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Archive for the ‘SERMS’ Category

Natural Alternatives to Anti-Hormone Therapies for Breast Cancer: What your Doctor May Know but Cannot Recommend

In Alternative Cancer Therapies, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer diet, Anticancer foods, foods for colon cancer, foods for breast cancer, aromatase inhibitors, Bio-Identical Hormones, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, colon cancer, Estrogen, Estrogen and Breast Cancer, Healing Cancer Naturally, Hormone Balance, Natural Alternatives to Aromatase Inhibitors, SERMS, Tamoxifen, Uncategorized on April 27, 2021 at 2:12 pm

Natural alternatives to anti-hormone therapies have been well-known for a long time. Oncologists are often hesitant to recommend them as they are required to stick to the ‘standard of care’ (SOC), which limits them to drugs such as tamoxifen or aromatase inhibitors. That does not mean they are not aware that there are alternatives that can be as good or even better than pharmaceutical drugs. However, alternatives are typically not taught in medical school and your doctor may not feel comfortable in recommending them even if s/he could.

So, what can you do?

There are many things you can do to balance your hormones naturally and minimize the cancerous effects of your own estrogen and more importantly, the chemical estrogens in your world. Chemical estrogens (xeno-estrogens) may include but are not limited to chemicals such as BPA (bisphenol A) as would be found in beauty and home products, weed killers, insecticides, and pesticides (especially glyphosate). Oral contraceptives, cash register receipts, plastics, and paper products such as toilet paper and paper towels are also problematic. When too many of these aggressive estrogen molecules occupy estrogen receptor sites, this is when cancer can grow. The first and foremost thing to do is to get these things out of your life as much as possible. Buy organic foods, free of pesticides and GMOs whenever possible. Aim for a variety of 8-10 servings of vegetables and 2-4 servings of fruit daily. Limit processed and packaged foods and use only clean home and personal care products.

Certain nutrients, botanicals, and nutrient compounds impact the body’s ability to process toxins. Top choices are cruciferous vegetables, garlic, onions (red, white, chives, leeks, scallions, and shallots), parsley, leafy greens, turmeric, berries, lemon water, green tea, beets, flax seeds, and artichokes. Consume these regularly to support your body’s natural detoxification systems. Drinking pure water and sweating are very helpful too!

For information about helpful supplements for estrogen management and detoxification, visit the Supplement Page on my website or request my handouts.

The Role of Phytoestrogens

A number of nutrients, botanicals, and nutrient compounds have varying effects on the cancerous process. You may have been told by your doctor to avoid phytoestrogens (plant estrogens), but these substances can inhibit breast cancer! Phytoestrogens are plant compounds with a similar molecular shape and structure to endogenous estrogen molecules. Phytoestrogens such as flax and sesame seeds work like SERMS (selective estrogen receptor modulators) such as tamoxifen. They modulate the effects of estrogen in the body by connecting to their receptors (just as tamoxifen does) thus inhibiting cancer cell replication.

Seeds such as flax and sesame contain lignans, molecules that bind to estrogen receptors just like tamoxifen. Binding turns on, or activates, a hormone receptor. Activation sets in motion cell signaling systems that trigger gene expression. In other words, phytoestrogens are similar enough to estrogen that they can bind to estrogen receptors, but cancer cells cannot use them in the same way as your own natural estrogen or chemical estrogens (they are far less potent). Lignans activate far weaker than your own estrogen or chemical estrogens. What this means is that they cannot stimulate breast cells to divide. They ‘park’ on the estrogen receptors, essentially blocking harmful estrogens from being able to bind to that receptor and do the dirty deed.

Further, flax and sesame seeds reduce tumor growth by increasing cell death and decreasing angiogenesis (the growth of new blood vessels that allow cancer to advance). Flaxseed has also been found to knock down (inhibit) CYP1B1, an enzyme that plays a role in estrogen metabolism. CYP1B1 converts estrogen to the less favorable metabolites. CYP1B1 also tends to make environmental toxins more carcinogenic. It is expressed in ovarian, uterine, and breast tissues and is implicated in colon cancer as well.

Read more about the lignans in flax and sesame seed in my articles Demystifying Flaxseed and Estrogen and Gluten-Free Anticancer, Anti-inflammatory Seeded Flatbread.

Soy is another powerful phytoestrogen that only weakly interacts with receptors. Plus, for many people, the genistein in soy works hard to inhibit cancer growth factors. Soy is a bit more controversial as in some people it can interfere with thyroid function, so speak with your doctor before consuming it.

There are many other phytoestrogens that inhibit the estrogen-related cancerous process. I focused on the seeds and soy as the information on these can be confusing. Fennel, clove, citrus peels, clary sage, and myrrh are a few other good ones.

Natural Aromatase Inhibitors

For women who have an over-abundance of natural estrogen (again, often a result of toxin overload, imparied estrogen metabolism, and chronic stress), reducing aromatase might be helpful. However, it is not necessary to rely on pharmaceutical aromatase inhibitors (loaded with terrible side effects) to lower the production of aromatase (which produces estrogen). Eat foods such as button mushrooms, celery and parsley (rich in apigenin), rosemary, citrus peel, pumpkin seeds, and flaxseed. Supplements such as D3, DIM, vitamin K2, calcium D-glucarate, zinc, grapeseed extract, gingko biloba, myomin, chrysin, red wine, and sea cucumber are natural aromatase inhibitors as well.

Importantly, many women do not need to and should not reduce estrogen, particularly if they have extremely low levels. I caution you not to severely inhibit estrogen, either by holistic or pharmaceutical means. Low estrogen contributes to osteoporosis, heart disease, ocular damage[i], and so much more. Sadly, doctors often order aromatase inhibitors for people without even testing hormone levels.

That said, even if estrogen levels are low, it is still essential to metabolize and excrete estrogen, the way nature intended to be.

Estrogen is NOT always the Problem

All of that said, estrogen is NOT always the problem. Most people who suffer from hormone imbalance are deficient in progesterone. Progesterone sort of puts the brakes on estrogens’ cancerous activity. While you can use a progesterone cream or perhaps use bioidentical, I would encourage you to try to balance your hormones with diet and supplements.  

Things that help raise progesterone are stress reduction, zinc, thyme, vitamin C, magnesium, cruciferous vegetables, vitamin E, Chaste Tree (Vitex), and activated B6 (also available in food sources such as leafy greens, peppers, carrots, asparagus, broccoli, walnuts, eggs, sweet potatoes, and sunflower seeds. For the carnivores, you can find it in grass-fed beef and beef liver). Activated B6 is necessary for the synthesis of progesterone. It is also necessary for the liver to metabolize and break down estrogen, which can help reduce estrogen dominance. You can find activated B6 here at Amazon or at your local drugstore.

Good info on progesterone in this article, Eternity: Quite Possibly the Best Bio-Identical Progesterone Cream

Estrogen Metabolism and Methylation

Estrogen metabolism and methylation play a role in hormone-sensitive cancers. To control the level of estrogen in the body, we need a way to break it down and eliminate it. This is mostly done by the liver, where enzymes create metabolites, known as catechol estrogens, that can either be favorable or less favorable for estrogen metabolism. Supplements such as DIM, Indole-3-Carbinol and Calcium-d-glucarate (not calcium) support healthy metabolism and elimination of estrogen. That said, not everything is right for everyone, so you may want to do some testing to see what works best for you.

A simple blood test is one option if you just want an idea of your hormone levels. However, because hormone levels vary day to day as well as throughout the day, a blood test may not accurately reflect hormone levels. It will also not provide information regarding methylation and pathways. But it is a start.

Saliva tests are another option, which are believed to test hormones at the cellular level, as opposed to the blood test with measures the level of hormones circulating in the blood stream. You can purchase home kits. See my supplement page if you need recommendations.

The Dutch Test can give you a baseline measurement of hormonal imbalances. It will show you what your estrogen profile looks like and what pathway the estrogens are headed down. Among a lot of other things, it will show methylation and even if things such as DIM, for example, are working for you or against you. For more information see their website.

The Nutrition Genome Test looks at the genetic gene mutations (inherited DNA alterations) you may have been born with that could be affecting estrogen metabolism and driving the growth of cancer.

For example, COMT is a gene that plays a role in methylation and estrogen metabolism. If you have variants of this gene, you might have sluggish methylation. However, it does not affect everyone the same way and can be driven by diet and lifestyle choices, stress, and exposure to environmental toxins such as cigarette smoke. ‘Healthy’ things such as quercetin, resveratrol, cilantro, green tea, and others can further slow COMT in some people and may need to be avoided. The supplement SAMe can help those with COMT, depending on your genetic makeup.

Genomic testing, like many other ‘tests’ is not right for everyone. If you believe you will be super-stressed by finding out what SNPs you have (DNA variants) then you might want to skip the tests. Most variants are quite common, so don’t freak out if you have one or even all of the variants linked to cancer. Lots of things are linked to cancer.

Our gut, brain, and bodies in general are often the most powerful test. Listen to your gut –it is trying to tell you something. Connect with yourself and do not go with what others are doing just for the sake of following the crowd.

Importantly, our genes are NOT our destiny. It is how we ‘talk’ to them that matters. We ‘talk’ to your genes with thoughts and food choices. A great read on this is Dr Mitch Gaynor’s’ The Gene Therapy Plan: Taking Control of Your Genetic Destiny with Diet and Lifestyle.

Keep that Estrogen Moving!

Estrogen that has been metabolized and is ready to be eliminated through feces can be recycled back into circulation either due to chronic constipation or an interaction with certain bacteria in the gut, such as beta-glucuronidase. Calcium d-glucarate suppresses beta-glucuronidase helping you excrete the estrogen metabolites. Adding more fruits and vegetables may help ease constipation.  

So, you can see that estrogen is far more complicated with respect to its role in cancer than you may have been led to believe. Hormones can be very confusing!! Importantly, estrogen and progesterone levels are not to be confused with receptor status!!! For more clarification on that, visit me in my private Facebook group Cancer Coach Elyn as I post on this often, or schedule a consult with me.

There are many more substances that improve hormonal balance, stimulate the livers’ detoxification systems, and inhibit cellular proliferation, but if I listed them all this post would get too long. But, blocking estrogen is not the most important factor for many breast cancer patients. Addressing the cancerous terrain that may have allowed cancer to present is crucial. Chronic inflammation, GMOs, emotional and environmental toxins, viruses, obesity, and other factors are all involved.

Read Also: Natural Ways to Balance and Manage Hormones for Breast Cancer as well as my articles on natural alternatives to anti-hormone therapies.

The above information is not to be considered to be a cancer treatment, but rather to provide information that may improve health. The information provided is for general information only. No online site should be used as a substitute for personal medical attention. If you’d like more guidance, I’d love to work with you! Check out my “Contact Us” page or email elyn@elynjacobs.com for more details.

I have started a new private group on Facebook, Cancer Coach Elyn. If interested, you can visit it HERE. Please do not forget to answer the group questions if you would like to join.

Elyn

~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer but surviving well and reducing the risk of recurrence. Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit http://www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment. This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice, nor should it be considered to be medical advice or a replacement for medical advice. I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Some product links on some posts are affiliate links. This website is monetized in part using affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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[i] file:///C:/Users/elyn/Downloads/[14796805%20-%20Journal%20of%20Endocrinology]%20Oestrogen,%20ocular%20function%20and%20low-level%20vision_%20a%20review.pdf

Could the Natural Alternative to Tamoxifen and Aromatase Inhibitors be in Your Refrigerator? Part II

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, antioxidants, aromatase inhibitors, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, cancer stem cells and recurrence, Estrogen, Estrogen and Breast Cancer, Natural Aromatase Inhibitors, prostate cancer, SERMS, Tamoxifen, Uncategorized on November 15, 2019 at 9:07 am

Synthetic selective estrogen receptor modulators (SERMS) such as tamoxifen and pharmaceutical aromatase inhibitors are often recommended for ER+ breast and other hormone-driven cancers, but they have significant adverse effects. Is it possible that natural plant products can perform the same function without the risks and damage of pharmaceuticals? Research says they can.

While estrogen plays many important beneficial roles in humans, the proliferation of ER+ breast cancer cells can sometimes be enhanced by estrogen (especially in the absence of progesterone), which may induce multiple processes involved in cell survival and cell cycle progression. Beyond the estrogen dominance that comes from a lack of progesterone, it is not necessarily our own estrogen at fault, but more likely xenoestrogens — the chemical estrogens, environmental hazards such as BPA and BPS — Bisphenol A and S.

However, to add clarity to the estrogen equation that oncologists speak of, the body has two different estrogen receptors, ERα (alpha) and ERβ (beta). ERα has a proliferative effect, and ERβ acts as a negative regulator of ERα in breast cancer cells, counteracting the proliferative effect of estrogens. Importantly, plant estrogens (phytoestrogens) preferentially interact with ERβ and display high specificity toward ERβ transactivation. Phytoestrogens, also known as phytochemicals, are synthesized from plants and vegetables. They show low estrogenic activity or anti-estrogenic activity with anti-proliferative effects that studies show offer nutraceutical alternatives to pharmaceutical anti-hormone therapies for various cancers.[ii]

For the men reading this article (including those with breast cancer), androgens and estrogens also influence the development and progression of prostate cancer. Research shows that phytoestrogens such as soy could be used alone or in conjunction with anti-hormone therapies for prostate cancer to target metabolic pathways involved in androgen and estrogen syntheses and epigenetic modifications of DNA to promote tumor-suppressor genes.[iv]

In a nutshell, phytoestrogens may be useful as substitutes for breast cancer treatments such as tamoxifen or aromatase inhibitors, and could be extremely helpful for other hormone-related cancers.

The Role of Phytoestrogens as Replacements for SERMs and Aromatase Inhibitors

It is well-established that many foods and natural products have beneficial effects on ER+ breast cancer as well as other hormone-driven cancers.  Pytoestrogens are structurally similar to our own estrogen, but functionally are weakly estrogenic (weakly mimicking estrogen) or antiestrogenic (blocking estrogens’ effects). They have been researched extensively for their role in the interaction with estrogen receptors. The beauty is that they block the receptors from more volatile estrogens.  As such, they deserve consideration in preventive and therapeutic settings for the intervention of cancer initiation and progression.

Studies show that phytoestrogens may provide an alternative or complementary approach to anti-hormone treatments. For example, 2017 research published in the International Journal of Molecular Sciences cited many studies confirming that an important application of phytoestrogens is that they could be used as an alternative to the SERMs.[iii] In general, phytoestrogens act as aromatase inhibitors by decreasing aromatase gene expression and inhibiting the aromatase enzyme.   

Some of the more powerful phytoestrogens include flax and sesame seeds as well as whole soy. 

Flax and sesame seeds have anticancer, breast tumor-reducing effects. Both lignans are metabolized to estrogen-like enterodiol and enterolactone, and reduce cell proliferation and apoptosis.[xiv] While each works a bit differently, both may be useful as an effective adjuvant therapeutic agent against tumor development and progression, and therefore, could be used in the prevention and/or treatment of various types of cancer. Studies show that higher intakes of lignans such as flax and sesame seeds are associated with a reduced risk of breast cancer. Flax seed works with tamoxifen to inhibit breast cancer tumor growth, so if you choose to take tamoxifen, know that you can also benefit from flax.  

I have written extensively on the benefits of flax seed, but to recap, a few of the benefits of flax are the following:

  • Decreases cell proliferation rates and inhibits tumor growth in ER+ cancers
  • Decreases angiogenesis (blood supply for tumors) and increases apoptosis (cancer cell death)
  • Influences ER-negative and ER-positive tumors by decreasing insulin-like growth factor-1 (IGF-1), epidermal growth factor receptor (EGFR), HER2 and the vascular endothelial growth factor (VEGF) which supports angiogenesis
  • Reduces growth and metastasis of ER-negative and triple negative breast cancers
  • Favorably influences tumor suppressor genes

For more on flax seed and breast cancer, please read some of my other posts, such as  Demystifying Flaxseed and Estrogen and Flaxseed, Better Than Tamoxifen for Breast Cancer.

Soy: Numerous studies indicate that genistein, the most abundant isoflavone present in soybeans, has anti-proliferative effects on various cancer cells, including prostate, ovarian, and breast. Like other phytoestrogens, genistein interferes with the effects of estradiol by binding to estrogen receptors. This is good as soy may also inhibit inflammation and boost anticancer immune responses, while other estrogens do not. The following are a few key findings of soy[v]:

  • Inhibits NF-kB activity in prostate, breast, lung, and pancreatic cancer cells. Nf-kB plays a crucial role in immune response, inflammation, cell growth and survival.
  • Selective tyrosine kinase inhibitor impeding angiogenesis, a major factor in cancer growth and proliferation. Tyrosine kinases play important roles in cell proliferation, survival, migration and differentiation are often altered in cancer cells, leading to malignancy
  • Induces cancer cell death (apoptosis) in several cancer cell lines, including prostate, ovarian, and breast cancer
  • Modulates EGF (epidermal growth factor) which has been implicated in the development and growth of many types of cancer cells
  • Long-term consumption seems to result in a decreased response to stimulation by estradiol[vi]

Please note that soy consumption is somewhat controversial. Please work with your coach or medical professional to see if soy consumption is right for you.

More Notable Phytoestrogens                                                                            parsley root

  • Apigenin is a natural flavonoid commonly found in fruits and vegetables such as parsley, celery, thyme, chamomile tea, and oranges. The chemical structure of apigenin is similar to estrogen and as such it mimics estrogen. 2107 research indicates that phytoestrogens such as apigenin and resveratrol have the therapeutic potential act like SERMs and could be considered in the development of therapeutics for breast cancer and brain disease.[vii] Extensive studies show that apigenin has potent antioxidant and anticancer activities in ER-positive and ER-negative breast cancer. Apigenin also inhibits proteasome, which certain cancer cells need for survival. By inhibiting proteasome, phytoestrogens such as apigenin induce apoptosis in prostate, breast, and many other cancer cell lines.[viii]
  • Pau d’ Arco exhibits selective anti-proliferative effects in carcinoma cell lines. A study performed at the Strang Cancer Prevention Center in New York found that the anti-proliferative effects of herbal medicines such as pau d’arco may correlate with down-regulated estrogen responsive genes and up-regulated apoptosis-specific genes. The researchers believe their data validates the need to prioritize efficacious herbal medicines and concluded that phytoestrogens such as pau d’arco may provide an alternative or complementary approach to endocrine therapy for breast cancer.[ix] Read more
  • Broccoli: The sulforaphane in broccoli (particularly in broccoli seeds and sprouts) has been found to inhibit proliferation and down-regulates hormone receptor expression in MCF-7 cells. Sulforaphane also passes the blood brain barrier and targets cancer stem cells. If you cannot find sprouts locally, I recommend a supplement.sprouts
  • Luteolin and Naringenin: Flavonoids, especially flavones such as luteolin and flavanones such as naringenin are potent aromatase inhibitors. [x] Luteolin has also been found to down-regulate aromatase gene expression. Luteolin is found in celery, thyme and chamomile tea. Some rich sources of naringenin include bergamot, grapefruit, tomatoes, and tart cherries.
  • Quercetin, found in abundance in food sources such as apples, onions, tea, and red wine, has been reported to have strong antioxidant, anti-inflammatory, antiviral, and anticancer effects. It has the ability bind at high affinity to estrogen receptors, resulting in inhibition of estrogen-regulated cell growth and proliferation[xi]
  • Hesperetin, found in citrus fruits and essentials oils, exerts it anticancer actions by inhibiting cell proliferation, inducing apoptosis, and by regulating aromatase activity and oxidative stress. Although hesperetin is unable to bind to ERs, it is effective in inhibiting cell proliferation of ER+ breast cancer and dramatically decreasing tumor size and other actions. Hesperetin has also been found to reduce serum estrogen levels and down-regulate estrogen target genes and estrogen metabolism-related genes.[xii]. Try putting a drop or two of lemon essential oil in your water, or grating the peel of an organic lemon.
  • Black seed contains thymoquinone, a phytochemical compound found in plant Nigella sativa. It has been found to initiate apoptosis, improve estrogen metabolism, and regulate signally pathways in breast cancer.
  • Vitamin E inhibits cell proliferation, down-regulates the expression of ERα, ERβ, COX-2, and serum estrogen levels (should always be mixed tocopherols, not just d-alpha.
  • Red Clover binds to estrogen receptors, inhibits cell proliferation, and initiates apoptosis in ER+ breast cancer cells.
  • Ellagic acid, a dietary flavonoid present in berries, grapes, pomegranates, and nuts, inhibits cell proliferation and promotes apoptosis in ER+ breast cancer cells.
  • Eugenol, a compound found in clove oil, inhibits cell proliferation and initiates cancer cell death in both ER+ and ER- breast cancers. Excitingly, one study done in Indonesia found that eugenol  is a potent ERa antagonist. The researchers indicate that not only does it work just like tamoxifen, but it may actually work even better.
  • This list is  not inclusive: There are many more powerful phytoestrogens. For more cancer-fighting alternatives to pharmaceuticals, please read my articles on Natural Alternatives to Aromatase Inhibitors and Natural Alternatives to Tamoxifen.

Phytoestrogens can be our friends, but know that herbs are powerful. I have no concerns with food-based phytos, but do take care with extracts. They are best rotated so as to maximize benefits, reduce the chances of resistance, and avoid interactions. Drugs, of course, are often even more dangerous, yet are routinely prescribed.

                               Trust me, I’m a doctor” Peter Gøtsche

I interviewed Peter Gøtsche, author of Deadly Medicines and Organised Crime, on my radio show a few years back. Amazing man, whose controversial views have since gotten him tossed from the Cochrane Collaboration, which he co-founded. Sadly, there are many who wish to silence the voices who speak against Big Pharma.

Like me, Gøtsche worries that most people let their doctors make the decisions for them, but the evidence tells us that we should be cautious. He is a strong advocate for the avoidance of drugs and while not against medical interventions, believes one can not just blindly follow the orders of the medical community.

Notably, there is tremendous variability in the metabolic processing of phytoestrogens and pharmacological drugs, thus establishing the difficulty and complexity of this topic. The bottom line is that it extremely important that one understand that it may not make logical sense to attempt to poison one’s way back to health. Certainly drug therapies have worked for many. That said, NO ONE was every born tamoxifen or AI deficient, but over time we may become estrogen dominant, increasing our risk for cancer. It behooves us all to do our research and decide for ourselves whether drugs or holistic remedies are best, or even a combination of both.  

Estrogen plays many important roles in humans, so it may not make sense to arbitrarily take it away. If you are estrogen dominant (meaning out of balance with progesterone), you may want to consider a bio-identical progesterone cream (I like that one as it is paraben-free, soy-free, and Non GMO).

Read Part I of this article HERE.

Reminder: To get an additional $30 off on the online course for breast cancer,  Toxic Free Me, enroll now and use this LINK. This course will further delve into alternatives for anti-hormonal therapies.

An online course not right for you? Know that I am always there for individual consultations.  To inquire about a consult, please visit me HERE.

Life is a journey, just be sure that journey is on-course for a healthy life.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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[i] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; Notably, there are numerous  crsos-references cited in this article that support the use of phytoestogens as nutraceutical anti-hormone therapies for various cancers.

[ii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[iii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/

[iv] https://www.ncbi.nlm.nih.gov/pubmed/27194038; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[v] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/#B61-ijms-18-01381; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[vi] https://www.ncbi.nlm.nih.gov/pubmed/8625449

[vii] https://www.ncbi.nlm.nih.gov/pubmed/28396216; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033666/

[viii] https://www.ncbi.nlm.nih.gov/pubmed/26771497; https://www.ncbi.nlm.nih.gov/pubmed/25408199

[ix] https://www.ncbi.nlm.nih.gov/pubmed/19578798

[x] https://www.ncbi.nlm.nih.gov/pubmed/21741436

[xi] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203161/#b9

[xii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[xiii] https://www.ncbi.nlm.nih.gov/pubmed/26614455

[xiv] https://elynjacobs.com/2016/02/28/flaxseed-better-than-tamoxifen-for-breast-cancer/; https://www.ncbi.nlm.nih.gov/pubmed/29032105; https://www.ncbi.nlm.nih.gov/pubmed/22136581

 

Pau d’arco for Breast, Prostate, Colon, and Other Cancers

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, antioxidants, Breast Cancer, Cancer, Cancer Coach, chemotherapy, CLA and Cancer, colon cancer, Epstein-Barr Virus, Estrogen, Estrogen and Breast Cancer, foods that target cancer stem cells, Healing Cancer Naturally, inflammation, prostate cancer, SERMS, supplements that target cancer stem cells, Tamoxifen, Uncategorized on November 1, 2019 at 8:56 am

Pau d’arco, also known as Taheebo, is extracted from the inner bark of several species of Tabebuia trees that grow in Central and South America. The medicinal uses of Pau d’arco (PDA) date back to 1873.  PDA has been used in South America to treat a wide range of conditions, including pain, ulcers, arthritis, fever, prostatitis, Candida, osteoarthritis, cough, influenza, herpes, diabetes, ulcers, warts, infections, allergies, and even cancer, particularly cancers of the breast, colon, lung, prostate, and malignant melanoma.

What the Docs Have to Say

Dr. James Duke of the National Institutes of Health (NIH) and Dr. Norman Fransworth of the University of Illinois have reported PDA contains active substances (such as β-lapachone and lapacho) found to be highly effective against various cancers. Dr Paulo Martin, a Brazilian medical researcher, reported that PDA has powerful antibiotic, virus and cancer-killing properties.[i] The late integrative oncologist Dr. Mitch Gaynor also used Pau d’arco with his cancer patients.

What the Studies Say

Scientists have discovered that compounds in PDA called naphthoquinones (mainly lapachol and beta-lapachone) are the reason for these impressive healing abilities. PDA also contains a significant amount of the antioxidant quercetin, which has been found to inhibit growth of cancer cells, including cancer stem cells. Some of the exciting cancer research on PDA:

  • Exhibits selective anti-proliferative effects in carcinoma cell lines, including ER+MCF-7 breast cancer cells[ii]
  • Inhibits the growth of estrogen receptor positive breast cancer cells and activates cancer-fighting genes[iii]
  • May block estrogen receptors [much like the SERM tamoxifen] as it is a powerful phytoestrogen [iv]
  • Effective against some bacteria, fungi, viruses (including Epstein Barr), and parasites that may be involved in cancerous processes
  • Induces cell death in prostate cancer lines[v]
  • Induces apoptosis independent of P53 expression; notably, over-expression of bcl2, a contributor for a number of cancers – including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, does not appear to inhibit the  B-lapachone in PDA[vi]
  • Inhibits angiogenesis, the ability of tumors to make new blood vessels in prostate and other cancers[vii]
  • Suppresses the growth and angiogenesis of lung cancer[viii]
  • Inhibits the growth of cancer in a wide range of cancers, such as breast, prostate, cervical, liver, lung, and colon* (see Quercetin below)
  • Appears to increase the effectiveness of chemo and decreases side effects

Research also shows that the lapachol in PDA may have the ability to stimulate the production of red blood cells in bone marrow, which could be helpful for those with low red blood cell counts (RBC). Pau d’arco is also thought to eliminate toxins in the body and purify the blood.

Enjoy Pau d’arco tea, tincture or capsules. Another good tincture is Pau D’ Arco Plus, which also contains dandelion and red clover. Use of PDA during pregnancy is not advised. A potent herb, PDA should be cycled – meaning a few weeks on and then take a break for a few weeks – or swapped out for another cancer-fighting herb. This is especially important for those taking drugs or herbs that thin the blood or for Candida, as resistant strains of Candida can develop.

Please also read my related published articles:

*Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment  Contains a discussion on the powerful anticancer effects of quercetin.

Etiology of Chronic Disease: A Discussion on Epstein-Barr Virus

Spotlight on CLA, a Cancer-Fighting Fatty Acid: CLA (Conjugated Linoleic Acid) is a fatty acid found in grass-fed meats and dairy products, but can also be taken in supplement form.  CLA suppresses the development of cancer at various levels. CLA has been shown to decrease skin, liver, and colon cancer. Activating protein-1 (AP-1) is one of the main promoters of colon and breast cancer, but it is blocked by CLA (licorice root and rosemary-fresh or essential oil also do this). Human abdominal, breast, and axillary fat have the ability to convert androgens into estrogens. Some studies show CLA helps rid the body of belly fat and may modulate immune and inflammatory responses.

To get an additional $30 off on the Online Course for Breast Cancer, Toxic Free Me, enroll now and use this LINK.

Additional Resources for this article:

In your good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

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[i] https://books.google.com/books?id=RIydBQAAQBAJ&pg=PA120&lpg=PA120&dq=dr+norman+farnsworth+pau+d%27arco&source=bl&ots=ZqFrjj9sQr&sig=

[ii] https://www.ncbi.nlm.nih.gov/pubmed/19578798; https://www.ncbi.nlm.nih.gov/pubmed/25891355

[iii] https://www.ncbi.nlm.nih.gov/pubmed/19578798

[iv]  http://www.ndhealthfacts.org/wiki/Phytoestrogen

[v] https://cancerres.aacrjournals.org/content/55/17/3712.short; https://www.ncbi.nlm.nih.gov/pubmed/27048660; http://www.ucdenver.edu/academics/colleges/pharmacy/currentstudents/OnCampusPharmDStudents/ExperientialProgram/Documents/nutr_monographs/Monograph-pau_darco.pdf

[vi] https://cancerres.aacrjournals.org/content/55/17/3712.short

[vii] https://www.ncbi.nlm.nih.gov/pubmed/27048660

[viii] https://www.ncbi.nlm.nih.gov/pubmed/27048660

What You Need to Know About Sugar and Breast Cancer—It’s NOT What You Think!

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, aromatase inhibitors, Boosting Estrogen, Breast Cancer, Cancer, Estrogen and Breast Cancer, Hormone Balance, SERMS, Tamoxifen, Uncategorized on October 20, 2019 at 7:00 pm

Cancer loves sugar, we all know that – sugar feeds cancer and suppresses the immune system. The effects of each dose can last for 5-6 hours. The more sugar we eat, the faster cancer cells can grow. But do you know why sugar happens to love breast cancer?

Cells require sugar for energy, but it needs help to get into the cells. Insulin is the helper that attaches to and signals cells to absorb sugar from the bloodstream. Food sources that boost insulin production and regulate blood sugar levels include red cabbage, sweet potatoes, fenugreek seeds, curcumin, blueberries, vitamin D, and Ceylon cinnamon (so please continue to eat them). However, consuming sugar (sweets, pasta, and many bread, including whole wheat) raises blood sugar levels quickly. The pancreas responds to this by pumping out insulin to lower blood sugar levels. Over time, this can lead to decreased insulin sensitivity. When this happens, the body begins to ignore the signal to take glucose out of the bloodstream and put it into our cells. This triggers the body to start producing even more insulin. The more insulin, the more circulating estrogen there is to stimulate breast cancer cells.

     Sugar spikes insulin levels. Insulin regulates how much estrogen is available to stimulate breast cells. The more sugar you consume, the higher your circulating estrogen levels.

In the Fall 2019 issue of Breast Cancer Wellness there is an excellent article on sugar and its connection to estrogen, written by Dr Christine Horner, M.D. According to Horner, sugar “attacks a portion of the estrogen cycle, making more estrogen available to attach to the estrogen receptors in breast tissue. Insulin regulates how much of the estrogen in your blood is available to attach to estrogen receptors in your breast tissue. When estrogen travels in the blood, it either travels alone seeking a mate (an estrogen receptor), or it travels with a partner (a protein binder) that prevents it from attaching to an estrogen receptor. Insulin regulates the number of protein binders in the blood. So, the higher your insulin levels are, the fewer the number of protein binders there will be and therefore the more free estrogen that will be available to attach to estrogen receptors.  In other words, when your insulin levels are up, free-estrogen levels are up too. And both of them speed up cell division. That’s why high insulin levels increase your risk of breast cancer so much.” She further explains that “when insulin attaches to its receptor, it has the same effect as when estrogen attaches to its receptor; it causes cells to start dividing. The higher your insulin levels are, the faster your breast cells will divide; the faster they divide, the higher your risk of breast cancer is and the faster any existing cancer cells will grow.”

Addressing Estrogen Receptors with SERMS

To address estrogen receptor positive cancers, oncologists often recommend SERMS (selective receptor modulators) such as tamoxifen. However, tamoxifen is a carcinogenic drug that comes with significant side effects, including an increased risk of cancer.

Research shows that phytoestrogens,  plant-derived estrogens that can actually cause anti-estrogenic effects by binding to estrogen receptors (much like tamoxifen), might be worthy of consideration. The potential effects of dietary phytoestrogens have been studied to lower the risk of menopausal symptoms, cardiovascular disease, obesity, metabolic syndrome and type 2 diabetes, brain function disorders, and cancers of the breast, ovaries, endometrium, prostate, and other cancers

I will address the role of phytoestrogens as holistic selective estrogen receptor modulators (SERMS vs Tamoxifen) in a subsequent post.  I will also address the question of ‘do aromatase inhibitors actually increase your risk of breast or other cancers?’. Meanwhile, you may wish to read my many articles on natural alternatives to anti-hormone therapies such as aromatase inhibitors and tamoxifen.

In your good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150resElyn Jacobs is a holistic cancer strategist and speaker specializing in the prevention and treatment of cancer. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

Follow Elyn on Facebook

Follow Elyn on LinkedIn

[i] https://www.sciencedaily.com/releases/2019/02/190212162216.htm