Archive for the ‘High Dose Vitamin C and Cancer’ Category

What You Need to Know About Mutations in the p53 Cancer Tumor Suppressor Gene

In Alternative Cancer Therapies, Alternatives Cancer Treatment, Anticancer foods, foods for colon cancer, foods for breast cancer, colon cancer, High Dose Vitamin C and Cancer, Radiation on January 3, 2017 at 2:34 pm

The word mutation just doesn’t sound like something good. By definition, a mutation is a permanent change in DNA. Mutations, for the most part, are harmless except when they lead to tumor formation. 

Likely you have heard about BRCA mutations. BRCA genes are tumor suppressor genes. BRCA mutations can increase one’s risk for cancers of the breast and ovaries. However, these mutations are only responsible for about 5-10% of all breast cancers and about 15% of ovarian cancers. But, the little-known p53 mutation affects far more people. About 50% of all cancers have a mutated p53 gene.

What is P53?
The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. (It is actually the TP53 gene that provides instructions for making the tumor protein p53 but for simplicity, I will say p53.) P53 regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.

P53 plays a critical role in determining whether damaged DNA will be repaired or a damaged cell will self-destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors.

Mutated P53
P53 mutations lead to a version of p53 that cannot regulate cell growth and division effectively. Specifically, the altered protein is unable to trigger apoptosis in cells with mutated or damaged DNA.

DNA can be damaged by agents such as toxic chemicals, radiation such as gamma rays, X-rays — even UV light can interact with compounds in the cell generating free radicals which cause chemical damage to DNA.

Since all cells in our body contain DNA, there are lots of places for mutations such as p53 to occur. When p53 does not operate properly, damaged DNA can replicate, producing mutations and DNA rearrangements that contribute to the development of a highly transformed, metastatic cell. Many cancer cells inactivate p53, allowing the cells to evade death and continue proliferating up to becoming a tumor.

Mutant p53 proteins not only lose their tumor suppressive activities but often escalate the development of cancerous tumors by providing them with growth and survival mechanisms. Interestingly, mutations in the p53 gene have been shown to occur at different phases of the cancer process, contributing to tumor initiation, promotion, aggressiveness, and metastasis.

P53 mutations contribute to risk of brain tumors and breast, prostate, colon and other cancers. Mutations in p53 gene usually correlate with poor outcome and early recurrence in cancer.

Enough of the bad news.

The Good News
What is really exciting is that this repair gene, p53, which protects cells from becoming cancerous, can be highly activated by many natural substances—substances that do not have the negative side effects of drug therapies. The ability to activate p53 within cells may halt cell proliferation, or even cause cancer cell death.


watercressFor example, cruciferous vegetables (especially watercress with its high content of PEITC) have been found to support p53. PEITC (phenethylisothyanate) decreases the levels of mutated p53 and helps to restore the normal activity of this protein. Vitamin C is another promoter of P53, which is one of the reasons intravenous Vitamin C (IVC) and high-dose oral C therapies are so effective against cancer.
The resveratrol in red grapes and red wine (organic please, and research shows dark, red wines are best) also activates the P53 gene. IP6 has been shown to alter the expression of p53. Zinc helps protect the p53 gene against cancer-forming mutations. Selenium can activate p53 in response to genetic damage, helping the cell to repair its DNA. Herbs such as sage, rosemary, ginger, curcumin, and ashwaganda support p53. Thymoquinone extracted from black seed triggers apoptotic cell death in colorectal and other cancers cells via the p53- dependent mechanism. Anthocyanins, abundant in red  onions, inhibit the damage that impaired p53 can cause on cells and tissue. Anthocyanins are also found in blackberries, blueberries, purple grapes, eggplant, and avocado.

P53 Supporters:
• Cruciferous vegetables, especially watercress
• Herbs such as sage, rosemary, ginger, curcumin, and ashwaganda
• EFA’s from omega 3 fatty acids (please use caution with fish oil supplements as they can be toxic). For a plant based formula, you could take BodyBio Balance Oil.
• Licorice
• Mistletoe
Vitamin D
• Vitamin C
Black Seed
Clinoptilolite (a special form of Zeolite)
On the other hand, processed foods, refined flours, and sugars will impair P53. Smokey flavoring and smoked foods can also damage DNA. Chemicals such as benzene and perchloroethylene, two volatile organic compounds, negatively affect p53, possibly causing them to stimulate rather than suppress cell proliferation.

The late Integrative Oncologist Dr Mitchell Gaynor, MD was famous for his passion for explaining that we can change the way our genes behave by making good dietary choices. For more gene-changing foods and lifestyle habits read Dr. Gaynor’s book, The Gene Therapy Plan, Taking Control of Your Genetic Destiny with Diet and Lifestyle.

P53 and BRCA are not the only genetic mutations that increase cancer risk. For example, mutations in th e CHEK2 gene are associated with an increased risk of developing many types of cancer, including breast, colon, prostate, and other cancers — sometimes at young ages. If you have a history of hereditary cancer you might benefit from genetic testing for CHEK2 and others.

You can request to be tested for the p53 mutation. The test is called the p53 Gene Mutation Analysis, Cell Based, offered by labs such as Quest Diagnostics. If your insurance company does not accept Quest or another lab that offers this test, you can petition your carrier for a Network Gap Exception.
You may need to consult a genetic counselor if your oncologist does not routinely check for mutations as these tests are not part of your typical pathology report.

Found this article helpful?  Please let me know.



~~If you don’t know your options, you don’t have any~~

Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

Follow Elyn on Facebook
Follow Elyn on LinkedIn


Must Reads for Every Cancer Patient or Survivor

In Alternative Cancer Therapies, Books for Cancer Patients, Cancer, Healing Cancer Naturally, High Dose Vitamin C and Cancer on November 28, 2016 at 2:23 pm

Right now Amazon is taking $10 off book purchases over $25. Just use the code HOLIDAYBOOK.

My Recommendations:

LifelinesLifelines to Survival: A New Approach to Personalized Care $17.  To read my review of this book, click HERE.

Orthomolecular Medicine for Everyone  A great read for those who value nutrition as good medicine.  You will learn about high-dose vitamin therapies and why they work for many. $15.

childhood-disruptedChildhood Disrupted: How Your Biography Becomes Your Biology, and How You Can Heal. While we cannot change what happened in our childhood, we can alter its effects on us –something most oncologists completely overlook as a critical part of treatment and recovery. Childhood Disrupted also explains how to cope and heal from these emotional traumas. $11. To read my post on this book, click HERE.

Radical Remission: Surviving Cancer Against All Odds $10

Breast cancer booksWaking the Warrior Goddess, Third Edition: Dr. Christine Horner’s Program to Protect Against & Fight Breast Cancer $22

The Whole-Food Guide for Breast Cancer Survivors: A Nutritional Approach to Preventing Recurrence (The New Harbinger Whole-Body Healing Series) $13

Eat Dirt: Why Leaky Gut May Be the Root Cause of Your Health Problems and 5 Surprising Steps to Cure It $17

The Truth about Cancer: What You Need to Know about Cancer’s History, Treatment, and Prevention $15

Essential oils and Cancer  $7

Life Over Cancer: The Block Center Program for Integrative Cancer Treatment $22

The Iodine Crisis: What You Don’t Know About Iodine Can Wreck Your Life $17

gaynor GTPThe Gene Therapy Plan: Taking Control of Your Genetic Destiny with Diet and Lifestyle $14

Beyond the Magic Bullet $30

Beating Cancer With Nutrition  $19

More …

Cancer Report: The Latest Research – How Thousands are Achieving Permanent Recoveries

The Etiology of Breast Cancer: Endogenous and Exogenous Causes

Killing Cancer Not People New 3rd Edition

 You Are the Placebo.  Is it possible to heal by thought alone—without drugs or surgery? The truth is that it happens more often than you might expect. In You Are the Placebo, Dr. Joe Dispenza shares numerous documented cases of those who reversed cancer, heart disease, depression, crippling arthritis, and even the tremors of Parkinson’s disease by believing in a placebo.

The Hidden Connection: Discover What’s Keeping You from Feeling Happy, Healthy and Symptom-Free

Miracle Survivors: Beating the Odds of Incurable Cancer

Cancer Free!Cancer Free, Are You Sure? While many people are comforted by the words “you are cancer free”, it is imperative to know that an all-clear PET or CT is often meaningless.  Read this amazing book to learn more.

 Recommended Cookbooks:

The Oh She Glows Cookbook: Over 100 Vegan Recipes to Glow from the Inside Out

The Cancer-Fighting Kitchen: Nourishing, Big-Flavor Recipes for Cancer Treatment and Recovery

Vegan Richa’s Indian Kitchen: Traditional and Creative Recipes for the Home Cook



High Dose Vitamin C: The Other Cancer Therapy

In Alternative Cancer Therapies, Cancer, Healing Cancer Naturally, High Dose Vitamin C, High Dose Vitamin C and Cancer on September 17, 2016 at 10:17 am

Can Oral High Dose Vitamin C Kill Cancer Cells More Effectively than Intravenous C?

The use of High-Dose Vitamin C for cancer mitigation and management has been studied for years. Holistically minded professions use HDVC in conjunction with other innovative treatments to maximize effectiveness. Most of these doctors do not use traditional chemotherapy or radiation as they often cause permanent or even fatal side effects –these therapies destroy all cells, healthy and malignant, eventually leading to patient death.

Building on the work of Linus Pauling, who was recognized as the world’s foremost advocate of therapeutic vitamin C, significant research shows that high dose vitamin C (HDVC) effectively eradicates cancer cells while leaving healthy cells intact. HDVC has been used alongside cancer therapies (both conventional and holistic) since the 1970’s. While not considered to be a cancer cure, it is a powerful adjunctive therapy for cancer patients.

Ascorbic acid is preferentially toxic to tumor cells suggesting that it could be useful as a chemotherapeutic agent. While again I would not suggest using HDVC as a stand-alone treatment, studies have shown it to kill cancer cells, slow the growth of cancers, and greatly improve the effectiveness of other cancer treatments. Some research shows that HDVC can reduce tumor size and may lead to tumor regression, including in patients with metastatic disease.

 Antioxidant vs Pro-oxidant

At ordinary doses, vitamin C acts as an antioxidant, protecting cells from free radical damage. However, at high doses, it acts like a pro-oxidant drug that produces hydrogen peroxide, which targets cancer cells while leaving normal cells unharmed. Hydrogen peroxide is lethal to cancer cells. It oxidizes the tissues by converting the free radicals into hydrogen peroxide that can destroy the cancer cells and inhibit their energy supply.

According to Dr Steve Hickey, PhD, ” Fortunately within tumors, vitamin C and certain other dietary ‘antioxidants’ act as oxidants, rather than antioxidants.  Morever, the same substances act as antioxidants within healthy cells.  This means they can destroy cancer cells, while simultaneously improving the health of the rest of the body.”

According to the National Institute of Health:

“Many laboratory studies have been done to find out how high-dose vitamin C may cause the death of cancer cells. The anticancer effect of vitamin C in different types of cancer cells involves a chemical reaction that makes hydrogen peroxide, which may kill cancer cells.”

Vitamin C also does more than just kill cancer cells. It boosts immunity which we know is essential for the prevention and management of cancer.

Vitamin C, Immunity, and Cancer: 

  • Increased immune function with enhanced antibody production (lymphocytes)
  • Stimulation of collagen formation necessary to wall off tumors (replacement and destruction of tumor cells)
  • Enhanced natural killer cell activity
  • Inhibits of hyaluronidase to keep ground substance intact and preventing metastases
  • Inhibition of oncogenic viruses
  • Supports the p53 tumor suppressor gene
  • Corrections of C deficiency commonly seen in cancer patients
  • Enhanced healing of surgical wounds
  • Enhanced anticancer effects of certain chemotherapeutic agents
  • Chemotherapy and radiation better tolerated when HDVC is used (including reduced pain)
  • Combining high dose vitamin C with radiation and/or certain types of chemo may be more effective than these treatments on their own
  • Prevents free radical damage by responding to inflammation and its resulting oxidative stress
  • Produces hydrogen peroxide which may help to kill cancer cells by forming the hydroxyl radical in cancer cells because they lack catalase
  • May help to neutralize certain cancer producing substances

There is a plethora of research beyond the early studies done by Pauling and Cameron.  For example, Drs. Murata and Morishige of Saga University in Japan showed that cancer patients given 5–30g of vitamin C lived six times longer than those on 4g or less, while those suffering from cancer of the uterus lived 15 times longer on vitamin C therapy. This was also confirmed by the late Dr Abram Hoffer in Canada, who found that patients on high doses of vitamin C survived, on average, ten times longer.

Treatment with high-dose vitamin C has been found to slow the growth and spread of prostate, breast, pancreatic, liver, colon, malignant mesothelioma, neuroblastoma, and other types of cancers.

Oral Vitamin C is better Than Intravenous Vitamin C

However through the work of Hickey, and others, we have learned that not only can oral intake be as effective asintravenousous C, it can actually be even more effective. Hickey maintains that since you can take oral vitamin C throughout the day as well as daily, the treatment is more effective.

He says that “the ‘vitamin C as chemotherapy’ model used for IVC assumes delivery of a relatively short, high burst of ascorbate. However, this does not apply to oral doses, which can be used to produce long term, sustained plasma levels.”  His findings show a large increase in cancer toxicity when the experimental exposure time was increased from 1 hour to 24 hours. He also found that alpha alpha-lipoic acid (R-ALA), copper, selenium, and other redox (oxygen –reducing) active supplements greatly increase the selective cytotoxicity of ascorbate.”

You may find the full article informative: Vitamin C and Cancer: Is There a Use for Oral C

The trick to being able to consume high levels of oral C without the typical bowel intolerance is to use Liposomal C or  Sodium Ascorbate. My two favorite brands of liposomal C are Mercola  and  Lypo-Spheric .  You can also make it at home.  One trip to google will provide DIY methods.

The Role of Sodium Ascorbate  

While liposomal C has been used for many years, new research has found that another form of vitamin C, sodium Ascorbate, is highly effective as  is also more affordable.

Please view this extremely informative video by  Dr Suzanne Humphries.  You will learn the safety and health benefits of  high dose vitamin C. She includes considerable information as to why sodium ascorbate can be helpful in your protocol.


How to Use HDVC

It is important to work with a professional before beginning this treatment.

  • A  G6PD test is recommended before any IVC infusions are given. Patients with a rare inherited disorder called G-6-PD deficiency should not be given high doses of vitamin C, due to the risk of hemolysis (a condition in which red blood cells are destroyed). Patients with a history of kidney disorders should not be treated with HDVC unless at the advice of a qualified physician (and supplementation with B6 as well as magnesium).
  • It is best to start slowly. Practitioners typically start a patient with 10 or 20 grams, increasing over a period of time to 50 grams. In previous years the doses went as high as 100 grams, but more recent research indicates this is not necessary. For oral C, you may want to start out with small doses, starting at 1-2 grams, three times a day and build up to your optimal dose which could be anywhere from 4-20 grams.
  • The use of ascorbic acid urine strips is recommended to find the right dose you’re your individual needs.
  • Consider supportive supplements such as alpha alpha-lipoic acid (R-ALA) and selenium.
  • You may feel ‘wiped out’, foggy, or shaky when you first begin this treatment. Plan accordingly. If using IVC, be sure you have someone to escort you home. If starting at home, plan to take a restorative nap. Consuming calcium/magnesium rick foods during this therapy can help alleviate such symptoms.
  • Do not use IV Glutathione the same day as HDVC as they will cancel each other out (antioxidant and proxidant).
  • Never begin any new therapy without the advice of a qualified physician

For more information and resources:

https://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-Cancer-Is-There-A-Use-For-Oral-Vitamin-C-28.1.pdf  Steve Hickey, PhD and Hilary Roberts, PhD










You may also want to visit the website of the Vitamin C Foundation at: http://vitamincfoundation.org/alerts.php

~~If you don’t know your options, you don’t have any~~
Elyn Jacobs is a breast cancer survivor and holistic cancer strategist who helps people make better, healthier, non-toxic choices. She emphasizes the critical nature of addressing the root cause of cancer and not just its presenting symptoms (such as the tumor). Elyn specializes in understanding the role of estrogen in breast cancer and debunks the myths associated. She is a Contributing Editor for The Truth About Cancer and was creator and host of the Survive and Live Well Radio Show on the Cancer Support Network. Elyn is on the Medical Advisory Board for BeatCancer.Org and is on the Advisory Board to the Radical Remission Project. Elyn was the former Executive Director of the Emerald Heart Cancer Foundation. Contact Elyn via her website. Elyn offers consults via Skype, phone or in person.

Follow Elyn on Facebook

Follow Elyn on Linkedin