeseed extract (organic please) are natural aromatase inhibitors. Research done at the State University of New Jersey demonstrated that a 2% concentration of rosemary extract was able to inactivate excess estrogen[iv] Apigenin – found in parsley, celery, and chamomile—is another aromatase inhibitor and is a potent estrogen metabolizing compound.

Read more on Natural Aromatase Inhibitors HERE.

Note: while herbs are powerful, it may take at least 4 months of use to begin to show benefits. Further, herbs can interact with one another or with various medications, so always consult your doctor before use.

Testing: If you are looking to lower your estrogen levels, you may want to test your hormone levels first. You can be low on estrogen and still be estrogen dominant, so it may be important to acquire this information. Also note that it is possible to have ‘normal’ estrogen levels when tested via blood or saliva, but still have high estrogen symptoms. This can happen if your body is not detoxifying estrogen correctly.

Estrogen Dominance Saliva Test for Hormone Balance – 2 Tests

Female/Male Saliva Profile I – Test Kit For 5 Hormone Level Imbalances

Female/Male Saliva Profile III – Test Kit For 8 Hormone Level Imbalances

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit http://www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment. This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

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[i] http://scienceblog.cancerresearchuk.org/2015/07/08/solving-a-breast-cancer-mystery-why-do-double-positive-women-do-better/

[ii] . https://marylandoncology.com/disease-drug-info/glossary/P/P1080/

[iii] https://marylandoncology.com/disease-drug-info/glossary/P/P1080/

[iv] https://pubmed.ncbi.nlm.nih.gov/9806165/

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broccoli and cancer stem cells, broccoli sprounts and sulforaphane, cancer stem cells, COVID-19, DIM, Elyn Jacobs, Glutathione and Cancer, growing your own sprouts, Hamama sprout kits, health benefits of broccoli sprouts, indole 3 Carbinol, lutein and cancer, sulforaphane and cancer, watercress

Broccoli and Watercress Sprouts Fight Cancer

In Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer diet, Anticancer foods, foods for colon cancer, foods for breast cancer, antioxidants, aromatase inhibitors, Books for Cancer Patients, Breast Cancer, Cancer, Cancer Coach, cancer stem cells and recurrence, colon cancer, COVID-19, Integrative Oncology, Iodine, Natural Aromatase Inhibitors, prostate cancer, Uncategorized on March 28, 2020 at 9:12 am

[Editor’s note] This post was originally published in February 2017. It has been updated and republished in March 2019

It is well known that cruciferous vegetables such as broccoli and watercress contain powerful anticancer compounds. But did you know that eating their respective sprouts can supercharge the health benefits? Sprouts are high in vitamins C, A, and phytonutrients that support the immune system.

In sprout form these little three to four day old plants contain almost 100 times the level of cancer-fighting sulforaphane than the mature plants. The phytonutrients in these sprouts up-regulate antioxidant enzymes and detoxification processes which clear toxic compounds from the body. And, that is just the beginning—read on to find out how sprouts knock the socks off cancer.

What’s in a Sprout

Isothiocyanates (ITCs), such as sulforaphane, are sulfur-containing compounds found in cruciferous vegetables. They support matrix metalloproteinase-9 (MMP-9) activity which reduces the breakdown of connective tissue within a cell that impede the expansion of existing tumors. Matrix MMP-9 plays important roles in tumor invasion and angiogenesis. Secretion of MMP-9 has been reported in various cancer types including lung, colon, and breast cancer.

ITCs also kill off cancer cells, including cancer stem cells, which is essential for combating cancer metastases. Isothiocyanates restrain certain pro-inflammatory compounds that are associated with chronic inflammation and cancer.

The ITC sulforaphane helps support the anti-inflammatory Nrf2 pathway which protects cells against oxidative and free radical activity. It supports the detoxification process by inducing Phase 2 detoxification enzymes, inhibiting the activation of pro-carcinogens, and by boosting cellular glutathione levels. Sulforaphane promotes cancer cell death and inhibits cancer cell proliferation. It also supports the immune system and in particular, increases Natural Killer Cell activity.

Sulforaphane also inhibits Helicobacter pylori, the bacterium that increases one’s risk of stomach and colorectal cancer. It is also anti-viral and has been found effective against the Epstein Barr Virus and may be helpful against Coronavirus (COVID-19).

Quercetin, another potent antioxidant highly concentrated in sprouts, is a strong anti-inflammatory and prevents tumor cell growth. It also aids in the removal of excess estrogen from the body — it stimulates liver function to detoxify estrogen and other carcinogenic agents.

Lutein is another powerful antioxidant that neutralizes cancer-causing free radicals (it is also essential for many things, including eye health, protecting against macular degeneration, and for maintaining strong eye tissue). Lutein (and zeaxanthin) may be beneficial to cardio health by preventing hardening of the arteries.

Glutathione has been labeled the ‘mother of all antioxidants” due to its incredible ability to disarm free radicals, detoxify the body, and boost the immune system.

Broccoli Sprouts

broccoli-sprouts Broccoli sprouts are extremely high in cancer fighting activity, particularly against lung, colon, and breast cancers. Compounds in broccoli speed up the removal of estrogen from the body, helping to suppress breast cancer. They also target cancer stem cells, the cells responsible for metastasis.

Broccoli sprouts contain a high amount of the cancer-busting and immune boosting substance sulforaphane. They are also abundant in quercetin, glutathione, beta carotene, indoles, vitamin C, lutein, glucarate, and the metabolic substance DIM, which is a natural aromatase inhibitor.

Broccoli sprouts are rich in cholesterol reducing fiber and have anti-viral and anti-ulcer activity. They are also a super source of chromium that helps regulate insulin and blood sugar.

Watercress Sprouts

Sometimes called peppergrass, watercress is delicious and pungent. It is also one of the most nutrient-dense foods known. It is rich in beta-carotene and other carotenoids, including lutein. Watercress also offers significant quercetin, EGCG (Epigallocatechin Gallate), flavanols such a kaempferol, lycopene, indole-3 carbinol (13C), sulforaphane, as well as DIM. It is a good source of riboflavin, vitamin C, A and K, calcium, magnesium, vitamin E, and contains trace amounts of omega 3’s. Watercress is one of the best food sources of iodine for vegans.

Watercress also contains a high amount of PEITC (phenylethylisothiocyanate) which has been shown to protect DNA from damage. PEITC reduces the growth of breast cancer cells, triggers apoptosis (cancer cell death), and decreases angiogenesis. It inhibits the growth of HER2 expression as well as cancer metastasis.

PEITC (also found in some other cruciferous vegetables, including broccoli) deactivates mutant p53 in tumor cells but leaves normal p53 alone. P53 regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way. A mutation in p53 is a permanent change in the nucleotide sequence of DNA. Loss of p53 function can be deleterious, and about 50% of all human cancers have a mutated p53 gene.

Watercress has antioxidant, antigenotoxic (the process by which chemical agents damage genetic information within a cell causing mutations), and anti-inflammatory properties.

Studies show that a regular intake of watercress has been associated with protection against breast, colon, and other cancers.

Watercress and broccoli affect all stages of cancer: initiation, proliferation, and metastasis. So, what’s not to love about these sprouts? Plus, it is a lot easier to consume a handful of sprouts than it is to down a pound and a half of broccoli or an enormous plate of watercress– which, for example, is the amount it would take to get an equivalent amount of sulforaphane.

Add sprouts to your smoothies; use on sandwiches, on top of pizza, in salads, and as a garnish for soups. I make wonderful gluten-free pizza crusts using cauliflower or garbanzo bean flour, and pile the pizza high with arugula and sprouts just before serving. Yum!

Just a reminder that while eating cruciferous vegetables is a important for overall optimal health, it may support you during the COVID-19 pandemic. Choose to consume cruciferous vegetables (broccoli, Brussels sprouts, radish, and kale). It is necessary to have sufficient iodine in the diet when consuming high quantities (including DIM).

Can’t find sprouts locally or worried about others handling your raw vegetables? Grow your own. You can grow your own sprouts and now it is easier than ever (no changing the water several times a day, just add water to the tray day one and done. Here is my first tray of Hamama salad green sprouts.. Next up are broccoli sprouts. Order your own Hamama sprout kit.

Hamama Salad Green Sprouts

Here is a great book if you wish to learn more about growing your own sprouts: Year-Round Indoor Salad Gardening: How to Grow Nutrient-Dense, Soil-Sprouted Greens in Less Than 10 days

Curcera-SGS is an excellent supplement if you cannot find or grow broccoli sprouts.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

Follow Elyn on Facebook
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DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment. This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

You Can Beat Lung Cancer: Using Alternative Interventions

#1 Best Seller on Amazon for Lung Cancer Books

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aromatase inhibitors, Breast Cancer, dangers of aromatase inhibitors, dangers of SERMS, Natural Alternatives to Aromatase Inhibitors, natural alternatives to Tamoxifen, Natural remedies for Estrogen, phytoestrogens vs SERMs, prostate cancer, side effects of aromatase inhibtors, side effects of tamoxifen, Tamoxifen

Could the Natural Alternative to Tamoxifen and Aromatase Inhibitors be in Your Refrigerator? Part II

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, antioxidants, aromatase inhibitors, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, cancer stem cells and recurrence, Estrogen, Estrogen and Breast Cancer, Natural Aromatase Inhibitors, prostate cancer, SERMS, Tamoxifen, Uncategorized on November 15, 2019 at 9:07 am

Synthetic selective estrogen receptor modulators (SERMS) such as tamoxifen and pharmaceutical aromatase inhibitors are often recommended for ER+ breast and other hormone-driven cancers, but they have significant adverse effects. Is it possible that natural plant products can perform the same function without the risks and damage of pharmaceuticals? Research says they can.

While estrogen plays many important beneficial roles in humans, the proliferation of ER+ breast cancer cells can sometimes be enhanced by estrogen (especially in the absence of progesterone), which may induce multiple processes involved in cell survival and cell cycle progression. Beyond the estrogen dominance that comes from a lack of progesterone, it is not necessarily our own estrogen at fault, but more likely xenoestrogens — the chemical estrogens, environmental hazards such as BPA and BPS — Bisphenol A and S.

However, to add clarity to the estrogen equation that oncologists speak of, the body has two different estrogen receptors, ERα (alpha) and ERβ (beta). ERα has a proliferative effect, and ERβ acts as a negative regulator of ERα in breast cancer cells, counteracting the proliferative effect of estrogens. Importantly, plant estrogens (phytoestrogens) preferentially interact with ERβ and display high specificity toward ERβ transactivation. Phytoestrogens, also known as phytochemicals, are synthesized from plants and vegetables. They show low estrogenic activity or anti-estrogenic activity with anti-proliferative effects that studies show offer nutraceutical alternatives to pharmaceutical anti-hormone therapies for various cancers.[ii]

For the men reading this article (including those with breast cancer), androgens and estrogens also influence the development and progression of prostate cancer. Research shows that phytoestrogens such as soy could be used alone or in conjunction with anti-hormone therapies for prostate cancer to target metabolic pathways involved in androgen and estrogen syntheses and epigenetic modifications of DNA to promote tumor-suppressor genes.[iv]

In a nutshell, phytoestrogens may be useful as substitutes for breast cancer treatments such as tamoxifen or aromatase inhibitors, and could be extremely helpful for other hormone-related cancers.

The Role of Phytoestrogens as Replacements for SERMs and Aromatase Inhibitors

It is well-established that many foods and natural products have beneficial effects on ER+ breast cancer as well as other hormone-driven cancers. Pytoestrogens are structurally similar to our own estrogen, but functionally are weakly estrogenic (weakly mimicking estrogen) or antiestrogenic (blocking estrogens’ effects). They have been researched extensively for their role in the interaction with estrogen receptors. The beauty is that they block the receptors from more volatile estrogens. As such, they deserve consideration in preventive and therapeutic settings for the intervention of cancer initiation and progression.

Studies show that phytoestrogens may provide an alternative or complementary approach to anti-hormone treatments. For example, 2017 research published in the International Journal of Molecular Sciences cited many studies confirming that an important application of phytoestrogens is that they could be used as an alternative to the SERMs.[iii] In general, phytoestrogens act as aromatase inhibitors by decreasing aromatase gene expression and inhibiting the aromatase enzyme.

Some of the more powerful phytoestrogens include flax and sesame seeds as well as whole soy.

Flax and sesame seeds have anticancer, breast tumor-reducing effects. Both lignans are metabolized to estrogen-like enterodiol and enterolactone, and reduce cell proliferation and apoptosis.[xiv] While each works a bit differently, both may be useful as an effective adjuvant therapeutic agent against tumor development and progression, and therefore, could be used in the prevention and/or treatment of various types of cancer. Studies show that higher intakes of lignans such as flax and sesame seeds are associated with a reduced risk of breast cancer. Flax seed works with tamoxifen to inhibit breast cancer tumor growth, so if you choose to take tamoxifen, know that you can also benefit from flax.

I have written extensively on the benefits of flax seed, but to recap, a few of the benefits of flax are the following:

Decreases cell proliferation rates and inhibits tumor growth in ER+ cancers
Decreases angiogenesis (blood supply for tumors) and increases apoptosis (cancer cell death)
Influences ER-negative and ER-positive tumors by decreasing insulin-like growth factor-1 (IGF-1), epidermal growth factor receptor (EGFR), HER2 and the vascular endothelial growth factor (VEGF) which supports angiogenesis
Reduces growth and metastasis of ER-negative and triple negative breast cancers
Favorably influences tumor suppressor genes

For more on flax seed and breast cancer, please read some of my other posts, such as Demystifying Flaxseed and Estrogen and Flaxseed, Better Than Tamoxifen for Breast Cancer.

Soy: Numerous studies indicate that genistein, the most abundant isoflavone present in soybeans, has anti-proliferative effects on various cancer cells, including prostate, ovarian, and breast. Like other phytoestrogens, genistein interferes with the effects of estradiol by binding to estrogen receptors. This is good as soy may also inhibit inflammation and boost anticancer immune responses, while other estrogens do not. The following are a few key findings of soy[v]:

Inhibits NF-kB activity in prostate, breast, lung, and pancreatic cancer cells. Nf-kB plays a crucial role in immune response, inflammation, cell growth and survival.
Selective tyrosine kinase inhibitor impeding angiogenesis, a major factor in cancer growth and proliferation. Tyrosine kinases play important roles in cell proliferation, survival, migration and differentiation are often altered in cancer cells, leading to malignancy
Induces cancer cell death (apoptosis) in several cancer cell lines, including prostate, ovarian, and breast cancer
Modulates EGF (epidermal growth factor) which has been implicated in the development and growth of many types of cancer cells
Long-term consumption seems to result in a decreased response to stimulation by estradiol[vi]

Please note that soy consumption is somewhat controversial. Please work with your coach or medical professional to see if soy consumption is right for you.

More Notable Phytoestrogens

Apigenin is a natural flavonoid commonly found in fruits and vegetables such as parsley, celery, thyme, chamomile tea, and oranges. The chemical structure of apigenin is similar to estrogen and as such it mimics estrogen. 2107 research indicates that phytoestrogens such as apigenin and resveratrol have the therapeutic potential act like SERMs and could be considered in the development of therapeutics for breast cancer and brain disease.[vii] Extensive studies show that apigenin has potent antioxidant and anticancer activities in ER-positive and ER-negative breast cancer. Apigenin also inhibits proteasome, which certain cancer cells need for survival. By inhibiting proteasome, phytoestrogens such as apigenin induce apoptosis in prostate, breast, and many other cancer cell lines.[viii]
Pau d’ Arco exhibits selective anti-proliferative effects in carcinoma cell lines. A study performed at the Strang Cancer Prevention Center in New York found that the anti-proliferative effects of herbal medicines such as pau d’arco may correlate with down-regulated estrogen responsive genes and up-regulated apoptosis-specific genes. The researchers believe their data validates the need to prioritize efficacious herbal medicines and concluded that phytoestrogens such as pau d’arco may provide an alternative or complementary approach to endocrine therapy for breast cancer.[ix] Read more
Broccoli: The sulforaphane in broccoli (particularly in broccoli seeds and sprouts) has been found to inhibit proliferation and down-regulates hormone receptor expression in MCF-7 cells. Sulforaphane also passes the blood brain barrier and targets cancer stem cells. If you cannot find sprouts locally, I recommend a supplement.

Luteolin and Naringenin: Flavonoids, especially flavones such as luteolin and flavanones such as naringenin are potent aromatase inhibitors. [x] Luteolin has also been found to down-regulate aromatase gene expression. Luteolin is found in celery, thyme and chamomile tea. Some rich sources of naringenin include bergamot, grapefruit, tomatoes, and tart cherries.
Quercetin, found in abundance in food sources such as apples, onions, tea, and red wine, has been reported to have strong antioxidant, anti-inflammatory, antiviral, and anticancer effects. It has the ability bind at high affinity to estrogen receptors, resulting in inhibition of estrogen-regulated cell growth and proliferation[xi]
Hesperetin, found in citrus fruits and essentials oils, exerts it anticancer actions by inhibiting cell proliferation, inducing apoptosis, and by regulating aromatase activity and oxidative stress. Although hesperetin is unable to bind to ERs, it is effective in inhibiting cell proliferation of ER+ breast cancer and dramatically decreasing tumor size and other actions. Hesperetin has also been found to reduce serum estrogen levels and down-regulate estrogen target genes and estrogen metabolism-related genes.[xii]. Try putting a drop or two of lemon essential oil in your water, or grating the peel of an organic lemon.
Black seed contains thymoquinone, a phytochemical compound found in plant Nigella sativa. It has been found to initiate apoptosis, improve estrogen metabolism, and regulate signally pathways in breast cancer.
Vitamin E inhibits cell proliferation, down-regulates the expression of ERα, ERβ, COX-2, and serum estrogen levels (should always be mixed tocopherols, not just d-alpha.
Red Clover binds to estrogen receptors, inhibits cell proliferation, and initiates apoptosis in ER+ breast cancer cells.
Ellagic acid, a dietary flavonoid present in berries, grapes, pomegranates, and nuts, inhibits cell proliferation and promotes apoptosis in ER+ breast cancer cells.
Eugenol, a compound found in clove oil, inhibits cell proliferation and initiates cancer cell death in both ER+ and ER- breast cancers. Excitingly, one study done in Indonesia found that eugenol is a potent ERa antagonist. The researchers indicate that not only does it work just like tamoxifen, but it may actually work even better.
This list is not inclusive: There are many more powerful phytoestrogens. For more cancer-fighting alternatives to pharmaceuticals, please read my articles on Natural Alternatives to Aromatase Inhibitors and Natural Alternatives to Tamoxifen.

Phytoestrogens can be our friends, but know that herbs are powerful. I have no concerns with food-based phytos, but do take care with extracts. They are best rotated so as to maximize benefits, reduce the chances of resistance, and avoid interactions. Drugs, of course, are often even more dangerous, yet are routinely prescribed.

Trust me, I’m a doctor” Peter Gøtsche

I interviewed Peter Gøtsche, author of Deadly Medicines and Organised Crime, on my radio show a few years back. Amazing man, whose controversial views have since gotten him tossed from the Cochrane Collaboration, which he co-founded. Sadly, there are many who wish to silence the voices who speak against Big Pharma.

Like me, Gøtsche worries that most people let their doctors make the decisions for them, but the evidence tells us that we should be cautious. He is a strong advocate for the avoidance of drugs and while not against medical interventions, believes one can not just blindly follow the orders of the medical community.

Notably, there is tremendous variability in the metabolic processing of phytoestrogens and pharmacological drugs, thus establishing the difficulty and complexity of this topic. The bottom line is that it extremely important that one understand that it may not make logical sense to attempt to poison one’s way back to health. Certainly drug therapies have worked for many. That said, NO ONE was every born tamoxifen or AI deficient, but over time we may become estrogen dominant, increasing our risk for cancer. It behooves us all to do our research and decide for ourselves whether drugs or holistic remedies are best, or even a combination of both.

Estrogen plays many important roles in humans, so it may not make sense to arbitrarily take it away. If you are estrogen dominant (meaning out of balance with progesterone), you may want to consider a bio-identical progesterone cream (I like that one as it is paraben-free, soy-free, and Non GMO).

Read Part I of this article HERE.

Reminder: To get an additional $30 off on the online course for breast cancer, Toxic Free Me, enroll now and use this LINK. This course will further delve into alternatives for anti-hormonal therapies.

An online course not right for you? Know that I am always there for individual consultations. To inquire about a consult, please visit me HERE.

Life is a journey, just be sure that journey is on-course for a healthy life.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment. This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Follow Elyn on Facebook

Follow Elyn on LinkedIn

[i] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; Notably, there are numerous crsos-references cited in this article that support the use of phytoestogens as nutraceutical anti-hormone therapies for various cancers.

[ii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[iii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/

[iv] https://www.ncbi.nlm.nih.gov/pubmed/27194038; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[v] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/#B61-ijms-18-01381; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[vi] https://www.ncbi.nlm.nih.gov/pubmed/8625449

[vii] https://www.ncbi.nlm.nih.gov/pubmed/28396216; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033666/

[viii] https://www.ncbi.nlm.nih.gov/pubmed/26771497; https://www.ncbi.nlm.nih.gov/pubmed/25408199

[ix] https://www.ncbi.nlm.nih.gov/pubmed/19578798

[x] https://www.ncbi.nlm.nih.gov/pubmed/21741436

[xi] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203161/#b9

[xii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[xiii] https://www.ncbi.nlm.nih.gov/pubmed/26614455

[xiv] https://elynjacobs.com/2016/02/28/flaxseed-better-than-tamoxifen-for-breast-cancer/; https://www.ncbi.nlm.nih.gov/pubmed/29032105; https://www.ncbi.nlm.nih.gov/pubmed/22136581

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cash register receipts and breast cancer, Flaxseed and Breast Cancer, foods that boost estrogen, foods that lower estrogen, low estrogen and aromatase inhibitors, Natural Alternatives to Aromatase Inhibitors, natural alternatives to Tamoxifen, parabens and breast cancer, phytoestrogens and breast cancer, post menopausal symptoms, xenoestrogens and breast cancer

What to Do if You Have Low Estrogen Levels and Your Doctor Prescribes an Aromatase Inhibitor

In Alternative Cancer Therapies, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, Boosting Estrogen, BPA and breast cancer, Breast Cancer, Natural Aromatase Inhibitors, Uncategorized on May 17, 2018 at 9:00 am

Despite the fact that estrogen is essential for both quality and quantity of life, aromatase inhibitors (AIs) are regularly prescribed to most post-menopausal women with estrogen-sensitive breast cancer — even if they have low estrogen levels. AIs are associated with numerous life-challenging issues such as heart damage, osteoporosis, musculoskeletal symptoms, and increased risk of bone fracture. AI treatment reduces nearly all circulating estrogen which exacerbates post-menopausal symptoms and increases mortality.

Most of my post-menopause clients have VERY LOW ESTROGEN LEVELS. This is important to note as the last thing they need is even lower estrogen levels. Many, in fact, have low estrogen across the board (meaning the pro-cancer as well as protective estrogens). Often they have low progesterone as well, so their hormones are actually in balance, offering protection against breast cancer. (While progesterone, in most cases, is protective, it is good to be balanced). However, low hormone levels leave these women with unpleasant symptoms and an increased risk of debilitating and life-threatening issues. Plus, when I look further at their labs they often even have favorable estrogen metabolism, which is also associated with a reduced risk of breast cancer. (More on estrogen metabolism in a pending post). It simply makes no sense to block the production of estrogen in most post-menopausal women even if they have breast cancer. (For more information on why aromatase inhibitors may not be right for you, please read: Why You May Want to Reconsider Estrogen-Blocking Aromatase Inhibitors and Tamoxifen).

So, what can you do if you have estrogen-receptor positive breast cancer? First of all, it is important to resolve the real reason for the cancer. Estrogen may feed it, but does not really cause it. Environmental toxins, emotional trauma, and viruses such as Epstein-Barr are some of the most common triggers. Lowering estrogen with a harmful drug will not resolve any of these issues and may be detrimental to your health. If you have high estrogen, there are natural alternatives to AIs; please read: Natural Alternatives to Hormone Therapy for Breast Cancer. If you have low estrogen or even if you don’t, read on:

Estrogen is Essential

We need estrogen for aiding in the prevention of heart disease and for strong, healthy bones. In fact, estrogen is essential to the health of all parts of your body, from your eyes to your heart to your brain to everywhere else. Estrogen also increases insulin sensitivity and is protective against diabetes.

In general, estrogens are not always bad, and some are even protective, particularly Estriol (E3). True, Estradiol (E2) can stimulate cancer cell proliferation, but not when opposed by sufficient progesterone. Keeping one’s progesterone levels up will offset your own more aggressive Estradiol. Sad that most doctors do not order hormone panels prior to subjecting patients to aromatase inhibitors.

Xenoestrogens (chemical estrogens), however, should always be avoided. Xenoestrogens are chemicals that mimic natural estrogen compounds. They are close enough in molecular structure to estrogen that they can bind to estrogen receptor sites and stimulate proliferation of human breast cancer cells. Some examples of xenoestrogens are BPA (bisphenol A), found in plastics, paper products, cash register receipts, plant pesticides, and can linings, and parabens, which are found in many personal care products, cleaning products, and scented candles.

Boosting Estrogen

If you have low estrogen and would like to increase it, consider consuming more flaxseed, pumpkin seeds, and other phytoestrogens (plant estrogens). Phytoestrogens are plant derivatives that have a similar structure to estrogen and can bind to the estrogen receptor sites. They are weaker endogenous estrogens and, through competitive inhibition, can prevent the receptor binding of more potent estrogens. These will not raise your risk of breast cancer, and can actually lower it.

Importantly, research conducted by the Linus Pauling Institute of Oregon State University indicated that eating plant-based foods that contain phytoestrogens may help women raise estrogen levels, relieving symptoms of low estrogen.[i]

herbs Estrogen

The increased cancer risk associated with anti-hormone therapies has encouraged many women to seek non-hormonal alternatives. Many foods, such as herbs, grains, vegetables and fruits provide compounds with estrogen-like effects. Below is a list of some plant-estrogens you may wish to add to your diet:

Seeds such as flax, pumpkin, poppy, sunflower, and sesame
Apricots, oranges, strawberries, peaches, many dried fruits
Yams, carrots, alfalfa sprouts, kale, celery
Soy foods such as tempeh, tofu, miso soup, and soy yogurt (all soy should be organic and with no sugar added).
Dark rye bread
Lentils, peas, lima beans, pinto beans
Olives and olive oil
Chickpeas
Fresh herbs, such as parsley, sage, rosemary, and thyme
Licorice root*

Here’s what you really need to know. Estrogenic cancers can be managed with a sensible diet and lifestyle changes. Drugs are not necessary to manage estrogen, and in fact will often fail for many reasons, as addressed in the links below. What women with breast cancer are rarely told is that in lieu of taking harmful medication (which creates its own set of problems and serious side effects), they can adapt diet and lifestyle strategies which can effectively reduce high levels of the antagonistic estrogen, estradiol.

If you still suffer from low-estrogen symptoms despite a change in diet or other lifestyle activities, then you may want to consider bio-identical hormones such as an inexpensive cream.

*I want to highlight one phytoestrogen that seems to worry many women with breast cancer–licorice root. There is no cause for alarm. In fact, licorice root has anti-inflammatory, antibacterial, antiviral, antiangiogenetic (meaning it inhibits cancer cells from generating their own blood vessels), and other anti-cancer properties. Licorice root is toxic to human cancer cells, but not to healthy cells. It also promotes an increase in progesterone by inhibiting the enzyme necessary for its breakdown, which helps to block the cancerous activity of estradiol, the most potent form of estrogen created within the body. Further, it is an adaptogenic herb, so if your estrogen is too low, it will increase it, and if it is too high, it will bring it down. Licorice root tea is a delicious way to enjoy this herb. It is not advised to take licorice root during pregnancy or for those with high blood pressure, or for extended periods of time unless under the direction of a professional. Use of any medicinal herb should always be done under the direction of a knowledgeable physician or professional.

You may also wish to read:

Why You May Want to Reconsider Estrogen-Blocking Aromatase Inhibitors and Tamoxifen

Natural Alternatives to Hormone Therapy for Breast Cancer

Vitamin D Better than Aromatase Inhibitors

Natural Alternatives to Tamoxifen

Natural Alternative to Aromatase Inhibitors

Why Aromatase Inhibitors Fail Women

You may wish to read my articles on flaxseed:

Demystifying Flaxseed and Estrogen

Flaxseed: Better Than Tamoxifen for Breast Cancer

Flaxseed: The Anti-Cancer Power Seed

To read about one of the major contributors to most cancers, please read this article on Epstein-Barr and Cancer.

This information is for educational purposes only and is not a recommendation to forgo anti-hormone therapy. It is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist and make your own decisions. The information provided is from my research and not to be taken as scientific evidence.

Elyn

~~If you don’t know your options, you don’t have any~~

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[i] https://www.aao.org/eyenet/article/watch-ocular-effects-of-breast-cancer-drugs

[i] http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/lignans

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