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Male Infertility on the Rise from Cell Phone Use and Environmental Toxins

In antioxidants, Cell Phones, EMF's, EMFs and Health Risks, Fertility and Sperm Counts, infertility, inflammation, male infertility, Radiation, Uncategorized on November 18, 2019 at 8:39 am

It is impossible to envision a guy today who does not use a cellphone, laptop, or other device with Wi-Fi function. We know that these devises lead to the development of several types of cancer, but did you know that they can also impact fertility? Did you also know that endocrine disruptors such as bisphenol A (BPA) and phthalates can compromise male fertility?

What used to be mostly a female issue, fertility has now become a crisis for men as well. Some studies show it is a factor in 30-40% of infertility issues. While men create millions of new sperm daily, it is the quality of sperm that is at risk. To fertilize an egg, a man needs to be able to make healthy sperm and deliver it.

Sadly, the quality of sperm has diminished greatly in the past. A joint study done by Hebrew University and Mount Sinai medical school found that sperm counts have fallen by more than 50 percent in the last 40 years. What that means is that men are almost have as fertile as their grandfathers were.

The issue is complicated as there could be many underlying causes of declining sperm counts. Cell phones, smoking, alcohol consumption, oral contraceptives (contaminating tap water), and endocrine disruptors such as BPA, and phthalates are some of the most common.

Researchers performed at the Department of Obstetrics and Gynecology and Women’s Health, Division of Reproductive Endocrinology and Infertility, Albert Einstein College of Medicine and Montefiore Medical Center, agree that isolating cell phone EMFs from other environmental factors will be a challenge going forward for infertility doctors and their patients. (Incidentally, they too acknowledge that the EMFs can enhance the excitability of the brain and have been classified as carcinogenic).[i]

Modern life could be the answer to the question of fertility — cell phone use, obesity, alcohol consumption, smoking, inactivity, stress, and environmental toxins all play a role.  A 2013 study found that 20 hours of TV [or computer games] weekly may reduce sperm count by a whopping 50%, while 15 or more hours of moderate to vigorous exercise weekly may boost sperm count.[ii]

But of all of these, the hardest to deal with, are EMFs from various devices and exposures and toxins in the environment –specifically endocrine-disrupting chemicals found in things such as BPA and phthalates.

BPA and Phthalates

Chemicals such as BPA  mimic estrogen and can interfere with hormones such as testosterone. Found in plastics, paper products, and cash register receipts, BPA may be rewiring the male reproductive system, eroding sperm quality and quantity and even contributing to testicular disorders.

While not as detrimental to sperm as BPA, phthalates are also a problem. A review of various studies by the National Institute of Public Health confirmed “that phthalates cause diminished sperm count, increased frequency of abnormal spermatozoa and DNA damage in germ cells, especially after chronic exposure.”[iii]

EMFs 

Some of the Research on Cell Phone and Infertility:

  • In 2008, researchers at the Cleveland Clinic found that the use of cell phones by men is associated with decreased fertility. The researchers found a decrease in sperm count, motility, viability, and morphology, all of which impact fertility.[iv]
  • 2010 research by the Department of Physiology, College of Medicine, King Saud University determined “that long-term exposure to mobile phone radiation leads to reduction in serum testosterone levels. Testosterone is a primary male gender hormone and any change in the normal levels may be devastating for reproductive and general health.”[v]
  • In 2012, Dr. Devra Davis, PhD, MPH and author of Disconnect: The Truth about Cell Phone Radiation, What the Industry Has Done to Hide It, and How to Protect Your Family, spoke at the Integrative healthcare Symposium in NYC. She shocked all of us, including doctors and nurses, with evidence-based information regarding the dangers of cellphone on male fertility and various cancers. (Notably, her book was sold out at the conference). She commented that in Israel, there were signs over the urinals suggesting that men take their phones out of their pockets to protect future generations. For more on EMFs from the conference, read my recap. 
  • For Disconnect, Davis interviewed numerous top researchers in the field, including Om P. Gandhi, who studied how cell phones affect the brain, and Franz Adlkofer, who studied how it affects DNA. She also pointed out that men who keep cell phones turned on in their pockets for hours a day have fewer sperm with more deformities. Davis  referenced the work of Harvard trained Ashok Agarwal, who has written more than four hundred peer-reviewed articles. He found that men with the lowest sperm counts were significantly more likely to keep their phones on their bodies all the time, usually in their pockets. He also reported that those who reported using a phone for four hours or more had the lowest and sickliest sperm counts, and that sperm exposed to the highest levels of cell phone radiation had the most deformities and the worst swimming abilities.
  • 2014 research found a direct correlation between cell phone radiation exposure, decreased sperm motility and DNA-fragmentation.[vi] DNA fragmentation within sperm can increase the risk of failed conception or miscarriage. Decreased sperm motility inhibits the ability of sperm to move and ‘swim’ property toward and egg. Decreased morphology refers to the size and shape of sperm. As morphology declines or deteriorates, there is less opportunity to fertilize an egg. The researchers recommend that one avoid holding a mobile device in one’s pants pocket. It only makes sense to keep one’s laptop off their lap.
  • Another 2014 study published in Progress in Biological Sciences commented that EMFs can damage sex organs and cause hormonal disorders. The confirmed that microwave radiation affects various tissues via induction of heat generation and temperature rise, particularly problematic for males as the testes are more temperature sensitive.[vii]
  • 2015 research published in the Asian Pacific Journal of Reproduction determined that low frequency electromagnetic fields long-term exposure significantly reduces sperm motility and testosterone levels.[viii]
  • 2018 research concluded that EMFs may induce oxidative stress with an increased level of reactive oxygen species, which may negatively affect sperm quality and may lead to infertility.[ix]

 Reducing Cell Phone Risk

As evidence mounts for the danger cellphone usage to the brain, many men have resorted to using radiation-free headsets with their phones stored in their pockets.  This is not a good idea, raising concerns of equally damaging responses to the gonads. The particular concerns are a focus on apoptosis of reproductive cells, fertility status, and serum reproductive hormones. It certainly raises concerns for cancer risk below the belt.

Clearly, we can take our phones out of our pockets to minimize exposure. When not in use, phones should be turned OFF or on airplane mode. If trying to conceive, avoid saunas and of course, do not place heat-source objects such as cellphone and laptops near your privates. READ MORE HERE.

If you must put your laptop on your lap, find a good radiation shield, or borrow your mates’ radiation-blocking belly blanket (good gift for her once pregnant).

However, food helps and it helps a lot. Eating fresh mint, blueberries, flax seed and other radio-protectors offer some protection. Supplements can also be helpful. Mixed tocopherols (such as those found in the right kind of vitamin E), carotenoids, melatonin, vitamin C, NAC, curcumin, resveratrol, and flavonoids such as soy, astragalus, apigenin, and propolis have been found to interrupt the inflammatory cascade initiated by EMFs and cellular radiation exposure. (For brand recommendations, click on the highlighted supplement).

For more radio-protectors, please read: Simple Solutions for EMF Radiation Protection

lambs 2Protect your privates. A company called Lambs makes boxer briefs with something they call WaveStopper, a silver-lining technology that apparently blocks 99% of cellphone and WiFi radiation. For a 15% discount on Lambs radio-protective underwear, use this LINK and the code ElynJacobs. For more radio-protective recommendations, please read my articles on 5G and radio-protectors.

Reducing Exposure to Endocrine Disruptors Such as BPA

Use glass for storage instead of plastic dishes and plastic wrap. Do not touch cash register receipts. Use non-toxic cleaning and personal care items.

Detox plastics every day. Eat one or two servings daily of cruciferous vegetables (such as broccoli, kale, arugula, Brussels sprouts) as they speed up detoxification. Supplements such as Indolplex and calcium d’ glucarate give detox an extra boost.

Beware of BPA-Free plastics. Importantly, bisphenol S (BPS) and bisphenol F (BPF) are often used as a replacement for BPA, but so far studies show that they also significantly reduce testosterone levels.[x]

It is also wise to limit take-out food orders which are typically packaged in plastic dishes or in pizza boxes lined with PFAS, harmful chemicals found in non-stick cookware, fire retardants, dental floss, furniture, and water-proof and fire-protective clothing.

Read more about ways to avoid BPA HERE.

Your Health at Risk

An article written by Bryan Walsh, published in Newsweek, Male Infertility Crisis in U.S. Has Experts Baffled, presented powerful information on the topic of male fertility. Walsh detailed the various lifestyle choices and environmental toxins such as BPA that are dramatically reducing sperm counts. The eerie thing is that it appears that low sperm counts may lead to premature death, even among men in the prime of their lives who might seem otherwise healthy.

He quoted Hagai Levine, researcher at the Hebrew University and former chief epidemiologist for the Israel Defense Forces, “The constant production of new sperm cells makes semen highly sensitive to toxins and disease, making it an ideal surrogate for male health—’like blood pressure,’ as Louis puts it—beyond what it might signal for fertility. Poor sperm levels and infertility are a clear sign that men’s health is failing.

One 2015 study found that men diagnosed with infertility have a higher risk of developing health issues like heart disease, diabetes and alcohol abuse, while another connected infertility to cancer. ‘Semen quality isn’t just about a couple getting pregnant,’ says Louis. “There is increasing evidence at the population level that men with diminished semen quality die earlier and have more chronic diseases. This is as important to health as any disease state.

Sperm count decline is the canary in the coal mine says Levine. ‘There is something very wrong in the environment.’ Which means there may be something very wrong with men. “[xii]

While I do agree there is something very wrong in the environment, I don’t agree on the issue of direct increased risk of poor health, or that there is something very wrong with men. It is more likely a reflection of poor lifestyle habits and an accumulation of toxins that are affecting both sperm and overall health. EMFs , phthalates, and BPA clearly pose significant health risks. For example, phthalates deplete zinc, which could lead to conditions such as heart disease, cancer, diabetes, and accelerated aging.

That said, it is important that everyone understands the seriousness of the accumulation of EMFs, plastics, and other toxins in the body. Your health depends on on avoiding and clearing your body of these toxins. I recommend everyone follow a detox protocol and use caution with cell phones and other EMF sources.

What You Can Do Now

  • Don’t smoke or take drugs (even over the counter can affect sperm quality)
  • Limit or avoid alcohol
  • Manage stress
  • Stay active, avoid sitting too long, and maintain a healthy weight
  • Stay cool; avoid saunas, tight clothing, and placing heat-source objects such as cell phones and laptops near your privates
  • Avoid exposure to pesticides, plastics, heavy metals, and other environmental toxins (which includes takeout containers, pizza boxes, and even most dental floss)
  • Eat plenty of cruciferous vegetables (broccoli, cauliflower, radishes, etc), which help to detox plastics
  • Eat a colorful diet, full of fruits and vegetables
  • Consider Indolplex and calcium d’ glucarate, which detox plastic and other toxins (click on the links for brand recommendations)
  • Consider Bee Propolis, which contains the flavonoid chrysin, which is believed to block estrogen and increase testosterone; bee propolis also reduces the inflammatory response from EMF exposure
  • Re-read Simple Solutions for EMF Radiation Protection and the supplement recommendations above

If you are looking forward to having children, I suggest you see your doctor. S/he will likely send you for a semen analysis. However, in order to get an accurate assessment, you may have to repeat the test several times. This can be expensive and time consuming (plus some men are less inclined to visit the doctor for fertility issues). There is an at-home test kit called TRAK, that men can use to evaluate their sperm levels.

Life is a journey, just be sure that journey is on-course for a healthy life.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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[i] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309987/

[ii] https://www.hsph.harvard.edu/news/press-releases/tv-viewing-exercise-habits-may-significantly-affect-sperm-count/

[iii] https://www.ncbi.nlm.nih.gov/pubmed/27546318; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879116/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679188/ (BPA links)

[iv] https://www.ncbi.nlm.nih.gov/pubmed/17482179

[v] https://www.ncbi.nlm.nih.gov/pubmed/20714683

[vi] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074720/

[vii] https://pbiosci.ut.ac.ir/article_50306_42f28ca1fe751b63fc3da41feab4821d.pdf

[viii] https://www.sciencedirect.com/science/article/pii/S2305050015000044

[ix] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240172/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250044/

[x] https://www.fertstert.org/article/S0015-0282(14)02351-6/abstract

[xi] https://www.hsph.harvard.edu/news/press-releases/tv-viewing-exercise-habits-may-significantly-affect-sperm-count/

[xii] https://www.newsweek.com/2017/09/22/male-infertility-crisis-experts-663074.html

Could the Natural Alternative to Tamoxifen and Aromatase Inhibitors be in Your Refrigerator? Part II

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, antioxidants, aromatase inhibitors, BPA and breast cancer, Breast Cancer, Cancer, Cancer Coach, cancer stem cells and recurrence, Estrogen, Estrogen and Breast Cancer, Natural Aromatase Inhibitors, prostate cancer, SERMS, Tamoxifen, Uncategorized on November 15, 2019 at 9:07 am

Synthetic selective estrogen receptor modulators (SERMS) such as tamoxifen and pharmaceutical aromatase inhibitors are often recommended for ER+ breast and other hormone-driven cancers, but they have significant adverse effects. Is it possible that natural plant products can perform the same function without the risks and damage of pharmaceuticals? Research says they can.

While estrogen plays many important beneficial roles in humans, the proliferation of ER+ breast cancer cells can sometimes be enhanced by estrogen (especially in the absence of progesterone), which may induce multiple processes involved in cell survival and cell cycle progression. Beyond the estrogen dominance that comes from a lack of progesterone, it is not necessarily our own estrogen at fault, but more likely xenoestrogens — the chemical estrogens, environmental hazards such as BPA and BPS — Bisphenol A and S.

However, to add clarity to the estrogen equation that oncologists speak of, the body has two different estrogen receptors, ERα (alpha) and ERβ (beta). ERα has a proliferative effect, and ERβ acts as a negative regulator of ERα in breast cancer cells, counteracting the proliferative effect of estrogens. Importantly, plant estrogens (phytoestrogens) preferentially interact with ERβ and display high specificity toward ERβ transactivation. Phytoestrogens, also known as phytochemicals, are synthesized from plants and vegetables. They show low estrogenic activity or anti-estrogenic activity with anti-proliferative effects that studies show offer nutraceutical alternatives to pharmaceutical anti-hormone therapies for various cancers.[ii]

For the men reading this article (including those with breast cancer), androgens and estrogens also influence the development and progression of prostate cancer. Research shows that phytoestrogens such as soy could be used alone or in conjunction with anti-hormone therapies for prostate cancer to target metabolic pathways involved in androgen and estrogen syntheses and epigenetic modifications of DNA to promote tumor-suppressor genes.[iv]

In a nutshell, phytoestrogens may be useful as substitutes for breast cancer treatments such as tamoxifen or aromatase inhibitors, and could be extremely helpful for other hormone-related cancers.

The Role of Phytoestrogens as Replacements for SERMs and Aromatase Inhibitors

It is well-established that many foods and natural products have beneficial effects on ER+ breast cancer as well as other hormone-driven cancers.  Pytoestrogens are structurally similar to our own estrogen, but functionally are weakly estrogenic (weakly mimicking estrogen) or antiestrogenic (blocking estrogens’ effects). They have been researched extensively for their role in the interaction with estrogen receptors. The beauty is that they block the receptors from more volatile estrogens.  As such, they deserve consideration in preventive and therapeutic settings for the intervention of cancer initiation and progression.

Studies show that phytoestrogens may provide an alternative or complementary approach to anti-hormone treatments. For example, 2017 research published in the International Journal of Molecular Sciences cited many studies confirming that an important application of phytoestrogens is that they could be used as an alternative to the SERMs.[iii] In general, phytoestrogens act as aromatase inhibitors by decreasing aromatase gene expression and inhibiting the aromatase enzyme.   

Some of the more powerful phytoestrogens include flax and sesame seeds as well as whole soy. 

Flax and sesame seeds have anticancer, breast tumor-reducing effects. Both lignans are metabolized to estrogen-like enterodiol and enterolactone, and reduce cell proliferation and apoptosis.[xiv] While each works a bit differently, both may be useful as an effective adjuvant therapeutic agent against tumor development and progression, and therefore, could be used in the prevention and/or treatment of various types of cancer. Studies show that higher intakes of lignans such as flax and sesame seeds are associated with a reduced risk of breast cancer. Flax seed works with tamoxifen to inhibit breast cancer tumor growth, so if you choose to take tamoxifen, know that you can also benefit from flax.  

I have written extensively on the benefits of flax seed, but to recap, a few of the benefits of flax are the following:

  • Decreases cell proliferation rates and inhibits tumor growth in ER+ cancers
  • Decreases angiogenesis (blood supply for tumors) and increases apoptosis (cancer cell death)
  • Influences ER-negative and ER-positive tumors by decreasing insulin-like growth factor-1 (IGF-1), epidermal growth factor receptor (EGFR), HER2 and the vascular endothelial growth factor (VEGF) which supports angiogenesis
  • Reduces growth and metastasis of ER-negative and triple negative breast cancers
  • Favorably influences tumor suppressor genes

For more on flax seed and breast cancer, please read some of my other posts, such as  Demystifying Flaxseed and Estrogen and Flaxseed, Better Than Tamoxifen for Breast Cancer.

Soy: Numerous studies indicate that genistein, the most abundant isoflavone present in soybeans, has anti-proliferative effects on various cancer cells, including prostate, ovarian, and breast. Like other phytoestrogens, genistein interferes with the effects of estradiol by binding to estrogen receptors. This is good as soy may also inhibit inflammation and boost anticancer immune responses, while other estrogens do not. The following are a few key findings of soy[v]:

  • Inhibits NF-kB activity in prostate, breast, lung, and pancreatic cancer cells. Nf-kB plays a crucial role in immune response, inflammation, cell growth and survival.
  • Selective tyrosine kinase inhibitor impeding angiogenesis, a major factor in cancer growth and proliferation. Tyrosine kinases play important roles in cell proliferation, survival, migration and differentiation are often altered in cancer cells, leading to malignancy
  • Induces cancer cell death (apoptosis) in several cancer cell lines, including prostate, ovarian, and breast cancer
  • Modulates EGF (epidermal growth factor) which has been implicated in the development and growth of many types of cancer cells
  • Long-term consumption seems to result in a decreased response to stimulation by estradiol[vi]

Please note that soy consumption is somewhat controversial. Please work with your coach or medical professional to see if soy consumption is right for you.

More Notable Phytoestrogens                                                                            parsley root

  • Apigenin is a natural flavonoid commonly found in fruits and vegetables such as parsley, celery, thyme, chamomile tea, and oranges. The chemical structure of apigenin is similar to estrogen and as such it mimics estrogen. 2107 research indicates that phytoestrogens such as apigenin and resveratrol have the therapeutic potential act like SERMs and could be considered in the development of therapeutics for breast cancer and brain disease.[vii] Extensive studies show that apigenin has potent antioxidant and anticancer activities in ER-positive and ER-negative breast cancer. Apigenin also inhibits proteasome, which certain cancer cells need for survival. By inhibiting proteasome, phytoestrogens such as apigenin induce apoptosis in prostate, breast, and many other cancer cell lines.[viii]
  • Pau d’ Arco exhibits selective anti-proliferative effects in carcinoma cell lines. A study performed at the Strang Cancer Prevention Center in New York found that the anti-proliferative effects of herbal medicines such as pau d’arco may correlate with down-regulated estrogen responsive genes and up-regulated apoptosis-specific genes. The researchers believe their data validates the need to prioritize efficacious herbal medicines and concluded that phytoestrogens such as pau d’arco may provide an alternative or complementary approach to endocrine therapy for breast cancer.[ix] Read more
  • Broccoli: The sulforaphane in broccoli (particularly in broccoli seeds and sprouts) has been found to inhibit proliferation and down-regulates hormone receptor expression in MCF-7 cells. Sulforaphane also passes the blood brain barrier and targets cancer stem cells. If you cannot find sprouts locally, I recommend a supplement.sprouts
  • Luteolin and Naringenin: Flavonoids, especially flavones such as luteolin and flavanones such as naringenin are potent aromatase inhibitors. [x] Luteolin has also been found to down-regulate aromatase gene expression. Luteolin is found in celery, thyme and chamomile tea. Some rich sources of naringenin include bergamot, grapefruit, tomatoes, and tart cherries.
  • Quercetin, found in abundance in food sources such as apples, onions, tea, and red wine, has been reported to have strong antioxidant, anti-inflammatory, antiviral, and anticancer effects. It has the ability bind at high affinity to estrogen receptors, resulting in inhibition of estrogen-regulated cell growth and proliferation[xi]
  • Hesperetin, found in citrus fruits and essentials oils, exerts it anticancer actions by inhibiting cell proliferation, inducing apoptosis, and by regulating aromatase activity and oxidative stress. Although hesperetin is unable to bind to ERs, it is effective in inhibiting cell proliferation of ER+ breast cancer and dramatically decreasing tumor size and other actions. Hesperetin has also been found to reduce serum estrogen levels and down-regulate estrogen target genes and estrogen metabolism-related genes.[xii]. Try putting a drop or two of lemon essential oil in your water, or grating the peel of an organic lemon.
  • Black seed contains thymoquinone, a phytochemical compound found in plant Nigella sativa. It has been found to initiate apoptosis, improve estrogen metabolism, and regulate signally pathways in breast cancer.
  • Vitamin E inhibits cell proliferation, down-regulates the expression of ERα, ERβ, COX-2, and serum estrogen levels (should always be mixed tocopherols, not just d-alpha.
  • Red Clover binds to estrogen receptors, inhibits cell proliferation, and initiates apoptosis in ER+ breast cancer cells.
  • Ellagic acid, a dietary flavonoid present in berries, grapes, pomegranates, and nuts, inhibits cell proliferation and promotes apoptosis in ER+ breast cancer cells.
  • Eugenol, a compound found in clove oil, inhibits cell proliferation and initiates cancer cell death in both ER+ and ER- breast cancers. Excitingly, one study done in Indonesia found that eugenol  is a potent ERa antagonist. The researchers indicate that not only does it work just like tamoxifen, but it may actually work even better.
  • This list is  not inclusive: There are many more powerful phytoestrogens. For more cancer-fighting alternatives to pharmaceuticals, please read my articles on Natural Alternatives to Aromatase Inhibitors and Natural Alternatives to Tamoxifen.

Phytoestrogens can be our friends, but know that herbs are powerful. I have no concerns with food-based phytos, but do take care with extracts. They are best rotated so as to maximize benefits, reduce the chances of resistance, and avoid interactions. Drugs, of course, are often even more dangerous, yet are routinely prescribed.

                               Trust me, I’m a doctor” Peter Gøtsche

I interviewed Peter Gøtsche, author of Deadly Medicines and Organised Crime, on my radio show a few years back. Amazing man, whose controversial views have since gotten him tossed from the Cochrane Collaboration, which he co-founded. Sadly, there are many who wish to silence the voices who speak against Big Pharma.

Like me, Gøtsche worries that most people let their doctors make the decisions for them, but the evidence tells us that we should be cautious. He is a strong advocate for the avoidance of drugs and while not against medical interventions, believes one can not just blindly follow the orders of the medical community.

Notably, there is tremendous variability in the metabolic processing of phytoestrogens and pharmacological drugs, thus establishing the difficulty and complexity of this topic. The bottom line is that it extremely important that one understand that it may not make logical sense to attempt to poison one’s way back to health. Certainly drug therapies have worked for many. That said, NO ONE was every born tamoxifen or AI deficient, but over time we may become estrogen dominant, increasing our risk for cancer. It behooves us all to do our research and decide for ourselves whether drugs or holistic remedies are best, or even a combination of both.  

Estrogen plays many important roles in humans, so it may not make sense to arbitrarily take it away. If you are estrogen dominant (meaning out of balance with progesterone), you may want to consider a bio-identical progesterone cream (I like that one as it is paraben-free, soy-free, and Non GMO).

Read Part I of this article HERE.

Reminder: To get an additional $30 off on the online course for breast cancer,  Toxic Free Me, enroll now and use this LINK. This course will further delve into alternatives for anti-hormonal therapies.

An online course not right for you? Know that I am always there for individual consultations.  To inquire about a consult, please visit me HERE.

Life is a journey, just be sure that journey is on-course for a healthy life.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

Affiliate Links Disclosure:

Some product links on some posts are affiliate links. This website is monetized in part through the use of affiliate links. This means that if you were to click on a link that is an affiliate link and purchase an item after clicking on that link, I may receive a small percentage of the sales price. I only recommend products that I love and use often. Thank you for your support!

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[i] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; Notably, there are numerous  crsos-references cited in this article that support the use of phytoestogens as nutraceutical anti-hormone therapies for various cancers.

[ii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[iii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/

[iv] https://www.ncbi.nlm.nih.gov/pubmed/27194038; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[v] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/#B61-ijms-18-01381; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874/

[vi] https://www.ncbi.nlm.nih.gov/pubmed/8625449

[vii] https://www.ncbi.nlm.nih.gov/pubmed/28396216; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033666/

[viii] https://www.ncbi.nlm.nih.gov/pubmed/26771497; https://www.ncbi.nlm.nih.gov/pubmed/25408199

[ix] https://www.ncbi.nlm.nih.gov/pubmed/19578798

[x] https://www.ncbi.nlm.nih.gov/pubmed/21741436

[xi] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203161/#b9

[xii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535874

[xiii] https://www.ncbi.nlm.nih.gov/pubmed/26614455

[xiv] https://elynjacobs.com/2016/02/28/flaxseed-better-than-tamoxifen-for-breast-cancer/; https://www.ncbi.nlm.nih.gov/pubmed/29032105; https://www.ncbi.nlm.nih.gov/pubmed/22136581

 

Could the Natural Alternative to Tamoxifen and Aromatase Inhibitors be in Your Refrigerator? Part I

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Alternatives to Anti-Hormone Therapy For Breast Cancer, Alternatives to Hormone Therapy for Breast Cancer, Alternatives to Tamoxifen, Anticancer foods, foods for colon cancer, foods for breast cancer, aromatase inhibitors, Breast Cancer, Cancer, Cancer Coach, Emotional Healing, Estrogen, Estrogen and Breast Cancer, Uncategorized on November 14, 2019 at 9:59 am

Estrogen play an important role in overall health in humans—it protects your heart, lungs, eyes, brain, bones, skin, and hair, averts cognitive decline, and does so much more. Estrogen is also protective against adverse symptoms during the peri-and postmenopausal periods. But estrogens are known to stimulate cellular proliferation associated with certain cancers. Hence, if you have been diagnosed with a hormone-related cancer, your doctor may advise a synthetic selective estrogen receptor modulator (SERM) such as tamoxifen or a pharmaceutical aromatase inhibitor such as Femara (letrozole), Arimidex (anastrozole), or Aromasin (exemestane).

Of course, these pharmaceutical drugs come with a host of detrimental side effects. What’s a person to do?

Side Effects and Resulting Effects of Pharmaceutical Anti-Hormone Drugs

pills tamoxifenSome side effects of tamoxifen include severe muscle pain, weight gain, thickening of endometrial lining of the uterus, daytime sleepiness, nausea, edema, hot flashes, vaginal hemorrhage, increased risk of cataracts, acute glaucoma, and other eye issues. It is not recommended to take tamoxifen if you have impaired CYP2D6 enzyme, nor should you take medications that block the activity of CYP2D6, such as Benadryl, Prozac, Paxil, and Zoloft (these lists are not inclusive) during treatment. Tamoxifen has been declared a human carcinogen by the WHO, NIH and other authorities.

Side effects of aromatase inhibitors include damage to the heart, never-ending flu-like symptoms, hair thinning and loss, joint pain, stiffness and swelling, hot flashes, vaginal dryness, and headaches, a feeling of tiredness and lethargy, difficulty breathing, nails breaking down and peeling, memory fog, depression and mood swings, balance problems, sleep disorders, tightness of the chest, bone thinning, and more.

In the summer edition of Cure magazine, they spoke of a doctor who when asked why he didn’t tell his patient about the side effects of the prescribed hormonal therapy, replied “some women would not take the pill if they knew bout the side effects”. Incidentally, these were not listed on the medical paper that came with her bill.

Clinical trials have indicated that resistance develops with both tamoxifen and aromatase inhibitors. This is another major pharmaceutical problem and cause of serious concern to clinicians and patients.

So, again what exactly is a person to do?

The easiest and most logical answer is to eat copious amounts of phytoestrogens throughout the day.

Phytoestrogens are plant-derived naturally occurring compounds that have chemical structures similar to estrogens. Phytoestrogens have been found to decrease cancer risk by inhibiting aromatase activity and CYP19 gene expression (The aromatase enzyme is a product of the CYP19A1 gene).

Aromatase plays an important role in breast cancer as it converts androgens to estrogens in many human tissues, the result of which has been known to stimulate cellular proliferation in certain cancers. In the vast majority of breast cancers, estrogen levels play a role tumor growth and depend on the activity of CYP19.

Research performed in 2015 by the Department of Physiology and Developmental Biology and The Neuroscience Center at Brigham Young University, indicates that phytoestrogens act as aromatase inhibitors by decreasing aromatase gene expression and inhibiting the aromatase enzyme. Their findings emphasize that estrogens have a significant impact on health and that phytoestrogens (being of similar structure to 17β-estradiol) have strong potential as anticancer agents.[i]

The researchers concluded that phytoestrogens not only act as SERMs (as has been previously reported and I will get into in Part II of this post), but also have the ability to alter the activity of the aromatase enzyme. They go on to remind us that the inhibition of aromatase activity and gene expression represents a key mechanism of how phytoestrogens may contribute to decreased cancer risk and recurrence.

The important difference is that phytoestrogens do not initiate the cascade of negative effects of pharmaceutical drugs and as estrogen modulators, may stave off the negative effects of declining estrogen, making them effective in more ways than one. Further, unlike drugs, they offer significant cancer-fighting abilities. For example, the apigenin in parsley is known not only for its aromatase-inhibiting abilities, but also for promoting cancer cell death, including cancer stem cells. parsley

In Part II of this post I will discuss many different phytoestrogens—all of which play a significant roll in the management of hormone-related cancers. In the meantime, a few of my favorites are flax and sesame seeds, broccoli sprouts, including the seeds (sulforaphane), parsley (apigenin), and organic whole soy.

However, as a strong reminder, estrogen is not the biggest driver of cancer, at least not your own estrogen. Emotional and environmental toxins (including xenoestrogens such as BPA and BPS) are often at the root of it all, as well as the viral factor—it is imperative that you resolve these issues as well as anything that may have contributed to your cancerous environment.

Importantly, it is not always wise or even necessary to reduce estrogen (many post-menopausal women already suffer from low estrogen). This is especially true for very thin women as post-menopause, estrogen is no longer made in the ovaries, but rather from adipose tissue (fat, especially in the breasts and belly), of which they may have very little. (This is also why many doctors advise their patients to lose weight, if necessary). Thin women might benefit more by raising progesterone. Reminder that you have to be very careful with compounded bio-identicals; read more HERE.

Many of my followers have been asking about a safe  bio-identical progesterone cream (It is paraben-free, soy-free, and Non GMO). 

Read Part II HERE

Below are just some of the articles I have written on natural alternatives to tamoxifen and aromatase inhibitors:

Why You May Want to Reconsider Estrogen-Blocking Aromatase Inhibitors and Tamoxifen

Natural Alternatives to Hormone Therapy for Breast Cancer

What to Do if You Have Low Estrogen Levels and Your Doctor Prescribes an Aromatase Inhibitor

Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment

Managing Estrogen Naturally

Flaxseed, Better than Tamoxifen for Breast Cancer

Flaxseed, the Anticancer Power Seed

Alternatives to Aromatase Inhibitors

 

Reminder: To get an additional $30 off on Marnie Clarks’ online course for breast cancer,  Toxic Free Me, enroll now and use this LINK. This course will also delve into alternatives for anti-hormonal therapies.

An online course not right for you? Know that I am always there for individual consultations.  To inquire about a consult, please visit me HERE.

Life is a journey, just be sure that journey is on-course for a healthy life.

In your everlasting good health,

Elyn

~~If you don’t know your options, you don’t have any~~

ej portrait 150res for PrueElyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make healthier, less-toxic choices for their healing. She emphasizes the importance of not just surviving cancer, but surviving well and reducing the risk of recurrence. She is a Contributing Editor for The Truth About Cancer and is on the Medical Advisory Board for BeatCancer.Org and the Advisory Board to the Radical Remission Project. Elyn has written for numerous journals and publications. She was the former Executive Director of the Emerald Heart Cancer Foundation and the creator and host of the Survive and Live Well Radio Show. To contact Elyn, visit www.elynjacobs.com. Elyn offers consults via Skype, phone, or in-person. Elyn does not provide online advice.

DISCLAIMER:
Elyn Jacobs does not provide medical advice. The information provided is for general information only. No online site should be used as a substitute for personal medical attention.

This information is for educational purposes only and is not a recommendation to forgo medical advice and treatment.  This post is not intended to treat, cure, prevent, or diagnose any disease or condition. This post does not represent medical advice nor should it be considered to be medical advice or a replacement for medical advice.  I encourage you to discuss this information with your integrative oncologist, naturopathic doctor, or conventional oncologist. The information provided is from my research and not to be taken as scientific evidence.

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[i] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/